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Diabetes, Vol 39, Issue 7 855-857, Copyright © 1990 by American Diabetes Association

ARTICLES

HLA-DP variation as additional risk factor in IDDM

S Easteal, MR Kohonen-Corish, P Zimmet and SW Serjeantson
Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Canberra.

A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P less than 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4.
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Copyright © 1990 by the American Diabetes Association.