Diabetes, Vol 40, Issue 1 134-140, Copyright © 1991 by American Diabetes Association

ARTICLES

Progressive deterioration of endocrine function after intraportal but not kidney subcapsular rat islet transplantation

WF Hiller, J Klempnauer, R Luck and B Steiniger
Clinic for Abdominal and Transplantation Surgery, Medical School, Hannover, Germany.

In inbred streptozocin-induced diabetic rats, the long-term function of different endocrine pancreatic isografts was compared. Isolated islets transplanted into the portal vein showed a progressive deterioration of function over time. In contrast, islets under the kidney capsule sustained a constant long-term function controlling all clinical signs of diabetes. Recipients of kidney subcapsular islets displayed normal growth rate, peripheral serum glucose and insulin levels, and metabolic parameters. However, their functional reserve was markedly reduced as revealed by diminished glucose tolerance and reduced insulin-secreting capacity after an intravenous glucose challenge. Vascularized whole-organ pancreatic grafts with portal venous drainage led to complete normalization of all parameters determined in this study. This study showed that the long-term function of islets transplanted under the kidney capsule is superior compared with islets transplanted into the portal vein.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. R. Rickels, M. Kamoun, J. Kearns, J. F. Markmann, and A. Naji Evidence for Allograft Rejection in an Islet Transplant Recipient and Effect on {beta}-Cell Secretory Capacity J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2410 - 2414. [Abstract] [Full Text] [PDF]

				J. Lau, G. Mattsson, C. Carlsson, D. Nyqvist, M. Kohler, P.-O. Berggren, L. Jansson, and P.-O. Carlsson Implantation Site-Dependent Dysfunction of Transplanted Pancreatic Islets Diabetes, June 1, 2007; 56(6): 1544 - 1550. [Abstract] [Full Text] [PDF]

				M. Bogdani, K. Suenens, T. Bock, M. Pipeleers-Marichal, P. In't Veld, and D. Pipeleers Growth and Functional Maturation of {beta}-Cells in Implants of Endocrine Cells Purified From Prenatal Porcine Pancreas Diabetes, December 1, 2005; 54(12): 3387 - 3394. [Abstract] [Full Text] [PDF]

				G. Mattsson, L. Jansson, A. Nordin, A. Andersson, and P.-O. Carlsson Evidence of Functional Impairment of Syngeneically Transplanted Mouse Pancreatic Islets Retrieved from the Liver Diabetes, April 1, 2004; 53(4): 948 - 954. [Abstract] [Full Text] [PDF]

				P.-O. Carlsson, F. Palm, A. Andersson, and P. Liss Markedly Decreased Oxygen Tension in Transplanted Rat Pancreatic Islets Irrespective of the Implantation Site Diabetes, March 1, 2001; 50(3): 489 - 495. [Abstract] [Full Text]