Diabetes, Vol 40, Issue 1 141-149, Copyright © 1991 by American Diabetes Association

ARTICLES

Differential effects of prednisone and growth hormone on fuel metabolism and insulin antagonism in humans

FF Horber, HM Marsh and MW Haymond
Department of Pediatrics, Mayo Clinic, Rochester, Minnesota.

Human growth hormone (hGH) and prednisone cause insulin resistance and glucose intolerance. However, it is unknown whether hGH and prednisone antagonize insulin action on protein, fat, and carbohydrate metabolism by a common or independent mechanism. Therefore, protein, fat, and carbohydrate metabolism was assessed simultaneously in four groups of eight subjects each after 7 days of placebo, recombinant DNA hGH (rhGH; 0.1 mg.kg-1.day-1), prednisone (0.8 mg.kg-1.day-1), or rhGH and prednisone administration after an 18-h fast and during gut infusion of glucose and amino acids (fed state). Fasting plasma glucose concentrations were similar during placebo and rhGH but elevated (P less than 0.001) during combined treatment, whereas plasma insulin concentrations were higher (237 +/- 57 pmol/ml, P less than 0.001) during combined than during placebo, rhGH, or prednisone treatment (34, 52, and 91 pM, respectively). In the fed state, plasma glucose concentrations were elevated only during combined treatment (11.3 +/- 2.1 mM, P less than 0.001). Plasma insulin concentrations were elevated during therapy with prednisone alone and rhGH alone (667 +/- 72 and 564 +/- 65 pmol/ml, respectively, P less than 0.001) compared with placebo (226 +/- 44 pmol/ml) but lower than with the combined rhGH and prednisone treatment (1249 +/- 54 pmol/ml, P less than 0.01). Protein oxidation [( 14C]leucine) increased (P less than 0.001) with prednisone therapy, decreased (P less than 0.001) with rhGH treatment, and was normal during the combined treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				H. Liu, D. M. Bravata, I. Olkin, A. Friedlander, V. Liu, B. Roberts, E. Bendavid, O. Saynina, S. R. Salpeter, A. M. Garber, et al. Systematic Review: The Effects of Growth Hormone on Athletic Performance Ann Intern Med, May 20, 2008; 148(10): 747 - 758. [Abstract] [Full Text] [PDF]

				D. Simon, A.-M. Prieur, P. Quartier, J. Charles Ruiz, and P. Czernichow Early Recombinant Human Growth Hormone Treatment in Glucocorticoid-Treated Children with Juvenile Idiopathic Arthritis: A 3-Year Randomized Study J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2567 - 2573. [Abstract] [Full Text] [PDF]

				M. G. Burt, J. Gibney, and K. K. Y. Ho Protein metabolism in glucocorticoid excess: study in Cushing's syndrome and the effect of treatment Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1426 - E1432. [Abstract] [Full Text] [PDF]

				N. Hiscock, C. P. Fischer, M. Sacchetti, G. van Hall, M. A. Febbraio, and B. K. Pedersen Recombinant human interleukin-6 infusion during low-intensity exercise does not enhance whole body lipolysis or fat oxidation in humans Am J Physiol Endocrinol Metab, July 1, 2005; 289(1): E2 - E7. [Abstract] [Full Text] [PDF]

				E. W. Petersen, A. L. Carey, M. Sacchetti, G. R. Steinberg, S. L. Macaulay, M. A. Febbraio, and B. K. Pedersen Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro Am J Physiol Endocrinol Metab, January 1, 2005; 288(1): E155 - E162. [Abstract] [Full Text] [PDF]

				D. Darmaun, V. Hayes, D. Schaeffer, S. Welch, and N. Mauras Effects of Glutamine and Recombinant Human Growth Hormone on Protein Metabolism in Prepubertal Children with Cystic Fibrosis J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1146 - 1152. [Abstract] [Full Text] [PDF]

				G. van Hall, A. Steensberg, M. Sacchetti, C. Fischer, C. Keller, P. Schjerling, N. Hiscock, K. Moller, B. Saltin, M. A. Febbraio, et al. Interleukin-6 Stimulates Lipolysis and Fat Oxidation in Humans J. Clin. Endocrinol. Metab., July 1, 2003; 88(7): 3005 - 3010. [Abstract] [Full Text] [PDF]

				R. P. A. Rooman, G. Kuijpers, R. Gresnigt, R. Bloemen, J. G. Koster, and S. C. van Buul-Offers Dexamethasone Differentially Inhibits Thyroxine- or Growth Hormone-Induced Body and Organ Growth of Snell Dwarf Mice Endocrinology, June 1, 2003; 144(6): 2553 - 2558. [Abstract] [Full Text] [PDF]

				J. A. Bush, D. G. Burrin, A. Suryawan, P. M. J. O'Connor, H. V. Nguyen, P. J. Reeds, N. C. Steele, J. B. Van Goudoever, and T. A. Davis Somatotropin-induced protein anabolism in hindquarters and portal-drained viscera of growing pigs Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E302 - E312. [Abstract] [Full Text] [PDF]

				S. Tigas, A. Sunehag, and M. W. Haymond Metabolic Adaptation to Feeding and Fasting during Lactation in Humans J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 302 - 307. [Abstract] [Full Text] [PDF]

				J. J. Reilly, M. Brougham, C. Montgomery, F. Richardson, A. Kelly, and B. E. S. Gibson Effect of Glucocorticoid Therapy on Energy Intake in Children Treated for Acute Lymphoblastic Leukemia J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3742 - 3745. [Abstract] [Full Text] [PDF]

				W. Long, L. Wei, and E. J. Barrett Dexamethasone inhibits the stimulation of muscle protein synthesis and PHAS-I and p70 S6-kinase phosphorylation Am J Physiol Endocrinol Metab, April 1, 2001; 280(4): E570 - E575. [Abstract] [Full Text] [PDF]

				R. C. Vann, H. V. Nguyen, P. J. Reeds, N. C. Steele, D. R. Deaver, and T. A. Davis Somatotropin increases protein balance independent of insulin's effects on protein metabolism in growing pigs Am J Physiol Endocrinol Metab, July 1, 2000; 279(1): E1 - E10. [Abstract] [Full Text] [PDF]

				R. C. Vann, H. V. Nguyen, P. J. Reeds, D. G. Burrin, M. L. Fiorotto, N. C. Steele, D. R. Deaver, and T. A. Davis Somatotropin increases protein balance by lowering body protein degradation in fed, growing pigs Am J Physiol Endocrinol Metab, March 1, 2000; 278(3): E477 - E483. [Abstract] [Full Text] [PDF]

				M. Ottosson, P. Lönnroth, P. Björntorp, and S. Edén Effects of Cortisol and Growth Hormone on Lipolysis in Human Adipose Tissue J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 799 - 803. [Abstract] [Full Text]

				B. Schneeweiss, H. Lochs, C. Zauner, M. Fischer, J. Wyatt, T. Maier-Dobersberger, and B. Schneider Energy and Substrate Metabolism in Patients with Active Crohn's Disease J. Nutr., April 1, 1999; 129(4): 844 - 848. [Abstract] [Full Text]

				P. Schneiter and L. Tappy Kinetics of dexamethasone-induced alterations of glucose metabolism in healthy humans Am J Physiol Endocrinol Metab, November 1, 1998; 275(5): E806 - E813. [Abstract] [Full Text] [PDF]

				K. Berneis, R. Ninnis, J. Girard, B. M. Frey, and U. Keller Effects of Insulin-Like Growth Factor I Combined with Growth Hormone on Glucocorticoid-Induced Whole-Body Protein Catabolism in Man J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2528 - 2534. [Abstract] [Full Text] [PDF]