Diabetes, Vol 40, Issue 5 598-604, Copyright © 1991 by American Diabetes Association

ARTICLES

Endocrine-metabolic function in remission-phase IDDM during administration of cyclosporine

J Dupre, MR Jenner, JL Mahon, C Purdon, NW Rodger and CR Stiller
University of Western Ontario, University Hospital, London, Canada.

We have studied the endocrine-metabolic status of patients in non-insulin-receiving (NIR) remission of insulin-dependent diabetes mellitus (IDDM) within 6-60 mo of diagnosis during administration of cyclosporine, in comparison with nondiabetic subjects. IDDM patients in NIR remission were recognized when target glycemic control (plasma glucose and mean capillary blood glucose levels less than 7.8 mM before meals) was maintained without administration of insulin for at least 2 wk. In so-called isoglycemic tests, 50 g glucose was administered orally, and the glycemic curve was simulated in a subsequent study by programmed intravenous infusion of glucose. Under these conditions, the subjects with diabetes exhibited obvious glucose intolerance: acute beta-cell responses to intravenous glucose were virtually absent but significant, although subnormal responses were present after oral glucose. The responses of plasma immunoreactive gastric inhibitory polypeptide to oral glucose were normal. After bolus intravenous injections of glucose, the patients with diabetes again exhibited glucose intolerance; acute responses of immunoreactive insulin (IRI) and C-peptide were present, although grossly obtunded. On intravenous infusion of arginine (30 g in 30 min), the patients with diabetes showed substantial but subnormal increases in plasma IRI and C-peptide. Intravenous infusion of arginine elicited increments of plasma immunoreactive glucagon (IRGI) in both groups, and this response was slightly exaggerated in the patients with diabetes. On ingestion of a standard mixed meal (Sustacal) delivering 600 cal, there was a modest but significantly greater increase in plasma glucose levels in the diabetic subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. Dupre, M. T. Behme, and T. J. McDonald Exendin-4 Normalized Postcibal Glycemic Excursions in Type 1 Diabetes J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3469 - 3473. [Abstract] [Full Text] [PDF]

				C. Greenbaum, K. Seidel, and C. Pihoker The Case for Intravenous Arginine Stimulation In Lieu of Mixed-Meal Tolerance Tests as Outcome Measure for Intervention Studies in Recent-Onset Type 1 Diabetes Diabetes Care, May 1, 2004; 27(5): 1202 - 1204. [Full Text] [PDF]

				C. J. Greenbaum, R. L. Prigeon, and D. A. D'Alessio Impaired {beta}-Cell Function, Incretin Effect, and Glucagon Suppression in Patients With Type 1 Diabetes Who Have Normal Fasting Glucose Diabetes, April 1, 2002; 51(4): 951 - 957. [Abstract] [Full Text] [PDF]

				A. Jain, G. Avendano, S. Dharamsey, A. Dasmahapatra, R. Agarwal, A. Reddi, and T. Regan Left Ventricular Diastolic Function in Hypertension and Role of Plasma Glucose and Insulin : Comparison With Diabetic Heart Circulation, April 1, 1996; 93(7): 1396 - 1402. [Abstract] [Full Text]