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Diabetes, Vol 41, Issue 4 401-407, Copyright © 1992 by American Diabetes Association

ARTICLES

Mapping diabetes-susceptibility genes. Lessons learned from search for DNA marker for maturity-onset diabetes of the young

NJ Cox, KS Xiang, SS Fajans and GI Bell
Department of Medicine, University of Chicago, Illinois 60637.

During our search for a marker for non-insulin-dependent diabetes mellitus (NIDDM) in a large multigenerational family with a form of NIDDM termed maturity-onset diabetes of the young (MODY), we learned a great deal that may serve to streamline the search for diabetes-susceptibility genes in other families. We describe here our experience and suggest strategies that may enhance the search for markers for other diabetes susceptibility genes with genetic linkage approaches.
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