Diabetes, Vol 41, Issue 8 1022-1027, Copyright © 1992 by American Diabetes Association

ARTICLES

Islet cell and thyrogastric antibodies in 633 consecutive 15- to 34-yr-old patients in the diabetes incidence study in Sweden

M Landin-Olsson, FA Karlsson, A Lernmark and G Sundkvist
Department of Medicine, University of Lund, Malmo General Hospital, Sweden.

The effect of age on ICA and thyrogastric antibodies at diagnosis of IDDM was evaluated in 633 consecutively diagnosed Swedish diabetic patients aged 15-34 yr and in 282 volunteers of the same age. ICAs were present in 61% (383 of 633) of the patients and in 2% (5 of 282) of control subjects. When the initial classification was considered, ICAs were detected in 69% (327 of 473) of patients with IDDM, 23% (19 of 83) of those with NIDDM, 50% (36 of 72) of those with unclassifiable diabetes, and 20% (1 of 5) of those with secondary diabetes. The frequency of ICA fell significantly (P less than 0.001) with age in IDDM patients from 77% (104/135) in those 15-19 yr old to 52% (50 of 96) in 30- to 34-yr-old IDDM patients. The low frequency of ICA in 30- to 34-yr-old IDDM patients was confined to men (42%, 28 of 66). The frequency of gastric (H+, K(+)-ATPase) antibodies was significantly (P less than 0.05) higher in IDDM patients (10%, 47 of 449) than in patients with NIDDM (3%, 3 of 80) and unclassifiable diabetes (4%, 3 of 72). In conclusion, the frequency of ICA at the diagnosis of IDDM in young adult subjects decreases with increasing age, particularly in men. The frequent finding of ICA in patients considered to have NIDDM or unclassifiable diabetes indicates that misclassification of diabetes is frequent in young adult patients recently diagnosed with diabetes.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				T. Tuomi Type 1 and Type 2 Diabetes: What Do They Have in Common? Diabetes, December 1, 2005; 54(suppl_2): S40 - S45. [Abstract] [Full Text] [PDF]

				G. Stenstrom, A. Gottsater, E. Bakhtadze, B. Berger, and G. Sundkvist Latent Autoimmune Diabetes in Adults: Definition, Prevalence, {beta}-Cell Function, and Treatment Diabetes, December 1, 2005; 54(suppl_2): S68 - S72. [Abstract] [Full Text] [PDF]

				M. Svensson, G. Sundkvist, H. J. Arnqvist, E. Bjork, G. Blohme, J. Bolinder, M. Henricsson, L. Nystrom, O. Torffvit, I. Waernbaum, et al. Signs of Nephropathy May Occur Early in Young Adults With Diabetes Despite Modern Diabetes Management: Results from the nationwide population-based Diabetes Incidence Study in Sweden (DISS) Diabetes Care, October 1, 2003; 26(10): 2903 - 2909. [Abstract] [Full Text] [PDF]

				A. Pundziute-Lycka, B. Urbonaite, R. Ostrauskas, R. Zalinkevicius, and G. G. Dahlquist Incidence of Type 1 Diabetes in Lithuanians Aged 0-39 Years Varies by the Urban-Rural Setting, and the Time Change Differs for Men and Women During 1991-2000 Diabetes Care, March 1, 2003; 26(3): 671 - 676. [Abstract] [Full Text] [PDF]

				M. Henricsson, L. Nystrom, G. Blohme, J. Ostman, C. Kullberg, M. Svensson, A. Scholin, H. J. Arnqvist, E. Bjork, J. Bolinder, et al. The Incidence of Retinopathy 10 Years After Diagnosis in Young Adult People With Diabetes: Results from the nationwide population-based Diabetes Incidence Study in Sweden (DISS) Diabetes Care, February 1, 2003; 26(2): 349 - 354. [Abstract] [Full Text] [PDF]

				J. Graham, W. A. Hagopian, I. Kockum, L. S. Li, C. B. Sanjeevi, R. M. Lowe, J. B. Schaefer, M. Zarghami, H. L. Day, M. Landin-Olsson, et al. Genetic Effects on Age-Dependent Onset and Islet Cell Autoantibody Markers in Type 1 Diabetes Diabetes, May 1, 2002; 51(5): 1346 - 1355. [Abstract] [Full Text] [PDF]

				A. L. Lethagen, U.-B. Ericsson, B. Hallengren, L. Groop, and T. Tuomi Glutamic Acid Decarboxylase Antibody Positivity Is Associated with an Impaired Insulin Response to Glucose and Arginine in Nondiabetic Patients with Autoimmune Thyroiditis J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1177 - 1183. [Abstract] [Full Text] [PDF]

				B. Littorin, G. Sundkvist, L. Nyström, A. Carlson, M. Landin-Olsson, J. Östman, H. J. Arnqvist, E. Björk, G. Blohmé, J. Bolinder, et al. Family Characteristics and Life Events Before the Onset of Autoimmune Type 1 Diabetes in Young Adults: A nationwide study Diabetes Care, June 1, 2001; 24(6): 1033 - 1037. [Abstract] [Full Text]

				B Wesche, E Jaeckel, C Trautwein, H Wedemeyer, A Falorni, H Frank, A von zur Muhlen, M-P Manns, and G Brabant Induction of autoantibodies to the adrenal cortex and pancreatic islet cells by interferon alpha therapy for chronic hepatitis C Gut, March 1, 2001; 48(3): 378 - 383. [Abstract] [Full Text] [PDF]

				H. Li, E. Lindholm, P. Almgren, A. Gustafsson, C. Forsblom, L. Groop, and T. Tuomi Possible Human Leukocyte Antigen-Mediated Genetic Interaction between Type 1 and Type 2 Diabetes J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 574 - 582. [Abstract] [Full Text]

				C. Törn, M. Landin-Olsson, A. Lernmark, J. P. Palmer, H. J. Arnqvist, G. Blohmé, F. Lithner, B. Littorin, L. Nyström, B. Scherstén, et al. Prognostic Factors for the Course of {beta} Cell Function in Autoimmune Diabetes J. Clin. Endocrinol. Metab., December 1, 2000; 85(12): 4619 - 4623. [Abstract] [Full Text]

				E. S. Husebye, G. Gebre-Medhin, T. Tuomi, J. Perheentupa, M. Landin-Olsson, J. Gustafsson, F. Rorsman, and O. Kampe Autoantibodies against Aromatic L-Amino Acid Decarboxylase in Autoimmune Polyendocrine Syndrome Type I J. Clin. Endocrinol. Metab., January 1, 1997; 82(1): 147 - 150. [Abstract] [Full Text] [PDF]