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Diabetes, Vol 41, Issue 8 946-951, Copyright © 1992 by American Diabetes Association

ARTICLES

Improvement of nerve conduction in diabetic neuropathy. A follow-up study 4 yr after combined pancreatic and renal transplantation

G Solders, G Tyden, A Persson and CG Groth
Department of Clinical Neurophysiology, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.

Eighteen patients with long-standing insulin-dependent (type 1) diabetes mellitus and polyneuropathy were studied after combined pancreatic and renal transplantation. Repeated tests were performed on peripheral nerve function (electroneurography) and on autonomic function (R-R test) 6 mo and 1, 2, and 4 yr after the transplantation. Eighteen diabetic patients with only a kidney graft served as controls. After initial improvement of nerve conduction in both groups, probably caused by the elimination of uremia, further improvement was seen only in the euglycemic pancreas-graft recipients. Improvement of autonomic (parasympathetic) function was slight after 48 mo and was similar in both groups.
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Copyright © 1992 by the American Diabetes Association.