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Diabetes, Vol 42, Issue 12 1715-1720, Copyright © 1993 by American Diabetes Association

ARTICLES

A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development

S Bonner-Weir, LA Baxter, GT Schuppin and FE Smith
Joslin Diabetes Center, Boston, MA 02215.

Substantial regeneration of both the endocrine and exocrine pancreas occurs after a 90% partial pancreatectomy in the young adult rat. We have reported previously that replication of preexisting islet and exocrine cells is enhanced 3- to 4-fold. Here, we report a second pathway of regeneration, that of proliferation and differentiation of precursor cells in the ductal epithelium. As shown with in vivo pulse labeling using 5-bromo-2'-deoxyuridine, an expansion of the ductal epithelium occurs. Proliferation is seen first in the common pancreatic duct and sequentially in smaller ducts of the ductal tree as focal areas of proliferation small ductules form. By 60 h after pancreatectomy, only these focal areas show heavy 5-bromo-2'-deoxyuridine staining. These proliferating ductules comprise 12.8% of the pancreatic volume at 3 days after pancreatectomy but are uncommon at 7 days after pancreatectomy. Coincident with the appearance and disappearance of these regions was a 3.5-fold increased growth of the pancreatic remnant compared with its equivalent of sham animals. These small ductules differentiate into new pancreatic islets and exocrine tissue, forming new lobules of pancreas that are indistinguishable from the preexisting ones. This second pathway of rapid regeneration recapitulates embryonic development in its pattern of ductal proliferation and subsequent differentiation. Furthermore, these studies provide evidence of the presence of precursor/stem cells in the adult pancreas.
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Home page
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Diabetes, February 1, 2003; 52(2): 365 - 371.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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Home page
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Neogenesis of {beta}-Cells in Adult BETA2/NeuroD-Deficient Mice
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Home page
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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Diabetes, May 1, 2001; 50(5): 962 - 971.
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Home page
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Diabetes, April 1, 2001; 50(4): 785 - 796.
[Abstract] [Full Text]

Home page
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Diabetes, March 1, 2001; 50(3): 521 - 533.
[Abstract] [Full Text]

Home page
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Impaired {beta}-cell regeneration in perinatally malnourished rats: a study with STZ
FASEB J, December 1, 2000; 14(15): 2611 - 2617.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. M. Davalli, P. Maffi, C. Socci, F. Sanvito, M. Freschi, F. Bertuzzi, L. Falqui, V. Di Carlo, G. Pozza, and A. Secchi
Insights from a Successful Case of Intrahepatic Islet Transplantation into a Type 1 Diabetic Patient
J. Clin. Endocrinol. Metab., October 1, 2000; 85(10): 3847 - 3852.
[Abstract] [Full Text]

Home page
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S. Bonner-Weir, M. Taneja, G. C. Weir, K. Tatarkiewicz, K.-H. Song, A. Sharma, and J. J. O'Neil
In vitro cultivation of human islets from expanded ductal tissue
PNAS, July 5, 2000; 97(14): 7999 - 8004.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
P. Jacquemin, S. M. Durviaux, J. Jensen, C. Godfraind, G. Gradwohl, F. Guillemot, O. D. Madsen, P. Carmeliet, M. Dewerchin, D. Collen, et al.
Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3
Mol. Cell. Biol., June 15, 2000; 20(12): 4445 - 4454.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
S. Bonner-Weir
Perspective: Postnatal Pancreatic {beta} Cell Growth
Endocrinology, June 1, 2000; 141(6): 1926 - 1929.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. T. Finegood, G. C. Weir, and S. Bonner-Weir
Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats
Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E822 - E827.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. L. Jetton, J. M. Moates, J. Lindner, C. V. E. Wright, and M. A. Magnuson
Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells
PNAS, July 21, 1998; 95(15): 8654 - 8659.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. J. Gross, L. Weiss, I. Reibstein, J. van den Brand, H. Okamoto, A. Clark, and S. Slavin
Amelioration of Diabetes in Nonobese Diabetic Mice with Advanced Disease by Linomide-Induced Immunoregulation Combined with Reg Protein Treatment
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