Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wanke, T.
Right arrow Articles by Irsigler, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wanke, T.
Right arrow Articles by Irsigler, K.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 42, Issue 2 282-287, Copyright © 1993 by American Diabetes Association

ARTICLES

No effect of naloxone on ventilatory response to progressive hypercapnia in IDDM patients

T Wanke, H Abrahamian, H Lahrmann, D Formanek, M Merkle, M Auinger, H Zwick and K Irsigler
Pulmonary Department, Lainz Hospital, Vienna, Austria.

The ventilatory response to hyperoxic progressive hypercapnia was examined by comparing 3 test groups: 7 diabetic patients with AN, 8 diabetic patients without AN, and 8 normal control subjects. In each group, a significant linear correlation was found between PaCO2 and VE. The slopes of the regression curves relating PaCO2 to VE were significantly steeper in the healthy control subjects and diabetic patients without AN than in those with AN (P < 0.01). We conclude that the ventilatory response to progressive hypercapnia is reduced in diabetic patients with AN. By analyzing the power spectrum and the amplitude behavior of the diaphragmatic EMG (calculated from the fc and RMS, respectively), we could exclude a disturbance of neural descending pathways and respiratory muscle dysfunction as possible causal mechanisms for the impaired ventilatory response to increasing CO2. By using lung function analysis, causal factors such as alterations in respiratory system mechanics also could be excluded. As diabetes is known to affect the endogenous opioid system, which, in turn, affects the ventilatory response to CO2, naloxone, as a specific opioid antagonist, was administered in all 3 test groups. Naloxone produced a significant increase of ventilatory response to hypercapnia in the healthy control subjects (P < 0.01), but produced no effect in either of the diabetic groups.(ABSTRACT TRUNCATED AT 250 WORDS)
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. Tantucci, P. Bottini, C. Fiorani, M. L. Dottorini, F. Santeusanio, L. Provinciali, C. A. Sorbini, and G. Casucci
Cerebrovascular reactivity and hypercapnic respiratory drive in diabetic autonomic neuropathy
J Appl Physiol, March 1, 2001; 90(3): 889 - 896.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
M. Mancini, M. Filippelli, G. Seghieri, I. Iandelli, F. Innocenti, R. Duranti, and G. Scano
Respiratory Muscle Function and Hypoxic Ventilatory Control in Patients With Type I Diabetes
Chest, June 1, 1999; 115(6): 1553 - 1562.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1993 by the American Diabetes Association.