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Diabetes, Vol 42, Issue 5 773-777, Copyright © 1993 by American Diabetes Association

ARTICLES

Organization of the human GLUT2 (pancreatic beta-cell and hepatocyte) glucose transporter gene

J Takeda, T Kayano, H Fukomoto and GI Bell
Howard Hughes Medical Institute, Chicago, IL 60637.

The gene encoding the predominant facilitative glucose transporter expressed in pancreatic beta-cells and hepatocytes, termed GLUT2, has been cloned and characterized. The human GLUT2 gene is composed of 11 exons spanning approximately 30 kilobases. The sequence of the promoter region and all exons and adjacent intron regions has been determined and deposited in the GenBank database. Two highly polymorphic simple tandem repeat DNA polymorphisms useful for linkage studies were localized in introns 1 and 4a. In addition, a 168-base pair insertion/deletion polymorphism was identified in intron 3. The characterization of the human GLUT2 gene will facilitate studies of its role in the development of diabetes mellitus.
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