Diabetes, Vol 42, Issue 7 1094-1098, Copyright © 1993 by American Diabetes Association

ARTICLES

Superantigen-like effects and incidence of diabetes in NOD mice

M McDuffie and A Ostrowska
Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908.

The population of T-cells that develops in any individual can be divided into families based on sequence differences in the beta-chain variable region of the T-cell receptor heterodimer. Major histocompatibility complex products and endogenous retroviral gene products have both been shown to exert powerful influences on the frequency distribution of T-cell receptor beta-chain variable region families in the mouse. In most mouse strains, these repertoire modifiers appear to be fully functional early in mouse development and shape a repertoire of antigen specificities that remains essentially unchanged from the first weeks of life until old age. In NOD mice, an inbred mouse model of type I diabetes, puberty in males coincides with a beta-chain variable region-specific T-cell expansion that mimics the results of exposure to exogenous superantigens in immunologically mature animals. The subsequent behavior of this subset indicates that it may play a role in the relative protection of male NOD mice from complete pancreatic beta-cell destruction and overt diabetes.
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