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Diabetes, Vol 43, Issue 1 47-52, Copyright © 1994 by American Diabetes Association

ARTICLES

Peculiar T-cell signaling does not preclude positive selection in the diabetes-prone BB rat

D Bellgrau, JM Redd and KS Sellins
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver.

Various studies have provided evidence that peripheral T-cells from the diabetes-prone BB-DP rat are abnormal in function and cell surface phenotype. These characteristics have often been interpreted as indicators of immaturity and/or short life span. In this study, we describe a CD4-dependent signaling abnormality in BB-DP peripheral T-cells. In spite of the fact that CD4 plays a critical role in thymocyte development, the abnormal signaling does not appear to influence thymocyte development at the stage when the T-cell receptor is rearranged and the recombinase enzymes RAG-1 and RAG-2 transcripts are downregulated. Therefore, if a maturation defect leading to the seeding of the periphery with immature T-cells occurs in the BB-DP rat, it does not preclude the initial selection of the self major histocompatibility complex-restricted T-cell repertoire.
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Copyright © 1994 by the American Diabetes Association.