Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cohen, W. R.
Right arrow Articles by Deutsch, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cohen, W. R.
Right arrow Articles by Deutsch, J.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 43, Issue 5 645-648, Copyright © 1994 by American Diabetes Association

ARTICLES

Hyperglycemia suppresses the adrenal medullary response to hypoxemia

WR Cohen and J Deutsch
Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York 10461.

An in vivo microdialysis technique was used to study adrenal medullary function in 6 euglycemic and 6 hyperglycemic anesthetized Sprague-Dawley rats exposed to hypoxia. After stabilization of an adrenal dialysis probe, dialyzable adrenal epinephrine and norepinephrine were measured in response to 15 min of 7.8% oxygen breathing in both groups. In euglycemic rats, hypoxia increased epinephrine and norepinephrine by 650 and 320% above baseline, respectively. During hyperglycemia, (mean plasma glucose level 30.0 mM) epinephrine and norepinephrine rose only 119 and 104%, respectively. The catecholamine increase in the hyperglycemic rats was significantly attenuated in comparison to euglycemic controls (epinephrine, P = 0.0232; norepinephrine, P = 0.0079). These data demonstrate that acute hyperglycemia has the capacity to suppress the normal adrenal medullary response to hypoxemia.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1994 by the American Diabetes Association.