Diabetes, Vol 44, Issue 10 1243-1247, Copyright © 1995 by American Diabetes Association

ARTICLES

Linkage analyses of the MODY3 locus on chromosome 12q with late-onset NIDDM

S Lesage, EH Hani, A Philippi, M Vaxillaire, J Hager, P Passa, F Demenais, P Froguel and N Vionnet
Centre National de la Recherche Scientifique EP10, CEPH, Paris, France.

Non-insulin-dependent diabetes mellitus (NIDDM) is a clinically and genetically heterogeneous disorder. Maturity-onset diabetes of the young (MODY), an autosomal dominant form of NIDDM, has been used as a model for genetic studies of NIDDM. We recently reported linkage between markers on chromosome 12q and diabetes in 25% of our French MODY families. To evaluate if this gene is also implicated in late-onset NIDDM, we performed linkage studies between two markers of the MODY region and diabetes in 172 families with late-onset NIDDM. Both parametric and nonparametric methods were used in a total of 600 affected sib-pairs. Linkage was rejected in this population by all methods, implying that the MODY gene on chromosome 12q is not a major gene for late-onset NIDDM in this population. However, we cannot exclude a modifying role in a polygenic disorder or an important role in some families.
CiteULike    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				T. M. Frayling, M. I. McCarthy, M. Walker, J. C. Levy, S. O’Rahilly, G. A. Hitman, P. V. Subba Rao, A. J. Bennett, E. C. Jones, S. Menzel, et al. No Evidence for Linkage at Candidate Type 2 Diabetes Susceptibility Loci on Chromosomes 12 and 20 in United Kingdom Caucasians J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 853 - 857. [Abstract] [Full Text]

				S. C. Elbein, K. Teng, P. Yount, and E. Scroggin Linkage and Molecular Scanning Analyses of MODY3/Hepatocyte Nuclear Factor-1{alpha} Gene in Typical Familial Type 2 Diabetes: Evidence for Novel Mutations in Exons 8 and 10 J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 2059 - 2065. [Abstract] [Full Text]