Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Menzel, S.
Right arrow Articles by et, al.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Menzel, S.
Right arrow Articles by et, al.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 44, Issue 12 1408-1413, Copyright © 1995 by American Diabetes Association

ARTICLES

Localization of MODY3 to a 5-cM region of human chromosome 12

S Menzel, K Yamagata, JB Trabb, J Nerup, MA Permutt, SS Fajans, R Menzel, N Iwasaki, Y Omori, NJ Cox and al. et
Howard Hughes Medical Institute, University of Chicago, Illinois, USA.

Maturity-onset diabetes of the young (MODY) is a heterogeneous disorder that appears to be characterized by a primary defect in insulin secretion. Mutations in an unknown locus (MODY1) on chromosome 20 and the glucokinase gene (MODY2) on chromosome 7 can cause this form of non-insulin-dependent diabetes. Recent genetic studies have identified a third locus on chromosome 12 (MODY3) that is linked to MODY in a group of French families. We have identified three families from Denmark, Germany, and the U.S. (Michigan) showing evidence of linkage with MODY3 and a family from Japan showing suggestive evidence. Analysis of key recombinants in these families localized MODY3 to a 5-cM interval between the markers D12S86 and D12S807/D12S820.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
L. Pérusse, T. Rice, Y. C. Chagnon, J.-P. Després, S. Lemieux, S. Roy, M. Lacaille, M.-A. Ho-Kim, M. Chagnon, M. A. Province, et al.
A Genome-Wide Scan for Abdominal Fat Assessed by Computed Tomography in the Quebec Family Study
Diabetes, March 1, 2001; 50(3): 614 - 621.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. M. Frayling, M. I. McCarthy, M. Walker, J. C. Levy, S. O’Rahilly, G. A. Hitman, P. V. Subba Rao, A. J. Bennett, E. C. Jones, S. Menzel, et al.
No Evidence for Linkage at Candidate Type 2 Diabetes Susceptibility Loci on Chromosomes 12 and 20 in United Kingdom Caucasians
J. Clin. Endocrinol. Metab., February 1, 2000; 85(2): 853 - 857.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. C. Elbein, K. Teng, P. Yount, and E. Scroggin
Linkage and Molecular Scanning Analyses of MODY3/Hepatocyte Nuclear Factor-1{alpha} Gene in Typical Familial Type 2 Diabetes: Evidence for Novel Mutations in Exons 8 and 10
J. Clin. Endocrinol. Metab., June 1, 1998; 83(6): 2059 - 2065.
[Abstract] [Full Text]

Home page
 The Diabetes EducatorHome page
E. A. Cabanas
Maturity-Onset Diabetes of the Young: Recent Findings Indicate Insulin Resistance/Obesity Are Not Factors
The Diabetes Educator, January 1, 1998; 24(4): 477 - 480.
[PDF]

Home page
 NEJMHome page
K. S. Polonsky, J. Sturis, and G. I. Bell
Non-Insulin-Dependent Diabetes Mellitus -- A Genetically Programmed Failure of the Beta Cell to Compensate for Insulin Resistance
N. Engl. J. Med., March 21, 1996; 334(12): 777 - 783.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1995 by the American Diabetes Association.