Diabetes, Vol 44, Issue 5 555-560, Copyright © 1995 by American Diabetes Association

ARTICLES

Skeletal muscle GLUT4 protein concentration and aging in humans

JA Houmard, MD Weidner, PL Dolan, N Leggett-Frazier, KE Gavigan, MS Hickey, GL Tyndall, D Zheng, A Alshami and GL Dohm
Human Performance Laboratory, School of Health and Human Performance, East Carolina University, Greenville, NC 27858, USA.

The insulin resistance of aging has been attributed to a postreceptor defect in skeletal muscle. The present study examined whether a reduction in the concentration of the insulin-stimulated glucose transporter (GLUT4) in skeletal muscle was associated with advancing age in men (n = 55) and women (n = 29). Insulin sensitivity (minimal model) was negatively associated (P < 0.001) with age (range, 18-80 years) in men (r = -0.44) and women (r = -0.58). GLUT4 protein concentration in the vastus lateralis was also negatively associated (P < 0.05) with age (men, r = -0.28; women, r = -0.51). There was no relation (P > 0.15) between GLUT4 content in the gastrocnemius and age. GLUT4 concentration in the vastus lateralis was positively associated (P < 0.01) with insulin sensitivity in both sexes (r = 0.42); this relationship persisted in the men after adjusting for overall adiposity, regional adiposity, and cardiorespiratory fitness. These findings suggest that a decrement in GLUT4 protein concentration in skeletal muscle may at least partially contribute to the insulin resistance of aging in humans.
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