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Diabetes, Vol 45, Issue 12 1761-1765, Copyright © 1996 by American Diabetes Association

ARTICLES

Tissue-specific self-peptides bound by major histocompatibility complex class I molecules of a human pancreatic beta-cell line

KP Papadopoulos, AI Colovai, A Maffei, D Jaraquemada, N Suciu-Foca and PE Harris
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

The process of beta-cell destruction in IDDM is mediated, in part, by CD8+ T-cells. Structural characterization of HLA-I-bound self-peptides presented by the human beta-cell line HP-62 was performed to identify possible tissue-specific autoantigens in the context of CD8+ T-cell/HLA-I interactions. The sequences of the beta-cell line HLA-I-bound peptides were compared with sequence databases. Six of the obtained sequences showed homology to known precursor proteins, three of which--GLUT2 receptor, phosphatidylinositol-glycan-specific phospholipase D, and 5-hydroxytryptamine-1F receptor--have a limited, tissue-specific expression. These HLA-bound self-peptides may be part of a pool of autoantigens recognized by beta-cell reactive cytotoxic T-cells.
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H. D. Hickman, A. D. Luis, R. Buchli, S. R. Few, M. Sathiamurthy, R. S. VanGundy, C. F. Giberson, and W. H. Hildebrand
Toward a Definition of Self: Proteomic Evaluation of the Class I Peptide Repertoire
J. Immunol., March 1, 2004; 172(5): 2944 - 2952.
[Abstract] [Full Text] [PDF]


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Copyright © 1996 by the American Diabetes Association.