Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schnell, O.
Right arrow Articles by Standl, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schnell, O.
Right arrow Articles by Standl, E.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 45, Issue 6 801-805, Copyright © 1996 by American Diabetes Association

ARTICLES

Reduced myocardial 123I-metaiodobenzylguanidine uptake in newly diagnosed IDDM patients

O Schnell, D Muhr, M Weiss, S Dresel, M Haslbeck and E Standl
Diabetes Research Institute, Schwabing City Hospital, Munich, Germany.

123I-labeled metaiodobenzylguanidine (123I-MIBG) scintigraphy is a novel technique for the assessment of cardiac sympathetic dysinnervation. To evaluate defects of the cardiac autonomic nervous system at the onset of IDDM, this technique together with conventional electrocardiogram (ECG)-based cardiac reflex tests and measurement of the QT interval was applied to 22 newly diagnosed metabolically stabilized IDDM patients without myocardial perfusion abnormalities (99mTc-labeled methoxyisobutylisonitrile scintigraphy) and 9 matched control subjects. Seventeen diabetic patients (77%), but none of the control subjects, were observed to have a reduced global myocardial uptake of 123I-MIBG. In contrast, only two diabetic patients (9%) demonstrated an ECG-based cardiac autonomic neuropathy (two or more of five age-related cardiac reflex tests abnormal) (P < 0.001). In newly diagnosed IDDM patients, the uptake of 123I-MIBG was reduced more in the posterior myocardial region compared with the lateral and apical region (P < 0.01, P = 0.03). The septal myocardial region exhibited a smaller uptake than the lateral myocardial region (P = 0.02). The maximum/minimum 30:15 ratio correlated with the global, anterior, lateral, and septal myocardial uptake of 123I-MIBG (P < 0.05, P < 0.05, P < 0.01, P < 0.05). A correlation between global and regional myocardial 123I-MIBG uptake and HbA1c or QT interval was not observed. Newly diagnosed metabolically stabilized IDDM patients without myocardial perfusion defects show evidence of cardiac sympathetic dysinnervation, as indicated by a reduction of 123I-MIBG uptake, at a significant higher proportion than ECG-based cardiac autonomic neuropathy. Furthermore, they present with regional differences of myocardial 123I-MIBG uptake.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J Am Coll CardiolHome page
R. Pop-Busui, I. Kirkwood, H. Schmid, V. Marinescu, J. Schroeder, D. Larkin, E. Yamada, D. M. Raffel, and M. J. Stevens
Sympathetic dysfunction in type 1 diabetes: Association with impaired myocardial blood flow reserve and diastolic dysfunction
J. Am. Coll. Cardiol., December 21, 2004; 44(12): 2368 - 2374.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
Z. Y. Fang, J. B. Prins, and T. H. Marwick
Diabetic Cardiomyopathy: Evidence, Mechanisms, and Therapeutic Implications
Endocr. Rev., August 1, 2004; 25(4): 543 - 567.
[Abstract] [Full Text] [PDF]

Home page
 J. Nucl. Med. Technol.Home page
L. A. Scott and P. L. Kench
Cardiac Autonomic Neuropathy in the Diabetic Patient: Does 123I-MIBG Imaging Have a Role to Play in Early Diagnosis?
J. Nucl. Med. Technol., June 1, 2004; 32(2): 66 - 71.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. K. Hahn, D. Robertson, and R. D. Blakely
A Mutation in the Human Norepinephrine Transporter Gene (SLC6A2) Associated with Orthostatic Intolerance Disrupts Surface Expression of Mutant and Wild-Type Transporters
J. Neurosci., June 1, 2003; 23(11): 4470 - 4478.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
A. Druschky, M. J. Hilz, P. Hopp, G. Platsch, M. Radespiel-Troger, K. Druschky, T. Kuwert, H. Stefan, and B. Neundorfer
Interictal cardiac autonomic dysfunction in temporal lobe epilepsy demonstrated by [123I]metaiodobenzylguanidine-SPECT
Brain, December 1, 2001; 124(12): 2372 - 2382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. R. Russell III, D. Chyun, S. Song, R. S. Sherwin, W. V. Tamborlane, F. A. Lee, M. A. Pfeifer, F. Rife, F. J. T. Wackers, and L. H. Young
Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients
Am J Physiol Endocrinol Metab, November 1, 2001; 281(5): E1029 - E1036.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
N. Takahashi, M. Nakagawa, T. Saikawa, T. Ooie, K. Yufu, S. Shigematsu, M. Hara, H. Sakino, I. Katsuragi, T. Okeda, et al.
Effect of essential hypertension on cardiac autonomic function in type 2 diabetic patients
J. Am. Coll. Cardiol., July 1, 2001; 38(1): 232 - 237.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1996 by the American Diabetes Association.