Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Klein, S.
Right arrow Articles by Landt, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Klein, S.
Right arrow Articles by Landt, M.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 45, Issue 7 984-987, Copyright © 1996 by American Diabetes Association

ARTICLES

Adipose tissue leptin production and plasma leptin kinetics in humans

S Klein, SW Coppack, V Mohamed-Ali and M Landt
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri 63110-1093, USA. sklein@imgate.wustl.edu

Abdominal adipose tissue leptin production was determined in vivo by arteriovenous balance in 14 lean and obese men (mean BMI 27.0 +/- 1.9, range 21.4-45.2). Blood samples were taken simultaneously from an abdominal vein that drains subcutaneous adipose tissue and from a radial artery. Adipose tissue blood flow was measured by xenon washout. Abdominal vein leptin concentrations (mean 8.9 +/- 2.4 ng/ml, range 2.1-36.5 ng/ml) were consistently greater than arterial values (mean 6.6 +/- 1.9 ng/ml, range 1.7-28.2 ng/ml) (P < 0.001). The net rate of abdominal adipose tissue leptin production (mean 3.2 +/- 0.5 ng x 100 g(-1) x min(-1)) correlated directly with percentage body fat (rs = 0.59, P = 0.016). Estimated whole-body leptin production rate (797 +/- 283 ng x person(-1) x min(-1)) correlated directly with percent body fat (rs = 0.93, P < 0.0001) and with regional leptin production (rs = 0.81, P < 0.001). In contrast, the rate of leptin clearance from plasma (mean 1.50 +/- 0.23 ml x kg(-1) x min(-1)) and plasma leptin half-life (mean 24.9 +/- 4.4 min) was unrelated to adiposity (rs = 0.06, P = 0.30; rs = 0.16, P = 0.30, respectively). These results provide direct evidence that leptin is produced by adipose tissue in humans and that the rate of production is directly related to adiposity. A combination of greater leptin production per unit of body fat and increased production from expanded total body fat mass, rather than alterations in leptin clearance, account for the increase in plasma leptin concentrations observed in obese humans.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 ThoraxHome page
F M E Franssen, D E O'Donnell, G H Goossens, E E Blaak, and A M W J Schols
Obesity and the lung: 5 {middle dot} Obesity and COPD
Thorax, December 1, 2008; 63(12): 1110 - 1117.
[Abstract] [Full Text] [PDF]

Home page
 J DAIRY SCIHome page
L. F. P. Silva, B. E. Etchebarne, M. S. Weber Nielsen, J. S. Liesman, M. Kiupel, and M. J. VandeHaar
Intramammary Infusion of Leptin Decreases Proliferation of Mammary Epithelial Cells in Prepubertal Heifers
J Dairy Sci, August 1, 2008; 91(8): 3034 - 3044.
[Abstract] [Full Text] [PDF]

Home page
 J. Gerontol. A Biol. Sci. Med. Sci.Home page
D. L. Waters, C. R. Qualls, R. I. Dorin, J. D. Veldhuis, and R. N. Baumgartner
Altered Growth Hormone, Cortisol, and Leptin Secretion in Healthy Elderly Persons With Sarcopenia and Mixed Body Composition Phenotypes
J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2008; 63(5): 536 - 541.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
S. Karahuseyinoglu, C. Kocaefe, D. Balci, E. Erdemli, and A. Can
Functional Structure of Adipocytes Differentiated from Human Umbilical Cord Stroma-Derived Stem Cells
Stem Cells, March 1, 2008; 26(3): 682 - 691.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. R. Casey, K. O. Cantillo, and L. K. Brown
Sleep-Related Hypoventilation/Hypoxemic Syndromes
Chest, June 1, 2007; 131(6): 1936 - 1948.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
C. L. Adam, P. A. Findlay, and D. W. Miller
Blood-Brain Leptin Transport and Appetite and Reproductive Neuroendocrine Responses to Intracerebroventricular Leptin Injection in Sheep: Influence of Photoperiod
Endocrinology, October 1, 2006; 147(10): 4589 - 4598.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
P. F. Pilch and N. Bergenhem
Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes
Mol. Pharmacol., September 1, 2006; 70(3): 779 - 785.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
S. O Krechowec, M. Vickers, A. Gertler, and B. H Breier
Prenatal influences on leptin sensitivity and susceptibility to diet-induced obesity.
J. Endocrinol., May 1, 2006; 189(2): 355 - 363.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Misra, K. K. Miller, K. Kuo, K. Griffin, V. Stewart, E. Hunter, D. B. Herzog, and A. Klibanski
Secretory dynamics of leptin in adolescent girls with anorexia nervosa and healthy adolescents
Am J Physiol Endocrinol Metab, September 1, 2005; 289(3): E373 - E381.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
N. Eikelis and M. Esler
The neurobiology of human obesity
Exp Physiol, September 1, 2005; 90(5): 673 - 682.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. R. Berggren, M. W. Hulver, and J. A. Houmard
Fat as an endocrine organ: influence of exercise
J Appl Physiol, August 1, 2005; 99(2): 757 - 764.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Harte, P. McTernan, R. Chetty, S. Coppack, J. Katz, S. Smith, and S. Kumar
Insulin-Mediated Upregulation of the Renin Angiotensin System in Human Subcutaneous Adipocytes Is Reduced by Rosiglitazone
Circulation, April 19, 2005; 111(15): 1954 - 1961.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Alemzadeh and K. M. Tushaus
Modulation of Adipoinsular Axis in Prediabetic Zucker Diabetic Fatty Rats by Diazoxide
Endocrinology, December 1, 2004; 145(12): 5476 - 5484.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. E. Swain, R. L. Dunn, D. McConnell, J. Gonzalez-Martinez, and G. D. Smith
Direct Effects of Leptin on Mouse Reproductive Function: Regulation of Follicular, Oocyte, and Embryo Development
Biol Reprod, November 1, 2004; 71(5): 1446 - 1452.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Bluher and C. S. Mantzoros
The Role of Leptin in Regulating Neuroendocrine Function in Humans
J. Nutr., September 1, 2004; 134(9): 2469S - 2474S.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. L. Wong, A. M. DePaoli, J. H. Lee, and C. S. Mantzoros
Leptin Hormonal Kinetics in the Fed State: Effects of Adiposity, Age, and Gender on Endogenous Leptin Production and Clearance Rates
J. Clin. Endocrinol. Metab., June 1, 2004; 89(6): 2672 - 2677.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
N. Eikelis, G. Lambert, G. Wiesner, D. Kaye, M. Schlaich, M. Morris, J. Hastings, F. Socratous, and M. Esler
Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function
Am J Physiol Endocrinol Metab, May 1, 2004; 286(5): E744 - E752.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Hoffstedt, E. Arvidsson, E. Sjolin, K. Wahlen, and P. Arner
Adipose Tissue Adiponectin Production and Adiponectin Serum Concentration in Human Obesity and Insulin Resistance
J. Clin. Endocrinol. Metab., March 1, 2004; 89(3): 1391 - 1396.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. M. Morberg, I. Tetens, E. Black, S. Toubro, T. I. A. Soerensen, O. Pedersen, and A. Astrup
Leptin and Bone Mineral Density: A Cross-Sectional Study in Obese and Nonobese Men
J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5795 - 5800.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
W. I. Sivitz, S. M. Wayson, M. L. Bayless, L. F. Larson, C. Sinkey, R. S. Bar, and W. G. Haynes
Leptin and Body Fat in Type 2 Diabetes and Monodrug Therapy
J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1543 - 1553.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A. Singhal, I S. Farooqi, S. O'Rahilly, T. J Cole, M. Fewtrell, and A. Lucas
Early nutrition and leptin concentrations in later life
Am. J. Clinical Nutrition, June 1, 2002; 75(6): 993 - 999.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. S. Randeva, R. D. Murray, K. C. Lewandowski, C. J. O'Callaghan, R. Horn, P. O'Hare, G. Brabant, E. W. Hillhouse, and S. M. Shalet
Differential Effects of GH Replacement on the Components of the Leptin System in GH-Deficient Individuals
J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 798 - 804.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
M Fitzpatrick
Leptin and the obesity hypoventilation syndrome: a leap of faith?
Thorax, January 1, 2002; 57(1): 1 - 2.
[Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. M. Moran, T. P. Stein, and C. E. Wade
Hormonal Modulation of Food Intake in Response to Low Leptin Levels Induced by Hypergravity
Experimental Biology and Medicine, September 1, 2001; 226(8): 740 - 745.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Landt, J. F. Horowitz, S. W. Coppack, and S. Klein
Effect of Short-Term Fasting on Free and Bound Leptin Concentrations in Lean and Obese Women
J. Clin. Endocrinol. Metab., August 1, 2001; 86(8): 3768 - 3771.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. J. Fogteloo, A. E. Meinders, H. Pijl, A. A. Kroon, M. Frolich, and P. W. De Leeuw
Renal clearance of endogenous leptin in hypertensive humans with or without renal artery stenosis
Am J Physiol Endocrinol Metab, August 1, 2001; 281(2): E400 - E404.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Lepercq, J.-C. Challier, M. Guerre-Millo, M. Cauzac, H. Vidal, and S. Hauguel-de Mouzon
Prenatal Leptin Production: Evidence That Fetal Adipose Tissue Produces Leptin
J. Clin. Endocrinol. Metab., June 1, 2001; 86(6): 2409 - 2413.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. K. Fried, M. R. Ricci, C. D. Russell, and B. Laferrere
Regulation of Leptin Production in Humans
J. Nutr., December 1, 2000; 130 (12): 3127S - 3131S.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. Linnemann, A. Malek, R. Sager, W. F. Blum, H. Schneider, and C. Fusch
Leptin Production and Release in the Dually in VitroPerfused Human Placenta
J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 4298 - 4301.
[Abstract] [Full Text]

Home page
 J. Am. Soc. Nephrol.Home page
G. GARIBOTTO, A. BARRECA, A. SOFIA, R. RUSSO, F. FIORINI, G. CAPPELLI, F. CAVATORTA, A. CESARONE, R. FRANCESCHINI, P. SACCO, et al.
Effects of Growth Hormone on Leptin Metabolism and Energy Expenditure in Hemodialysis Patients with Protein-Calorie Malnutrition
J. Am. Soc. Nephrol., November 1, 2000; 11(11): 2106 - 2113.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. H. Pinkney, O. Boss, G. A. Bray, K. Bulmer, S. W. Coppack, and V. Mohamed-Ali
Physiological Relationships of Uncoupling Protein-2 Gene Expression in Human Adipose Tissue in Vivo
J. Clin. Endocrinol. Metab., June 1, 2000; 85(6): 2312 - 2317.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
P. S. Duggal, K. H. Van der Hoek, C. R. Milner, N. K. Ryan, D. T. Armstrong, D. A. Magoffin, and R. J. Norman
The in Vivo and in Vitro Effects of Exogenous Leptin on Ovulation in the Rat
Endocrinology, June 1, 2000; 141(6): 1971 - 1976.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
M. Landt, C. A. Parvin, and M. Wong
Leptin in Cerebrospinal Fluid from Children: Correlation with Plasma Leptin, Sexual Dimorphism, and Lack of Protein Binding
Clin. Chem., June 1, 2000; 46(6): 854 - 858.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
R. J. Richards, J. R. Porter, and F. Svec
Serum Leptin, Lipids, Free Fatty Acids, and Fat Pads in Long-Term Dehydroepiandrosterone-Treated Zucker Rats
Experimental Biology and Medicine, March 1, 2000; 223(3): 258 - 262.
[Abstract] [Full Text]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
F. Krempler, D. Breban, H. Oberkofler, H. Esterbauer, E. Hell, B. Paulweber, and W. Patsch
Leptin, Peroxisome Proliferator-Activated Receptor-{gamma}, and CCAAT/Enhancer Binding Protein-{alpha} mRNA Expression in Adipose Tissue of Humans and Their Relation to Cardiovascular Risk Factors
Arterioscler. Thromb. Vasc. Biol., February 1, 2000; 20(2): 443 - 449.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
V. Mohamed-Ali, S. Goodrick, K. Bulmer, J. M. P. Holly, J. S. Yudkin, and S. W. Coppack
Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo
Am J Physiol Endocrinol Metab, December 1, 1999; 277(6): E971 - E975.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. Fors, H. Matsuoka, I. Bosaeus, S. Rosberg, K. A. Wikland, and R. Bjarnason
Serum Leptin Levels Correlate with Growth Hormone Secretion and Body Fat in Children
J. Clin. Endocrinol. Metab., October 1, 1999; 84(10): 3586 - 3590.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Bryson, J. L. Phuyal, V. Swan, and I. D. Caterson
Leptin has acute effects on glucose and lipid metabolism in both lean and gold thioglucose-obese mice
Am J Physiol Endocrinol Metab, September 1, 1999; 277(3): E417 - E422.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
L. De Marinis, A. Mancini, D. Valle, A. Bianchi, D. Milardi, A. Proto, A. Lanzone, and R. Tacchino
Plasma Leptin Levels after Biliopancreatic Diversion: Dissociation with Body Mass Index
J. Clin. Endocrinol. Metab., July 1, 1999; 84(7): 2386 - 2389.
[Abstract] [Full Text]

Home page
 Hum ReprodHome page
T. Sir-Petermann, V. Piwonka, F. Perez, M. Maliqueo, S.E. Recabarren, and L. Wildt
Are circulating leptin and luteinizing hormone synchronized in patients with polycystic ovary syndrome?
Hum. Reprod., June 1, 1999; 14(6): 1435 - 1439.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. A. Pelleymounter, M. B. Baker, and M. McCaleb
Does estradiol mediate leptin's effects on adiposity and body weight?
Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E955 - E963.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
C. S. Mantzoros
The Role of Leptin in Human Obesity and Disease: A Review of Current Evidence
Ann Intern Med, April 20, 1999; 130(8): 671 - 680.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
E. Jequier and L. Tappy
Regulation of Body Weight in Humans
Physiol Rev, April 1, 1999; 79(2): 451 - 480.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. D Jensen, N. Moller, K Sreekumaran Nair, P. Eisenberg, M. Landt, and S. Klein
Regional leptin kinetics in humans
Am. J. Clinical Nutrition, January 1, 1999; 69(1): 18 - 21.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Vila, C. Adan, I. Rafecas, J. A. Fernandez-Lopez, X. Remesar, and M. Alemany
Plasma Leptin Turnover Rates in Lean and Obese Zucker Rats
Endocrinology, November 1, 1998; 139(11): 4466 - 4469.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. R. DOYLE, C. HERMANS, A. BERNARD, T. E. NICHOLAS, and A. D. BERSTEN
Clearance of Clara Cell Secretory Protein 16 (CC16) and Surfactant Proteins A and B from Blood in Acute Respiratory Failure
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(5): 1528 - 1535.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
J. W. Newcomer, G. Selke, A. K. Melson, J. Gross, G. P. Vogler, and S. Dagogo-Jack
Dose-Dependent Cortisol-Induced Increases in Plasma Leptin Concentration in Healthy Humans
Arch Gen Psychiatry, November 1, 1998; 55(11): 995 - 1000.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
F. Krempler, E. Hell, C. Winkler, D. Breban, and W. Patsch
Plasma Leptin Levels : Interaction of Obesity With a Common Variant of Insulin Receptor Substrate-1
Arterioscler. Thromb. Vasc. Biol., November 1, 1998; 18(11): 1686 - 1690.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. A. Pelleymounter, M. J. Cullen, D. Healy, R. Hecht, D. Winters, and M. McCaleb
Efficacy of exogenous recombinant murine leptin in lean and obese 10- to 12-mo-old female CD-1 mice
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R950 - R959.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. K. Karvonen, U. Pesonen, P. Heinonen, M. Laakso, A. Rissanen, H. Naukkarinen, R. Valve, M. I. J. Uusitupa, and M. Koulu
Identification of New Sequence Variants in the Leptin Gene
J. Clin. Endocrinol. Metab., September 1, 1998; 83(9): 3239 - 3242.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. D. Russell, R. N. Petersen, S. P. Rao, M. R. Ricci, A. Prasad, Y. Zhang, R. E. Brolin, and S. K. Fried
Leptin expression in adipose tissue from obese humans: depot-specific regulation by insulin and dexamethasone
Am J Physiol Endocrinol Metab, September 1, 1998; 275(3): E507 - E515.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
S. Ranganathan, M. Maffei, and P. A. Kern
Adipose tissue ob mRNA expression in humans: discordance with plasma leptin and relationship with adipose TNF{alpha} expression
J. Lipid Res., April 1, 1998; 39(4): 724 - 730.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. D. Eckert, C. Pomeroy, N. Raymond, P. F. Kohler, P. Thuras, and C. Y. Bowers
Leptin in Anorexia Nervosa
J. Clin. Endocrinol. Metab., March 1, 1998; 83(3): 791 - 795.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. M. Halleux, I. Servais, B. A. Reul, R. Detry, and S. M. Brichard
Multihormonal Control of ob Gene Expression and Leptin Secretion from Cultured Human Visceral Adipose Tissue: Increased Responsiveness to Glucocorticoids in Obesity
J. Clin. Endocrinol. Metab., March 1, 1998; 83(3): 902 - 910.
[Abstract] [Full Text]

Home page
 Clin. Chem.Home page
M. Landt, R. L. Gingerich, P. J. Havel, W. M. Mueller, B. Schoner, J. E. Hale, and M. L. Heiman
Radioimmunoassay of rat leptin: sexual dimorphism reversed from humans
Clin. Chem., March 1, 1998; 44(3): 565 - 570.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. A. Wadden, R. V. Considine, G. D. Foster, D. A. Anderson, D. B. Sarwer, and J. S. Caro
Short- and Long-Term Changes in Serum Leptin in Dieting Obese Women: Effects of Caloric Restriction and Weight Loss
J. Clin. Endocrinol. Metab., January 1, 1998; 83(1): 214 - 218.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
R. L. Leibel, W. K. Chung, and S. C. Chua Jr.
The Molecular Genetics of Rodent Single Gene Obesities
J. Biol. Chem., December 19, 1997; 272(51): 31937 - 31940.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
V. Mohamed-Ali, S. Goodrick, A. Rawesh, D. R. Katz, J. M. Miles, J. S. Yudkin, S. Klein, and S. W. Coppack
Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-{alpha}, in Vivo
J. Clin. Endocrinol. Metab., December 1, 1997; 82(12): 4196 - 4200.
[Abstract] [Full Text] [PDF]