HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Boyko, E. J. Articles by Fujimoto, W. Y. Search for Related Content PubMed PubMed Citation Articles by Boyko, E. J. Articles by Fujimoto, W. Y. Social Bookmarking                What's this?

Low insulin secretion and high fasting insulin and C-peptide levels predict increased visceral adiposity. 5-year follow-up among initially nondiabetic Japanese-American men

Insulin resistance and hyperinsulinemia occur more frequently in subjects with greater visceral adiposity, but it is not known whether these metabolic abnormalities precede or follow visceral fat accumulation. We prospectively studied the development of visceral adiposity in relation to fasting and stimulated insulin and C-peptide levels. We followed 137 nondiabetic, second-generation Japanese-American men for changes in visceral adiposity over 5 years. Intra-abdominal fat (IAF) area (square centimeters) was measured at the umbilicus by computed tomography at baseline and after 5 years. Plasma insulin and C-peptide levels were measured after an overnight fast and during an oral glucose tolerance test. Beta-cell function was measured by the insulin secretion ratio (30-0 min plasma insulin difference)/(30-0 min plasma glucose difference). After adjustment for baseline IAF in multiple linear regression models, baseline fasting insulin (coefficient = 0.241, P = 0.048) and C-peptide (coefficient = 38.538, P < 0.001) levels were positively correlated, while the baseline insulin secretion ratio was negatively correlated with IAF change (coefficient = -0.099, P = 0.027). With IAF difference coded as a dichotomous variable (> 0 cm2 vs. < or = 0 cm2), the highest versus lowest tertile of baseline fasting insulin (odds ratio [OR] = 3.0, 95% CI 1.0-9.7) and fasting C-peptide (OR = 8.1, 95% CI 2.4-26.8) levels and the lowest versus highest tertile of the insulin secretion ratio (OR = 3.3, 95% CI 1.0-10.0) were associated with higher odds of IAF gain. Greater insulin resistance and reduced insulin secretion precede visceral fat accumulation in nondiabetic Japanese-American men.

CiteULike

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				T. Hayashi, E. J. Boyko, M. J. McNeely, D. L. Leonetti, S. E. Kahn, and W. Y. Fujimoto Visceral Adiposity, Not Abdominal Subcutaneous Fat Area, Is Associated With an Increase in Future Insulin Resistance in Japanese Americans Diabetes, May 1, 2008; 57(5): 1269 - 1275. [Abstract] [Full Text] [PDF]

				Z. T. Bloomgarden Diabetes and Obesity: Part 1 Diabetes Care, December 1, 2007; 30(12): 3145 - 3151. [Full Text] [PDF]

				J. Tong, W. Y. Fujimoto, S. E. Kahn, D. S. Weigle, M. J. McNeely, D. L. Leonetti, J. B. Shofer, and E. J. Boyko Insulin, C-Peptide, and Leptin Concentrations Predict Increased Visceral Adiposity at 5- and 10-Year Follow-Ups in Nondiabetic Japanese Americans Diabetes, April 1, 2005; 54(4): 985 - 990. [Abstract] [Full Text] [PDF]

				M. Hallschmid, C. Benedict, B. Schultes, H.-L. Fehm, J. Born, and W. Kern Intranasal Insulin Reduces Body Fat in Men but not in Women Diabetes, November 1, 2004; 53(11): 3024 - 3029. [Abstract] [Full Text] [PDF]

				S. H. Travers, B. W. Jeffers, and R. H. Eckel Insulin Resistance during Puberty and Future Fat Accumulation J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3814 - 3818. [Abstract] [Full Text] [PDF]

				M. J. Quon Limitations of the Fasting Glucose to Insulin Ratio as an Index of Insulin Sensitivity J. Clin. Endocrinol. Metab., October 1, 2001; 86(10): 4615 - 4617. [Full Text] [PDF]

				A. Katz, S. S. Nambi, K. Mather, A. D. Baron, D. A. Follmann, G. Sullivan, and M. J. Quon Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans J. Clin. Endocrinol. Metab., July 1, 2000; 85(7): 2402 - 2410. [Abstract] [Full Text]

				A. Colao, R. Pivonello, S. Spiezia, A. Faggiano, D. Ferone, M. Filippella, P. Marzullo, G. Cerbone, M. Siciliani, and G. Lombardi Persistence of Increased Cardiovascular Risk in Patients with Cushing's Disease after Five Years of Successful Cure J. Clin. Endocrinol. Metab., August 1, 1999; 84(8): 2664 - 2672. [Abstract] [Full Text]

				N. B. Ruderman, A. K. Saha, D. Vavvas, and L. A. Witters Malonyl-CoA, fuel sensing, and insulin resistance Am J Physiol Endocrinol Metab, January 1, 1999; 276(1): E1 - E18. [Abstract] [Full Text] [PDF]

				M. W. Schwartz and R. J. Seeley Neuroendocrine Responses to Starvation and Weight Loss N. Engl. J. Med., June 19, 1997; 336(25): 1802 - 1811. [Full Text] [PDF]