Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Owerbach, D.
Right arrow Articles by Gabbay, K. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Owerbach, D.
Right arrow Articles by Gabbay, K. H.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 46, Issue 6 1069-1074, Copyright © 1997 by American Diabetes Association

ARTICLES

Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31-35

D Owerbach, FJ Naya, MJ Tsai, SV Allander, DR Powell and KH Gabbay
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA. davido@mbcr.bcm.tmc.edu

Recent genome searches suggest a putative linkage of many loci to susceptibility to type I diabetes. The chromosome 2q31-35 region is reported to be linked to susceptibility to type I diabetes and is thought to contain several diabetes susceptibility loci. These candidate genes include the HOXD gene cluster, BETA2, CTLA4, CD28, IGFBP2, and IGFBP5. Association studies in populations and families are required to confirm and/or identify the actual susceptibility loci. We hereby report several previously unknown DNA polymorphisms for HOXD8, BETA2, and IGFBP5, which we have used along with previously known polymorphisms of HOXD8 and CTLA4 to test whether these candidate loci are the susceptibility genes on chromosome 2q31-35. Using a case-control design with a subsequent family-association approach to confirm associations, we find no evidence that these candidate genes are associated with susceptibility to type I diabetes.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
F. K. Kavvoura and J. P. A. Ioannidis
CTLA-4 Gene Polymorphisms and Susceptibility to Type 1 Diabetes Mellitus: A HuGE Review and Meta-Analysis
Am. J. Epidemiol., July 1, 2005; 162(1): 3 - 16.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. M. Anjos, M.-C. Tessier, and C. Polychronakos
Association of the Cytotoxic T Lymphocyte-Associated Antigen 4 Gene with Type 1 Diabetes: Evidence for Independent Effects of Two Polymorphisms on the Same Haplotype Block
J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6257 - 6265.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. Vella, J. M.M. Howson, B. J. Barratt, R. C.J. Twells, H. E. Rance, S. Nutland, E. Tuomilehto-Wolf, J. Tuomilehto, D. E. Undlien, K. S. Ronningen, et al.
Lack of Association of the Ala45Thr Polymorphism and Other Common Variants of the NeuroD Gene With Type 1 Diabetes
Diabetes, April 1, 2004; 53(4): 1158 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
S. Yamada, Y. Motohashi, T. Yanagawa, T. Maruyama, A. Kasuga, H. Hirose, K. Matsubara, A. Shimada, and T. Saruta
NeuroD/BETA2 Gene G->A Polymorphism May Affect Onset Pattern of Type 1 Diabetes in Japanese
Diabetes Care, August 1, 2001; 24(8): 1438 - 1441.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1997 by the American Diabetes Association.