Diabetes, Vol 46, Issue 6 1077-1080, Copyright © 1997 by American Diabetes Association

ARTICLES

Leptin receptor of Zucker fatty rat performs reduced signal transduction

T Yamashita, T Murakami, M Iida, M Kuwajima and K Shima
Department of Laboratory Medicine, School of Medicine, the University of Tokushima, Kawauchi-cho, Japan.

Zucker fatty (fa/fa) rats exhibit overt obesity, hypercholesterolemia, hyperlipidemia, and hyperglycemia as recessive traits. The fa mutation has been determined to be a missense mutation in the extracellular domain of the leptin receptor. We report herein the construction of CHO cells that stably express the fa-type leptin receptor and the characterization of this receptor using mRNA expression levels of the immediate early genes, c-fos, c-jun, and jun-B, which are induced by leptin as a criterion of signal transduction. The fa-type receptor not only exhibits a slightly reduced leptin-binding affinity, but also performs reduced signal transduction.
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