Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Muoio, D. M.
Right arrow Articles by Dohn, G. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Muoio, D. M.
Right arrow Articles by Dohn, G. L.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 46, Issue 8 1360-1363, Copyright © 1997 by American Diabetes Association

ARTICLES

Leptin directly alters lipid partitioning in skeletal muscle

DM Muoio, GL Dohm, FT Fiedorek, EB Tapscott, RA Coleman and GL Dohn
Department of Nutrition, University of North Carolina at Chapel Hill, 27599, USA.

Leptin, an adipocyte-derived hormone that directly regulates both adiposity and energy homeostasis, decreases food intake and appears to partition metabolic fuels toward utilization and away from storage. Because skeletal muscle expresses the leptin receptor and plays a major role in determining energy metabolism, we studied leptin's effects on glucose and fatty acid (FA) metabolism in isolated mouse soleus and extensor digitorum longus (EDL) muscles. One muscle from each animal served as a basal control. The contralateral muscle was treated with insulin (10 mU/ml), leptin (0.01-10 microg/ml), or insulin plus leptin, and incorporation of [14C]glucose or [14C]oleate into CO2 and into either glycogen or triacylglycerol (TAG) was determined. Leptin increased soleus muscle FA oxidation by 42% (P < 0.001) and decreased incorporation of FA into TAG by 35% (P < 0.01) in a dose-dependent manner. In contrast, insulin decreased soleus muscle FA oxidation by 40% (P < 0.001) and increased incorporation into TAG by 70% (P < 0.001). When both hormones were present, leptin attenuated both the antioxidative and the lipogenic effects of insulin by 50%. Less pronounced hormone effects were observed in EDL muscle. Leptin did not alter insulin-stimulated muscle glucose metabolism. These data demonstrate that leptin has direct and acute effects on skeletal muscle.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. L. Mullen, A. C. Smith, K. A. Junkin, and D. J. Dyck
Globular adiponectin resistance develops independently of impaired insulin-stimulated glucose transport in soleus muscle from high-fat-fed rats
Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E83 - E90.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. Guerra, A. Santana, T. Fuentes, S. Delgado-Guerra, A. Cabrera-Socorro, C. Dorado, and J. A. L. Calbet
Leptin receptors in human skeletal muscle
J Appl Physiol, May 1, 2007; 102(5): 1786 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. B. Flowers, A. T. Oler, S. T. Nadler, Y. Choi, K. L. Schueler, B. S. Yandell, C. M. Kendziorski, and A. D. Attie
Abdominal obesity in BTBR male mice is associated with peripheral but not hepatic insulin resistance
Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E936 - E945.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. J. Jurczak, A. M. Danos, V. R. Rehrmann, M. B. Allison, C. C. Greenberg, and M. J. Brady
Transgenic overexpression of protein targeting to glycogen markedly increases adipocytic glycogen storage in mice
Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E952 - E963.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. C. Towler and D. G. Hardie
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
Circ. Res., February 16, 2007; 100(3): 328 - 341.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
A. Bonen, A. Chabowski, J. J. F. P Luiken, and J. F. C. Glatz
Mechanisms and Regulation of Protein-Mediated Cellular Fatty Acid Uptake: Molecular, Biochemical, and Physiological Evidence
Physiology, February 1, 2007; 22(1): 15 - 28.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. R. Steinberg, A. J. McAinch, M. B. Chen, P. E. O'Brien, J. B. Dixon, D. Cameron-Smith, and B. E. Kemp
The Suppressor of Cytokine Signaling 3 Inhibits Leptin Activation of AMP-Kinase in Cultured Skeletal Muscle of Obese Humans
J. Clin. Endocrinol. Metab., September 1, 2006; 91(9): 3592 - 3597.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. L. Martin, T. Alquier, K. Asakura, N. Furukawa, F. Preitner, and B. B. Kahn
Diet-induced Obesity Alters AMP Kinase Activity in Hypothalamus and Skeletal Muscle
J. Biol. Chem., July 14, 2006; 281(28): 18933 - 18941.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. A. Collier, C. R. Bruce, A. C. Smith, G. Lopaschuk, and D. J. Dyck
Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle
Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E182 - E189.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. B. O'Leary, C. M. Marchetti, R. K. Krishnan, B. P. Stetzer, F. Gonzalez, and J. P. Kirwan
Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat
J Appl Physiol, May 1, 2006; 100(5): 1584 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Ukropec, R. V. P. Anunciado, Y. Ravussin, and L. P. Kozak
Leptin Is Required for Uncoupling Protein-1-Independent Thermogenesis during Cold Stress
Endocrinology, May 1, 2006; 147(5): 2468 - 2480.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
W. Huang, N. Dedousis, A. Bandi, G. D. Lopaschuk, and R. M. O'Doherty
Liver Triglyceride Secretion and Lipid Oxidative Metabolism Are Rapidly Altered by Leptin in Vivo
Endocrinology, March 1, 2006; 147(3): 1480 - 1487.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Toyoshima, O. Gavrilova, S. Yakar, W. Jou, S. Pack, Z. Asghar, M. B. Wheeler, and D. LeRoith
Leptin Improves Insulin Resistance and Hyperglycemia in a Mouse Model of Type 2 Diabetes
Endocrinology, September 1, 2005; 146(9): 4024 - 4035.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
T. Tanaka, S. Hidaka, H. Masuzaki, S. Yasue, Y. Minokoshi, K. Ebihara, H. Chusho, Y. Ogawa, T. Toyoda, K. Sato, et al.
Skeletal Muscle AMP-Activated Protein Kinase Phosphorylation Parallels Metabolic Phenotype in Leptin Transgenic Mice Under Dietary Modification
Diabetes, August 1, 2005; 54(8): 2365 - 2374.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K De Bock, E. A Richter, A. P Russell, B. O Eijnde, W Derave, M Ramaekers, E Koninckx, B Leger, J Verhaeghe, and P Hespel
Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans
J. Physiol., April 15, 2005; 564(2): 649 - 660.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
R. Barazzoni, M. Zanetti, A. Bosutti, G. Biolo, L. Vitali-Serdoz, M. Stebel, and G. Guarnieri
Moderate Caloric Restriction, But Not Physiological Hyperleptinemia Per Se, Enhances Mitochondrial Oxidative Capacity in Rat Liver and Skeletal Muscle--Tissue-Specific Impact on Tissue Triglyceride Content and AKT Activation
Endocrinology, April 1, 2005; 146(4): 2098 - 2106.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Gutierrez-Juarez, S. Obici, and L. Rossetti
Melanocortin-independent Effects of Leptin on Hepatic Glucose Fluxes
J. Biol. Chem., November 26, 2004; 279(48): 49704 - 49715.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. R. Bruce and D. J. Dyck
Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-{alpha}
Am J Physiol Endocrinol Metab, October 1, 2004; 287(4): E616 - E621.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. R. Steinberg, A. C. Smith, B. J. W. van Denderen, Z. Chen, S. Murthy, D. J. Campbell, G. J. F. Heigenhauser, D. J. Dyck, and B. E. Kemp
AMP-Activated Protein Kinase Is Not Down-Regulated in Human Skeletal Muscle of Obese Females
J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4575 - 4580.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Guzman, J. Lo Verme, J. Fu, F. Oveisi, C. Blazquez, and D. Piomelli
Oleoylethanolamide Stimulates Lipolysis by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor {alpha} (PPAR-{alpha})
J. Biol. Chem., July 2, 2004; 279(27): 27849 - 27854.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. R. Commerford, L. Peng, J. J. Dube, and R. M. O'Doherty
In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R218 - R227.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
I. Leclerc, W. W. Woltersdorf, G. da Silva Xavier, R. L. Rowe, S. E. Cross, G. S. Korbutt, R. V. Rajotte, R. Smith, and G. A. Rutter
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion
Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E1023 - E1031.
[Abstract] [Full Text] [PDF]

Home page
 Recent Prog Horm ResHome page
C. Bjorbaek and B. B. Kahn
Leptin Signaling in the Central Nervous System and the Periphery
Recent Prog. Horm. Res., January 1, 2004; 59(1): 305 - 331.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. R. Steinberg, A. C. Smith, S. Wormald, P. Malenfant, C. Collier, and D. J. Dyck
Endurance training partially reverses dietary-induced leptin resistance in rodent skeletal muscle
Am J Physiol Endocrinol Metab, January 1, 2004; 286(1): E57 - E63.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
T. G. Ramsay
Porcine leptin inhibits protein breakdown and stimulates fatty acid oxidation in C2C12 myotubes
J Anim Sci, December 1, 2003; 81(12): 3046 - 3051.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Alon, J. M. Friedman, and N. D. Socci
Cytokine-induced Patterns of Gene Expression in Skeletal Muscle Tissue
J. Biol. Chem., August 22, 2003; 278(34): 32324 - 32334.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. J. Watt, G. R. Steinberg, G. J. F. Heigenhauser, L. L. Spriet, and D. J. Dyck
Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid
Am J Physiol Endocrinol Metab, August 1, 2003; 285(2): E412 - E419.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Gurnell, D. B. Savage, V. K. K. Chatterjee, and S. O'Rahilly
The Metabolic Syndrome: Peroxisome Proliferator-Activated Receptor {gamma} and Its Therapeutic Modulation
J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2412 - 2421.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. L. Dobbins, L. S. Szczepaniak, W. Zhang, and J. D. McGarry
Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion
Am J Physiol Endocrinol Metab, April 1, 2003; 284(4): E778 - E787.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Munoz and B. A. Gower
Relationship between Serum Leptin Concentration and Low-Density Muscle in Postmenopausal Women
J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1157 - 1161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. R. Steinberg, J. W. E. Rush, and D. J. Dyck
AMPK expression and phosphorylation are increased in rodent muscle after chronic leptin treatment
Am J Physiol Endocrinol Metab, March 1, 2003; 284(3): E648 - E654.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. D. Kriketos, S. M. Furler, S. K. Gan, A. M. Poynten, D. J. Chisholm, and L. V. Campbell
Multiple Indexes of Lipid Availability Are Independently Related to Whole Body Insulin Action in Healthy Humans
J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 793 - 798.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. Perseghin, P. Scifo, M. Danna, A. Battezzati, S. Benedini, E. Meneghini, A. Del Maschio, and L. Luzi
Normal insulin sensitivity and IMCL content in overweight humans are associated with higher fasting lipid oxidation
Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E556 - E564.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. L. Atkinson, M. A. Fischer, and G. D. Lopaschuk
Leptin Activates Cardiac Fatty Acid Oxidation Independent of Changes in the AMP-activated Protein Kinase-Acetyl-CoA Carboxylase-Malonyl-CoA Axis
J. Biol. Chem., August 9, 2002; 277(33): 29424 - 29430.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. C. Chen, Z. Ladha, and R. V. Farese Jr.
Deficiency of Acyl Coenzyme A:Diacylglycerol Acyltransferase 1 Increases Leptin Sensitivity in Murine Obesity Models
Endocrinology, August 1, 2002; 143(8): 2893 - 2898.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
R. B. CEDDIA, H. A. KOISTINEN, J. R. ZIERATH, and G. SWEENEY
Analysis of paradoxical observations on the association between leptin and insulin resistance
FASEB J, August 1, 2002; 16(10): 1163 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. P. Kirwan, S. Hauguel-De Mouzon, J. Lepercq, J.-C. Challier, L. Huston-Presley, J. E. Friedman, S. C. Kalhan, and P. M. Catalano
TNF-{alpha} Is a Predictor of Insulin Resistance in Human Pregnancy
Diabetes, July 1, 2002; 51(7): 2207 - 2213.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. J. Yee and L. P. Turcotte
Insulin fails to alter plasma LCFA metabolism in muscle perfused at similar glucose uptake
Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E73 - E77.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. R. Steinberg, M. L. Parolin, G. J. F. Heigenhauser, and D. J. Dyck
Leptin increases FA oxidation in lean but not obese human skeletal muscle: evidence of peripheral leptin resistance
Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E187 - E192.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. R. Steinberg, D. J. Dyck, J. Calles-Escandon, N. N. Tandon, J. J. F. P. Luiken, J. F. C. Glatz, and A. Bonen
Chronic Leptin Administration Decreases Fatty Acid Uptake and Fatty Acid Transporters in Rat Skeletal Muscle
J. Biol. Chem., March 8, 2002; 277(11): 8854 - 8860.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Ozata, C. Oktenli, M. Gulec, T. Ozgurtas, F. Bulucu, K. Caglar, N. Bingol, A. Vural, and I. C. Ozdemir
Increased Fasting Plasma Acylation-Stimulating Protein Concentrations in Nephrotic Syndrome
J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 853 - 858.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. P. Reidy and J.-M. Weber
Accelerated substrate cycling: a new energy-wasting role for leptin in vivo
Am J Physiol Endocrinol Metab, February 1, 2002; 282(2): E312 - E317.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
I. M. Lopes, L. Forga, and J. A. Martinez
Effects of Leptin Resistance on Acute Fuel Metabolism after a High Carbohydrate Load in Lean and Overweight Young Men
J. Am. Coll. Nutr., December 1, 2001; 20(6): 643 - 648.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
T. S. Herrmann, M. L. Bean, T. M. Black, P. Wang, and R. A. Coleman
High Glycemic Index Carbohydrate Diet Alters the Diurnal Rhythm of Leptin But Not Insulin Concentrations
Experimental Biology and Medicine, December 1, 2001; 226(11): 1037 - 1044.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Wang, S. Obici, K. Morgan, N. Barzilai, Z. Feng, and L. Rossetti
Overfeeding Rapidly Induces Leptin and Insulin Resistance
Diabetes, December 1, 2001; 50(12): 2786 - 2791.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. J. Dyck, G. Steinberg, and A. Bonen
Insulin increases FA uptake and esterification but reduces lipid utilization in isolated contracting muscle
Am J Physiol Endocrinol Metab, September 1, 2001; 281(3): E600 - E607.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Lau, W. D. Blinn, A. Bonen, and D. J. Dyck
Stimulatory effects of leptin and muscle contraction on fatty acid metabolism are not additive
Am J Physiol Endocrinol Metab, July 1, 2001; 281(1): E122 - E129.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Arai, K. Kim, K. Kaneko, M. Iketani, A. Otagiri, N. Yamauchi, and T. Shibasaki
Nicotine infusion alters leptin and uncoupling protein 1 mRNA expression in adipose tissues of rats
Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E867 - E876.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Fabris, E. Nisoli, A. M. Lombardi, C. Tonello, R. Serra, M. Granzotto, I. Cusin, F. Rohner-Jeanrenaud, G. Federspil, M. O. Carruba, et al.
Preferential Channeling of Energy Fuels Toward Fat Rather Than Muscle During High Free Fatty Acid Availability in Rats
Diabetes, March 1, 2001; 50(3): 601 - 608.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
Y. Chen and M. L. Heiman
Increased weight gain after ovariectomy is not a consequence of leptin resistance
Am J Physiol Endocrinol Metab, February 1, 2001; 280(2): E315 - E322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. B. Yaspelkis III, J. R. Davis, M. Saberi, T. L. Smith, R. Jazayeri, M. Singh, V. Fernandez, B. Trevino, N. Chinookoswong, J. Wang, et al.
Leptin administration improves skeletal muscle insulin responsiveness in diet-induced insulin-resistant rats
Am J Physiol Endocrinol Metab, January 1, 2001; 280(1): E130 - E142.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. R. Steinberg and D. J. Dyck
Development of leptin resistance in rat soleus muscle in response to high-fat diets
Am J Physiol Endocrinol Metab, December 1, 2000; 279(6): E1374 - E1382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W.-N. P. Lee, S. Bassilian, S. Lim, and L. G. Boros
Loss of regulation of lipogenesis in the Zucker diabetic (ZDF) rat
Am J Physiol Endocrinol Metab, August 1, 2000; 279(2): E425 - E432.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y.-B. Kim, S. Uotani, D. D. Pierroz, J. S. Flier, and B. B. Kahn
In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin
Endocrinology, July 1, 2000; 141(7): 2328 - 2339.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. M. Bryson, J. L. Phuyal, V. Swan, and I. D. Caterson
Leptin has acute effects on glucose and lipid metabolism in both lean and gold thioglucose-obese mice
Am J Physiol Endocrinol Metab, September 1, 1999; 277(3): E417 - E422.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. M. O'Doherty, P. R. Anderson, A. Z. Zhao, K. E. Bornfeldt, and C. B. Newgard
Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition
Am J Physiol Endocrinol Metab, September 1, 1999; 277(3): E544 - E550.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Rouru, I. Cusin, K. E. Zakrzewska, B. Jeanrenaud, and F. Rohner-Jeanrenaud
Effects of Intravenously Infused Leptin on Insulin Sensitivity and on the Expression of Uncoupling Proteins in Brown Adipose Tissue
Endocrinology, August 1, 1999; 140(8): 3688 - 3692.
[Abstract] [Full Text]

Home page