Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hallakou, S.
Right arrow Articles by Ferre, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hallakou, S.
Right arrow Articles by Ferre, P.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 46, Issue 9 1393-1399, Copyright © 1997 by American Diabetes Association

ARTICLES

Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat

S Hallakou, L Doare, F Foufelle, M Kergoat, M Guerre-Millo, MF Berthault, I Dugail, J Morin, J Auwerx and P Ferre
Institut National de la Sante et de la Recherche Medicale, Unit 465, Paris, France.

Thiazolidinediones are potent antidiabetic compounds, in both animal and human models, which act by enhancing peripheral sensitivity to insulin. Thiazolidinediones are high-affinity ligands for peroxisome proliferator-activated receptor-gamma, a key factor for adipocyte differentiation, and they are efficient promoters of adipocyte differentiation in vitro. Thus, it could be questioned whether a thiazolidinedione therapy aimed at improving insulin sensitivity would promote the recruitment of new adipocytes in vivo. To address this problem, we have studied the in vivo effect of pioglitazone on glucose metabolism and gene expression in the adipose tissue of an animal model of obesity with insulin resistance, the obese Zucker (fa/fa) rat. Pioglitazone markedly improves insulin action in the obese Zucker (fa/fa) rat, but doubles its weight gain after 4 weeks of treatment. The drug induces a large increase of glucose utilization in adipose tissue, where it stimulates the expression of genes involved in lipid metabolism such as the insulin-responsive GLUT, fatty acid synthase, and phosphoenolpyruvate carboxykinase genes, but decreases the expression of the ob gene. These changes are related to both an enhanced adipocyte differentiation, as shown by the large increase in the number of small adipocytes in the retroperitoneal fat pad, and a direct effect of pioglitazone on specific gene expression (phosphoenolpyruvate carboxykinase and ob genes) in mature adipocytes.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
M. C. Carmona, K. Louche, B. Lefebvre, A. Pilon, N. Hennuyer, V. Audinot-Bouchez, C. Fievet, G. Torpier, P. Formstecher, P. Renard, et al.
S 26948: a New Specific Peroxisome Proliferator Activated Receptor {gamma} Modulator With Potent Antidiabetes and Antiatherogenic Effects
Diabetes, November 1, 2007; 56(11): 2797 - 2808.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Buchmann, C. Meyer, S. Neschen, R. Augustin, K. Schmolz, R. Kluge, H. Al-Hasani, H. Jurgens, K. Eulenberg, R. Wehr, et al.
Ablation of the Cholesterol Transporter Adenosine Triphosphate-Binding Cassette Transporter G1 Reduces Adipose Cell Size and Protects against Diet-Induced Obesity
Endocrinology, April 1, 2007; 148(4): 1561 - 1573.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
G. Ranganathan, R. Unal, I. Pokrovskaya, A. Yao-Borengasser, B. Phanavanh, B. Lecka-Czernik, N. Rasouli, and P. A. Kern
The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment
J. Lipid Res., November 1, 2006; 47(11): 2444 - 2450.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. Gastaldelli, Y. Miyazaki, A. Mahankali, R. Berria, M. Pettiti, E. Buzzigoli, E. Ferrannini, and R. A. DeFronzo
The Effect of Pioglitazone on the Liver: Role of adiponectin
Diabetes Care, October 1, 2006; 29(10): 2275 - 2281.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
F. Grun, H. Watanabe, Z. Zamanian, L. Maeda, K. Arima, R. Cubacha, D. M. Gardiner, J. Kanno, T. Iguchi, and B. Blumberg
Endocrine-Disrupting Organotin Compounds Are Potent Inducers of Adipogenesis in Vertebrates
Mol. Endocrinol., September 1, 2006; 20(9): 2141 - 2155.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
T. Fujimura, C. Kimura, T. Oe, Y. Takata, H. Sakuma, I. Aramori, and S. Mutoh
A Selective Peroxisome Proliferator-Activated Receptor {gamma} Modulator with Distinct Fat Cell Regulation Properties
J. Pharmacol. Exp. Ther., August 1, 2006; 318(2): 863 - 871.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
N. K. LeBrasseur, M. Kelly, T.-S. Tsao, S. R. Farmer, A. K. Saha, N. B. Ruderman, and E. Tomas
Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues
Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E175 - E181.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
E. S. Kang, B. S. Cha, H. J. Kim, H. J. Kim, S. H. Kim, K. Y. Hur, H. J. Lee, W. S. Shim, C. W. Ahn, and H. C. Lee
The 11482G>A Polymorphism in the Perilipin Gene Is Associated With Weight Gain With Rosiglitazone Treatment in Type 2 Diabetes.
Diabetes Care, June 1, 2006; 29(6): 1320 - 1324.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
B. Desvergne, L. Michalik, and W. Wahli
Transcriptional Regulation of Metabolism
Physiol Rev, April 1, 2006; 86(2): 465 - 514.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. Knouff and J. Auwerx
Peroxisome Proliferator-Activated Receptor-{gamma} Calls for Activation in Moderation: Lessons from Genetics and Pharmacology
Endocr. Rev., December 1, 2004; 25(6): 899 - 918.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Rieusset, J. Seydoux, S. I. Anghel, P. Escher, L. Michalik, N. Soon Tan, D. Metzger, P. Chambon, W. Wahli, and B. Desvergne
Altered Growth in Male Peroxisome Proliferator-Activated Receptor {gamma} (PPAR{gamma}) Heterozygous Mice: Involvement of PPAR{gamma} in a Negative Feedback Regulation of Growth Hormone Action
Mol. Endocrinol., October 1, 2004; 18(10): 2363 - 2377.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Y. Miyazaki, A. Mahankali, E. Wajcberg, M. Bajaj, L. J. Mandarino, and R. A. DeFronzo
Effect of Pioglitazone on Circulating Adipocytokine Levels and Insulin Sensitivity in Type 2 Diabetic Patients
J. Clin. Endocrinol. Metab., September 1, 2004; 89(9): 4312 - 4319.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
I. Bogacka, H. Xie, G. A. Bray, and S. R. Smith
The Effect of Pioglitazone on Peroxisome Proliferator-Activated Receptor-{gamma} Target Genes Related to Lipid Storage In Vivo
Diabetes Care, July 1, 2004; 27(7): 1660 - 1667.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. Desvergne, L. Michalik, and W. Wahli
Be Fit or Be Sick: Peroxisome Proliferator-Activated Receptors Are Down the Road
Mol. Endocrinol., June 1, 2004; 18(6): 1321 - 1332.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Cariou, C. Postic, P. Boudou, R. Burcelin, C. R. Kahn, J. Girard, A.-F. Burnol, and F. Mauvais-Jarvis
Cellular and Molecular Mechanisms of Adipose Tissue Plasticity in Muscle Insulin Receptor Knockout Mice
Endocrinology, April 1, 2004; 145(4): 1926 - 1932.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
Y.-H. Yu and H. Zhu
Chronological changes in metabolism and functions of cultured adipocytes: a hypothesis for cell aging in mature adipocytes
Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E402 - E410.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. Bays, L. Mandarino, and R. A. DeFronzo
Role of the Adipocyte, Free Fatty Acids, and Ectopic Fat in Pathogenesis of Type 2 Diabetes Mellitus: Peroxisomal Proliferator-Activated Receptor Agonists Provide a Rational Therapeutic Approach
J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 463 - 478.
[Full Text] [PDF]

Home page
 EndocrinologyHome page
K. M. Ogilvie, R. Saladin, T. R. Nagy, M. S. Urcan, R. A. Heyman, and M. D. Leibowitz
Activation of the Retinoid X Receptor Suppresses Appetite in the Rat
Endocrinology, February 1, 2004; 145(2): 565 - 573.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. Ferre
The Biology of Peroxisome Proliferator-Activated Receptors: Relationship With Lipid Metabolism and Insulin Sensitivity
Diabetes, February 1, 2004; 53(90001): S43 - 50.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Bajaj, S. Suraamornkul, P. Piper, L. J. Hardies, L. Glass, E. Cersosimo, T. Pratipanawatr, Y. Miyazaki, and R. A. DeFronzo
Decreased Plasma Adiponectin Concentrations Are Closely Related to Hepatic Fat Content and Hepatic Insulin Resistance in Pioglitazone-Treated Type 2 Diabetic Patients
J. Clin. Endocrinol. Metab., January 1, 2004; 89(1): 200 - 206.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-J. Cho, H.-E. Moon, H. Moini, L. Packer, D.-Y. Yoon, and A.-S. Chung
{alpha}-Lipoic Acid Inhibits Adipocyte Differentiation by Regulating Pro-adipogenic Transcription Factors via Mitogen-activated Protein Kinase Pathways
J. Biol. Chem., September 12, 2003; 278(37): 34823 - 34833.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Armoni, N. Kritz, C. Harel, F. Bar-Yoseph, H. Chen, M. J. Quon, and E. Karnieli
Peroxisome Proliferator-activated Receptor-{gamma} Represses GLUT4 Promoter Activity in Primary Adipocytes, and Rosiglitazone Alleviates This Effect
J. Biol. Chem., August 15, 2003; 278(33): 30614 - 30623.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
L. Granlund, L. K. Juvet, J. I. Pedersen, and H. I. Nebb
Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPAR{gamma} modulator
J. Lipid Res., August 1, 2003; 44(8): 1441 - 1452.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
Y. Miyazaki, H. He, L. J. Mandarino, and R. A. DeFronzo
Rosiglitazone Improves Downstream Insulin Receptor Signaling in Type 2 Diabetic Patients
Diabetes, August 1, 2003; 52(8): 1943 - 1950.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Rossmeisl, J. S. Rim, R. A. Koza, and L. P. Kozak
Variation in Type 2 Diabetes-Related Traits in Mouse Strains Susceptible to Diet-Induced Obesity
Diabetes, August 1, 2003; 52(8): 1958 - 1966.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Bajaj, S. Suraamornkul, T. Pratipanawatr, L. J. Hardies, W. Pratipanawatr, L. Glass, E. Cersosimo, Y. Miyazaki, and R. A. DeFronzo
Pioglitazone Reduces Hepatic Fat Content and Augments Splanchnic Glucose Uptake in Patients With Type 2 Diabetes
Diabetes, June 1, 2003; 52(6): 1364 - 1370.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Yajima, H. Hirose, H. Fujita, Y. Seto, H. Fujita, K. Ukeda, K. Miyashita, T. Kawai, Y. Yamamoto, T. Ogawa, et al.
Combination therapy with PPARgamma and PPARalpha agonists increases glucose-stimulated insulin secretion in db/db mice
Am J Physiol Endocrinol Metab, May 1, 2003; 284(5): E966 - E971.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. A. Phillips, T. P. Ciaraldi, A. P.S. Kong, R. Bandukwala, V. Aroda, L. Carter, S. Baxi, S. R. Mudaliar, and R. R. Henry
Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy
Diabetes, March 1, 2003; 52(3): 667 - 674.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J.-M. Ye, G. Frangioudakis, M. A. Iglesias, S. M. Furler, B. Ellis, N. Dzamko, G. J. Cooney, and E. W. Kraegen
Prior Thiazolidinedione Treatment Preserves Insulin Sensitivity in Normal Rats during Acute Fatty Acid Elevation: Role of the Liver
Endocrinology, December 1, 2002; 143(12): 4527 - 4535.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
M. St. John Sutton, M. Rendell, P. Dandona, J. F. Dole, K. Murphy, R. Patwardhan, J. Patel, and M. Freed
A Comparison of the Effects of Rosiglitazone and Glyburide on Cardiovascular Function and Glycemic Control in Patients With Type 2 Diabetes
Diabetes Care, November 1, 2002; 25(11): 2058 - 2064.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Rieusset, F. Touri, L. Michalik, P. Escher, B. Desvergne, E. Niesor, and W. Wahli
A New Selective Peroxisome Proliferator-Activated Receptor {gamma} Antagonist with Antiobesity and Antidiabetic Activity
Mol. Endocrinol., November 1, 2002; 16(11): 2628 - 2644.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. Sewter, F. Blows, R. Considine, A. Vidal-Puig, and S. O'Rahilly
Differential Effects of Adiposity on Peroxisomal Proliferator-Activated Receptor {gamma}1 and {gamma}2 Messenger Ribonucleic Acid Expression in Human Adipocytes
J. Clin. Endocrinol. Metab., September 1, 2002; 87(9): 4203 - 4207.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Y. Miyazaki, A. Mahankali, M. Matsuda, S. Mahankali, J. Hardies, K. Cusi, L. J. Mandarino, and R. A. DeFronzo
Effect of Pioglitazone on Abdominal Fat Distribution and Insulin Sensitivity in Type 2 Diabetic Patients
J. Clin. Endocrinol. Metab., June 1, 2002; 87(6): 2784 - 2791.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
L. Madsen, M. Guerre-Millo, E. N. Flindt, K. Berge, K. J. Tronstad, E. Bergene, E. Sebokova, A. C. Rustan, J. Jensen, S. Mandrup, et al.
Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance
J. Lipid Res., May 1, 2002; 43(5): 742 - 750.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. W. Valyasevi, D. A. Harteneck, C. M. Dutton, and R. S. Bahn
Stimulation of Adipogenesis, Peroxisome Proliferator-Activated Receptor-{gamma} (PPAR{gamma}), and Thyrotropin Receptor by PPAR{gamma} Agonist in Human Orbital Preadipocyte Fibroblasts
J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2352 - 2358.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
T. Albrektsen, K. S. Frederiksen, W. E. Holmes, E. Boel, K. Taylor, and J. Fleckner
Novel Genes Regulated by the Insulin Sensitizer Rosiglitazone During Adipocyte Differentiation
Diabetes, April 1, 2002; 51(4): 1042 - 1051.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Y. Miyazaki, M. Matsuda, and R. A. DeFronzo
Dose-Response Effect of Pioglitazone on Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes
Diabetes Care, March 1, 2002; 25(3): 517 - 523.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. J. de Souza, M. Eckhardt, K. Gagen, M. Dong, W. Chen, D. Laurent, and B. F. Burkey
Effects of Pioglitazone on Adipose Tissue Remodeling Within the Setting of Obesity and Insulin Resistance
Diabetes, August 1, 2001; 50(8): 1863 - 1871.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
P. Raskin, M. Rendell, M. C. Riddle, J. F. Dole, M. I. Freed, and J. Rosenstock
A Randomized Trial of Rosiglitazone Therapy in Patients With Inadequately Controlled Insulin-Treated Type 2 Diabetes
Diabetes Care, July 1, 2001; 24(7): 1226 - 1232.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Y. Miyazaki, A. Mahankali, M. Matsuda, L. Glass, S. Mahankali, E. Ferrannini, K. Cusi, L. J. Mandarino, and R. A. DeFronzo
Improved Glycemic Control and Enhanced Insulin Sensitivity in Type 2 Diabetic Subjects Treated With Pioglitazone
Diabetes Care, April 1, 2001; 24(4): 710 - 719.
[Abstract] [Full Text]

Home page
 Mol. Pharmacol.Home page
H. S. Ahuja, S. Liu, D. L. Crombie, M. Boehm, M. D. Leibowitz, R. A. Heyman, C. Depre, L. Nagy, P. Tontonoz, and P. J. A. Davies
Differential Effects of Rexinoids and Thiazolidinediones on Metabolic Gene Expression in Diabetic Rodents
Mol. Pharmacol., April 1, 2001; 59(4): 765 - 773.
[Abstract] [Full Text]

Home page
 DiabetesHome page
T. Ogihara, T. Asano, K. Ando, Y. Chiba, N. Sekine, H. Sakoda, M. Anai, Y. Onishi, M. Fujishiro, H. Ono, et al.
Insulin Resistance With Enhanced Insulin Signaling in High-Salt Diet-Fed Rats
Diabetes, March 1, 2001; 50(3): 573 - 583.
[Abstract] [Full Text]

Home page
 Mol. Pharmacol.Home page
T. Albrektsen and J. Fleckner
The Transcription Factor Fos-Related Antigen 1 Is Induced by Thiazolidinediones During Differentiation of 3T3-L1 Cells
Mol. Pharmacol., March 1, 2001; 59(3): 567 - 575.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
I. Gabriely, R. Wozniak, M. Hawkins, and H. Shamoon
Troglitazone Amplifies Counterregulatory Responses to Hypoglycemia in Nondiabetic Subjects
J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 521 - 528.
[Abstract] [Full Text]

Home page
 Diabetes CareHome page
L. S. Phillips, G. Grunberger, E. Miller, R. Patwardhan, E. B. Rappaport, and A. Salzman
Once- and Twice-Daily Dosing With Rosiglitazone Improves Glycemic Control in Patients With Type 2 Diabetes
Diabetes Care, February 1, 2001; 24(2): 308 - 315.
[Abstract] [Full Text]

Home page
 AIDS Clin CareHome page
Insulin Resistance in HIV Lipodystrophy Syndrome
AIDS Clinical Care, February 1, 2001; 2001(201): 7 - 7.
[Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
H. E. Lebovitz, J. F. Dole, R. Patwardhan, E. B. Rappaport, and M. I. Freed
Rosiglitazone Monotherapy Is Effective in Patients with Type 2 Diabetes
J. Clin. Endocrinol. Metab., January 1, 2001; 86(1): 280 - 288.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
S. Matthaei, M. Stumvoll, M. Kellerer, and H.-U. Häring
Pathophysiology and Pharmacological Treatment of Insulin Resistance
Endocr. Rev., December 1, 2000; 21(6): 585 - 618.
[Abstract] [Full Text]

Home page
 Mol. Endocrinol.Home page
R. Mukherjee, P. A. Hoener, L. Jow, J. Bilakovics, K. Klausing, D. E. Mais, A. Faulkner, G. E. Croston, and J. R. Paterniti Jr.
A Selective Peroxisome Proliferator-Activated Receptor-{gamma} (PPAR{gamma}) Modulator Blocks Adipocyte Differentiation but Stimulates Glucose Uptake in 3T3-L1 Adipocytes
Mol. Endocrinol., September 1, 2000; 14(9): 1425 - 1433.
[Abstract] [Full Text]

Home page
 J. Lipid Res.Home page
Y.-C. Kim, F. E. Gomez, B. G. Fox, and J. M. Ntambi
Differential regulation of the stearoyl-CoA desaturase genes by thiazolidinediones in 3T3-L1 adipocytes
J. Lipid Res., August 1, 2000; 41(8): 1310 - 1316.
[Abstract] [Full Text]

Home page
 JAMAHome page
V. Fonseca, J. Rosenstock, R. Patwardhan, and A. Salzman
Effect of Metformin and Rosiglitazone Combination Therapy in Patients With Type 2 Diabetes Mellitus: A Randomized Controlled Trial
JAMA, April 5, 2000; 283(13): 1695 - 1702.
[Abstract] [Full Text] [PDF]

Home page
 Cell Growth Differ.Home page
R. Butler, S. H. Mitchell, D. J. Tindall, and C. Y. F. Young
Nonapoptotic Cell Death Associated with S-Phase Arrest of Prostate Cancer Cells via the Peroxisome Proliferator-activated Receptor {{gamma}} Ligand, 15-Deoxy-{{Delta}}12,14- prostaglandin J2
Cell Growth Differ., January 1, 2000; 11(1): 49 - 61.
[Abstract] [Full Text]

Home page
 ANN INTERN MEDHome page
R. A. DeFronzo
Pharmacologic Therapy for Type 2 Diabetes Mellitus
Ann Intern Med, August 17, 1999; 131(4): 281 - 303.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
U. Edvardsson, M. Bergström, M. Alexandersson, K. Bamberg, B. Ljung, and B. Dahllöf
Rosiglitazone (BRL49653), a PPAR{gamma}-selective agonist, causes peroxisome proliferator-like liver effects in obese mice
J. Lipid Res., July 1, 1999; 40(7): 1177 - 1184.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. J. Wilkes, A. Bonen, and R. C. Bell
A modified high-fat diet induces insulin resistance in rat skeletal muscle but not adipocytes
Am J Physiol Endocrinol Metab, October 1, 1998; 275(4): E679 - E686.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Valet, D. Grujic, J. Wade, M. Ito, M. C. Zingaretti, V. Soloveva, S. R. Ross, R. A. Graves, S. Cinti, M. Lafontan, et al.
Expression of Human alpha 2-Adrenergic Receptors in Adipose Tissue of beta 3-Adrenergic Receptor-deficient Mice Promotes Diet-induced Obesity
J. Biol. Chem., October 27, 2000; 275(44): 34797 - 34802.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Guerre-Millo, P. Gervois, E. Raspe, L. Madsen, P. Poulain, B. Derudas, J.-M. Herbert, D. A. Winegar, T. M. Willson, J.-C. Fruchart, et al.
Peroxisome Proliferator-activated Receptor alpha Activators Improve Insulin Sensitivity and Reduce Adiposity
J. Biol. Chem., May 26, 2000; 275(22): 16638 - 16642.
[Abstract] [Full Text] [PDF]