Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Samec, S.
Right arrow Articles by Dulloo, A. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Samec, S.
Right arrow Articles by Dulloo, A. G.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 48, Issue 2 436-441, Copyright © 1999 by American Diabetes Association

ARTICLES

Post-starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition: a link with insulin resistance

S Samec, J Seydoux and AG Dulloo
Department of Physiology, Faculty of Medicine, University of Geneva, Switzerland.

UCP2 and UCP3 are two recently cloned genes with high sequence homology to the gene for uncoupling protein (UCP)-1, which regulates thermogenesis in brown adipose tissue. In the context of the current debate about whether UCP2 and UCP3 in the skeletal muscle may also function as mediators of thermogenesis or as regulators of lipids as fuel substrate, we have examined their mRNA expressions in rat gastrocnemius muscle in response to dietary manipulations known to differentially affect thermogenesis during the phase of weight recovery after starvation. Compared with ad libitum-fed control rats, the refeeding of isocaloric amounts of a low-fat (high-carbohydrate) diet resulted in lower energy expenditure and lower mRNA levels of muscle UCP2 and UCP3. This downregulation of UCP homologs was abolished by the refeeding of a high-fat diet, even though energy expenditure was significantly lower during refeeding on the high-fat than on the low-fat diet. Furthermore, major alterations in the fatty acid composition of the refeeding diet in favor of n-6 polyunsaturated or medium-chain fatty acids resulted in significant increases in energy expenditure, but with no significant changes in the expression of skeletal muscle UCP homologs. Regression analysis of gastrocnemius UCP mRNA levels against parameters that included body composition, energy expenditure, and plasma levels of free fatty acids (FFAs), insulin, and glucose as well as the increase in plasma glucose after a glucose load, revealed that only the latter (an index of insulin resistance) could explain the variability in muscle UCP2 and UCP3 mRNA expressions (r = 0.41, P < 0.02; r = 0.45, P < 0.01, respectively). Taken together, these data are at variance with a role for skeletal muscle UCP2 and UCP3 in dietary regulation (or modulation) of thermogenesis. However, they are consistent with the notion that these UCP homologs may function as regulators of lipids as fuel substrate and raise the possibility that high-fat induced upregulation of muscle UCP2 and UCP3 may be more closely linked to insulin resistance than to changes in circulating FFAs.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
X. Wang, J. Axelsson, L. Nordfors, A. R. Qureshi, C. Avesani, P. Barany, M. Schalling, O. Heimburger, B. Lindholm, and P. Stenvinkel
Changes in fat mass after initiation of maintenance dialysis is influenced by the uncoupling protein 2 exon 8 insertion/deletion polymorphism
Nephrol. Dial. Transplant., January 1, 2007; 22(1): 196 - 202.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. A. Pearen, J. G. Ryall, M. A. Maxwell, N. Ohkura, G. S. Lynch, and G. E. O. Muscat
The Orphan Nuclear Receptor, NOR-1, Is a Target of {beta}-Adrenergic Signaling in Skeletal Muscle
Endocrinology, November 1, 2006; 147(11): 5217 - 5227.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
R. R Almon, D. C DuBois, J. Y Jin, and W. J Jusko
Temporal profiling of the transcriptional basis for the development of corticosteroid-induced insulin resistance in rat muscle
J. Endocrinol., January 1, 2005; 184(1): 219 - 232.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. D'Adamo, L. Perego, M. Cardellini, M. A. Marini, S. Frontoni, F. Andreozzi, A. Sciacqua, D. Lauro, P. Sbraccia, M. Federici, et al.
The -866A/A Genotype in the Promoter of the Human Uncoupling Protein 2 Gene Is Associated With Insulin Resistance and Increased Risk of Type 2 Diabetes
Diabetes, July 1, 2004; 53(7): 1905 - 1910.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. R. Commerford, L. Peng, J. J. Dube, and R. M. O'Doherty
In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R218 - R227.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
H. Xiao, D. Massaro, G. D. Massaro, and L. B. Clerch
Expression of Lung Uncoupling Protein-2 mRNA Is Modulated Developmentally and by Caloric Intake
Experimental Biology and Medicine, June 1, 2004; 229(6): 479 - 485.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Crescenzo, S. Samec, V. Antic, F. Rohner-Jeanrenaud, J. Seydoux, J.-P. Montani, and A. G. Dulloo
A Role for Suppressed Thermogenesis Favoring Catch-Up Fat in the Pathophysiology of Catch-Up Growth
Diabetes, May 1, 2003; 52(5): 1090 - 1097.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
D. Cameron-Smith, L. M Burke, D. J Angus, R. J Tunstall, G. R Cox, A. Bonen, J. A Hawley, and M. Hargreaves
A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle
Am. J. Clinical Nutrition, February 1, 2003; 77(2): 313 - 318.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. Chen and B. L. G. Nyomba
Glucose Intolerance and Resistin Expression in Rat Offspring Exposed to Ethanol in Utero: Modulation by Postnatal High-Fat Diet
Endocrinology, February 1, 2003; 144(2): 500 - 508.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
P. Schrauwen and M. Hesselink
UCP2 and UCP3 in muscle controlling body metabolism
J. Exp. Biol., August 1, 2002; 205(15): 2275 - 2285.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
I. Guillet-Deniau, V. Mieulet, S. Le Lay, Y. Achouri, D. Carre, J. Girard, F. Foufelle, and P. Ferre
Sterol Regulatory Element Binding Protein-1c Expression and Action in Rat Muscles: Insulin-Like Effects on the Control of Glycolytic and Lipogenic Enzymes and UCP3 Gene Expression
Diabetes, June 1, 2002; 51(6): 1722 - 1728.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Argyropoulos and M.-E. Harper
Molecular Biology of Thermoregulation: Invited Review: Uncoupling proteins and thermoregulation
J Appl Physiol, May 1, 2002; 92(5): 2187 - 2198.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
V. M Rodriguez, M. P Portillo, C. Pico, M T. Macarulla, and A. Palou
Olive oil feeding up-regulates uncoupling protein genes in rat brown adipose tissue and skeletal muscle
Am. J. Clinical Nutrition, February 1, 2002; 75(2): 213 - 220.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Schrauwen, M. K. C. Hesselink, I. Vaartjes, E. Kornips, W. H. M. Saris, J.-P. Giacobino, and A. Russell
Effect of acute exercise on uncoupling protein 3 is a fat metabolism-mediated effect
Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E11 - E17.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
M. E. YOUNG, S. PATIL, J. YING, C. DEPRE, H. S. AHUJA, G. L. SHIPLEY, S. M. STEPKOWSKI, P. J. A. DAVIES, and H. TAEGTMEYER
Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor {alpha} in the adult rodent heart
FASEB J, March 1, 2001; 15(3): 833 - 845.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
E. A. Boehm, B. E. Jones, G. K. Radda, R. L. Veech, and K. Clarke
Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart
Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H977 - H983.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
Abdul.G. Dulloo and S. Samec
Uncoupling Proteins: Do They Have a Role in Body Weight Regulation?
Physiology, December 1, 2000; 15(6): 313 - 318.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Masaki, H. Yoshimatsu, S. Chiba, and T. Sakata
Impaired response of UCP family to cold exposure in diabetic (db/db) mice
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1305 - R1309.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
X. X. Yu, J. L. Barger, B. B. Boyer, M. D. Brand, G. Pan, and S. H. Adams
Impact of endotoxin on UCP homolog mRNA abundance, thermoregulation, and mitochondrial proton leak kinetics
Am J Physiol Endocrinol Metab, August 1, 2000; 279(2): E433 - E446.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
S. Hidaka, H. Yoshimatsu, T. Kakuma, H. Sakino, S. Kondou, R. Hanada, K. Oka, Y. Teshima, M. Kurokawa, and T. Sakata
Tissue-Specific Expression of the Uncoupling Protein Family in Streptozotocin-Induced Diabetic Rats
Experimental Biology and Medicine, July 1, 2000; 224(3): 172 - 177.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. L. Hildebrandt and P. D. Neufer
Exercise attenuates the fasting-induced transcriptional activation of metabolic genes in skeletal muscle
Am J Physiol Endocrinol Metab, June 1, 2000; 278(6): E1078 - E1086.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. H. Adams
Uncoupling Protein Homologs: Emerging Views of Physiological Function
J. Nutr., April 1, 2000; 130(4): 711 - 714.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
A. V. Medvedev, S. K. Snedden, S. Raimbault, D. Ricquier, and S. Collins
Transcriptional Regulation of the Mouse Uncoupling Protein-2 Gene. DOUBLE E-BOX MOTIF IS REQUIRED FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-gamma -DEPENDENT ACTIVATION
J. Biol. Chem., March 30, 2001; 276(14): 10817 - 10823.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 1999 by the American Diabetes Association.