Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hohmeier, H. E.
Right arrow Articles by Newgard, C. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hohmeier, H. E.
Right arrow Articles by Newgard, C. B.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes, Vol 49, Issue 3 424-430, Copyright © 2000 by American Diabetes Association

ARTICLES

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

HE Hohmeier, H Mulder, G Chen, R Henkel-Rieger, M Prentki and CB Newgard
BetaGene, Inc., Dallas, Texas, USA.

The biochemical mechanisms involved in regulation of insulin secretion are not completely understood. The rat INS-1 cell line has been used to gain insight in this area because it secretes insulin in response to glucose concentrations in the physiological range. However, the magnitude of the response is far less than that seen in freshly isolated rat islets. In the current study, we have stably transfected INS-1 cells with a plasmid containing the human proinsulin gene. After antibiotic selection and clonal expansion, 67% of the resultant clones were found to be poorly responsive to glucose in terms of insulin secretion (< or =2-fold stimulation by 15 mmol/l compared with 3 mmol/l glucose), 17% of the clones were moderately responsive (2- to 5-fold stimulation), and 16% were strongly responsive (5- to 13-fold stimulation). The differences in responsiveness could not be ascribed to differences in insulin content. Detailed analysis of one of the strongly responsive lines (832/13) revealed that its potent response to glucose (average of 10-fold) was stable over 66 population doublings (approximately 7.5 months of tissue culture) with half-maximal stimulation at 6 mmol/l glucose. Furthermore, in the presence of 15 mmol/l glucose, insulin secretion was potentiated significantly by 100 pmol/l isobutylmethylxanthine (320%), 1 mmol/l oleate/palmitate (77%), and 50 nmol/l glucagon-like peptide 1 (60%), whereas carbachol had no effect. Glucose-stimulated insulin secretion was also potentiated by the sulfonylurea tolbutamide (threefold at 3 mmol/l glucose and 50% at 15 mmol/l glucose) and was abolished by diazoxide, which demonstrates the operation of the ATP-sensitive K+ channel (K(ATP)) in 832/13 cells. Moreover, when the K(ATP) channel was bypassed by incubation of cells in depolarizing K+ (35 mmol/l), insulin secretion was more effectively stimulated by glucose in 832/13 cells than in parental INS-1 cells, which demonstrates the presence of a K(ATP) channel-independent pathway of glucose sensing. We conclude that clonal selection of INS-1 cells allows isolation of cell lines that exhibit markedly enhanced and stable responsiveness to glucose and several of its known potentiators. These lines may be attractive new vehicles for studies of beta-cell function.
Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
A. I. Tarasov, T. J. Nicolson, J.-P. Riveline, T. K. Taneja, S. A. Baldwin, J. M. Baldwin, G. Charpentier, J.-F. Gautier, P. Froguel, M. Vaxillaire, et al.
A Rare Mutation in ABCC8/SUR1 Leading to Altered ATP-Sensitive K+ Channel Activity and {beta}-Cell Glucose Sensing Is Associated With Type 2 Diabetes in Adults
Diabetes, June 1, 2008; 57(6): 1595 - 1604.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Chen, G. Saxena, I. N. Mungrue, A. J. Lusis, and A. Shalev
Thioredoxin-Interacting Protein: A Critical Link Between Glucose Toxicity and {beta}-Cell Apoptosis
Diabetes, April 1, 2008; 57(4): 938 - 944.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. Li, X. Yin, E. J. Zmuda, C. C. Wolford, X. Dong, M. F. White, and T. Hai
The Repression of IRS2 Gene by ATF3, a Stress-Inducible Gene, Contributes to Pancreatic {beta}-Cell Apoptosis
Diabetes, March 1, 2008; 57(3): 635 - 644.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. S. Goehring, B. S. Pedroja, S. A. Hinke, L. K. Langeberg, and J. D. Scott
MyRIP Anchors Protein Kinase A to the Exocyst Complex
J. Biol. Chem., November 9, 2007; 282(45): 33155 - 33167.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. W. Joseph, M. L. Odegaard, S. M. Ronnebaum, S. C. Burgess, J. Muehlbauer, A. D. Sherry, and C. B. Newgard
Normal Flux through ATP-Citrate Lyase or Fatty Acid Synthase Is Not Required for Glucose-stimulated Insulin Secretion
J. Biol. Chem., October 26, 2007; 282(43): 31592 - 31600.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Liu, I. Hodish, C. J. Rhodes, and P. Arvan
Proinsulin maturation, misfolding, and proteotoxicity
PNAS, October 2, 2007; 104(40): 15841 - 15846.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Hao, W. S. Head, S. C. Gunawardana, A. H. Hasty, and D. W. Piston
Direct Effect of Cholesterol on Insulin Secretion: A Novel Mechanism for Pancreatic {beta}-Cell Dysfunction
Diabetes, September 1, 2007; 56(9): 2328 - 2338.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. A. Martens, A. Vervoort, M. Van de Casteele, G. Stange, K. Hellemans, H. V. Van Thi, F. Schuit, and D. Pipeleers
Specificity in Beta Cell Expression of L-3-Hydroxyacyl-CoA Dehydrogenase, Short Chain, and Potential Role in Down-regulating Insulin Release
J. Biol. Chem., July 20, 2007; 282(29): 21134 - 21144.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Baroukh, M. A. Ravier, M. K. Loder, E. V. Hill, A. Bounacer, R. Scharfmann, G. A. Rutter, and E. Van Obberghen
MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic beta-Cell Lines
J. Biol. Chem., July 6, 2007; 282(27): 19575 - 19588.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. Jason Collier, P. Zhang, K. B. Pedersen, S. J. Burke, J. W. Haycock, and D. K. Scott
c-Myc and ChREBP regulate glucose-mediated expression of the L-type pyruvate kinase gene in INS-1-derived 832/13 cells
Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E48 - E56.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. E. Gleason, D. Lu, L. A. Witters, C. B. Newgard, and M. J. Birnbaum
The Role of AMPK and mTOR in Nutrient Sensing in Pancreatic beta-Cells
J. Biol. Chem., April 6, 2007; 282(14): 10341 - 10351.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
N. A. Kaniuk, M. Kiraly, H. Bates, M. Vranic, A. Volchuk, and J. H. Brumell
Ubiquitinated-Protein Aggregates Form in Pancreatic {beta}-Cells During Diabetes-Induced Oxidative Stress and Are Regulated by Autophagy
Diabetes, April 1, 2007; 56(4): 930 - 939.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. J. MacDonald
Synergistic Potent Insulin Release by Combinations of Weak Secretagogues in Pancreatic Islets and INS-1 Cells
J. Biol. Chem., March 2, 2007; 282(9): 6043 - 6052.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
O. T. Hardy, H. E. Hohmeier, T. C. Becker, E. Manduchi, N. M. Doliba, R. K. Gupta, P. White, C. J. Stoeckert Jr, F. M. Matschinsky, C. B. Newgard, et al.
Functional Genomics of the {beta}-Cell: Short-Chain 3-Hydroxyacyl-Coenzyme A Dehydrogenase Regulates Insulin Secretion Independent of K+ Currents
Mol. Endocrinol., March 1, 2007; 21(3): 765 - 773.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. B. Pedersen, P. Zhang, C. Doumen, M. Charbonnet, D. Lu, C. B. Newgard, J. W. Haycock, A. J. Lange, and D. K. Scott
The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions
Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E788 - E801.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. L. Pongratz, R. G. Kibbey, G. I. Shulman, and G. W. Cline
Cytosolic and Mitochondrial Malic Enzyme Isoforms Differentially Control Insulin Secretion
J. Biol. Chem., January 5, 2007; 282(1): 200 - 207.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Buteau, A. Shlien, S. Foisy, and D. Accili
Metabolic Diapause in Pancreatic beta-Cells Expressing a Gain-of-function Mutant of the Forkhead Protein Foxo1
J. Biol. Chem., January 5, 2007; 282(1): 287 - 293.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
L. O'Driscoll, P. Gammell, E. McKiernan, E. Ryan, P. B. Jeppesen, S. Rani, and M. Clynes
Phenotypic and global gene expression profile changes between low passage and high passage MIN-6 cells
J. Endocrinol., December 1, 2006; 191(3): 665 - 676.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. Van Lommel, K. Janssens, R. Quintens, K. Tsukamoto, D. Vander Mierde, K. Lemaire, C. Denef, J.-C. Jonas, G. Martens, D. Pipeleers, et al.
Probe-Independent and Direct Quantification of Insulin mRNA and Growth Hormone mRNA in Enriched Cell Preparations
Diabetes, December 1, 2006; 55(12): 3214 - 3220.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. W. Joseph, M. V. Jensen, O. Ilkayeva, F. Palmieri, C. Alarcon, C. J. Rhodes, and C. B. Newgard
The Mitochondrial Citrate/Isocitrate Carrier Plays a Regulatory Role in Glucose-stimulated Insulin Secretion
J. Biol. Chem., November 24, 2006; 281(47): 35624 - 35632.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Gan, L. Zhao, L. Yang, P. Huang, F. Zhao, W. Li, and Y. Liu
RNA Editing by ADAR2 Is Metabolically Regulated in Pancreatic Islets and beta-Cells
J. Biol. Chem., November 3, 2006; 281(44): 33386 - 33394.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. M. Ronnebaum, O. Ilkayeva, S. C. Burgess, J. W. Joseph, D. Lu, R. D. Stevens, T. C. Becker, A. D. Sherry, C. B. Newgard, and M. V. Jensen
A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase Regulates Glucose-stimulated Insulin Secretion
J. Biol. Chem., October 13, 2006; 281(41): 30593 - 30602.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. V. Jensen, J. W. Joseph, O. Ilkayeva, S. Burgess, D. Lu, S. M. Ronnebaum, M. Odegaard, T. C. Becker, A. D. Sherry, and C. B. Newgard
Compensatory Responses to Pyruvate Carboxylase Suppression in Islet beta-Cells: PRESERVATION OF GLUCOSE-STIMULATED INSULIN SECRETION
J. Biol. Chem., August 4, 2006; 281(31): 22342 - 22351.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. C. Raum, K. Gerrish, I. Artner, E. Henderson, M. Guo, L. Sussel, J. C. Schisler, C. B. Newgard, and R. Stein
FoxA2, Nkx2.2, and PDX-1 Regulate Islet {beta}-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs -8118 and -7750 Upstream from the Transcription Start Site
Mol. Cell. Biol., August 1, 2006; 26(15): 5735 - 5743.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C.-W. Lin, Y.-W. Lin, F.-F. Yan, J. Casey, M. Kochhar, E. B. Pratt, and S.-L. Shyng
Kir6.2 Mutations Associated With Neonatal Diabetes Reduce Expression of ATP-Sensitive K+ channels: Implications in Disease Mechanism and Sulfonylurea Therapy
Diabetes, June 1, 2006; 55(6): 1738 - 1746.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. V. Li, B. Chang, M. Imamura, N. Poungvarin, and L. Chan
Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module.
Diabetes, May 1, 2006; 55(5): 1179 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Buteau, M. L. Spatz, and D. Accili
Transcription Factor FoxO1 Mediates Glucagon-Like Peptide-1 Effects on Pancreatic {beta}-Cell Mass.
Diabetes, May 1, 2006; 55(5): 1190 - 1196.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. J. Collier, P. T. Fueger, H. E. Hohmeier, and C. B. Newgard
Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and {beta}-Cell Lines.
Diabetes, May 1, 2006; 55(5): 1398 - 1406.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R. Lara-Lemus, M. Liu, M. D. Turner, P. Scherer, G. Stenbeck, P. Iyengar, and P. Arvan
Lumenal protein sorting to the constitutive secretory pathway of a regulated secretory cell
J. Cell Sci., May 1, 2006; 119(9): 1833 - 1842.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
N. Wierup, M. Bjorkqvist, M. J. Kuhar, H. Mulder, and F. Sundler
CART Regulates Islet Hormone Secretion and Is Expressed in the {beta}-Cells of Type 2 Diabetic Rats
Diabetes, February 1, 2006; 55(2): 305 - 311.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
F.-F. Yan, C.-W. Lin, E. A. Cartier, and S.-L. Shyng
Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels
Am J Physiol Cell Physiol, November 1, 2005; 289(5): C1351 - C1359.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C.-W. Lin, F. Yan, S. Shimamura, S. Barg, and S.-L. Shyng
Membrane Phosphoinositides Control Insulin Secretion Through Their Effects on ATP-Sensitive K+ Channel Activity
Diabetes, October 1, 2005; 54(10): 2852 - 2858.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. E. Kimple, A. B. Nixon, P. Kelly, C. L. Bailey, K. H. Young, T. A. Fields, and P. J. Casey
A Role for Gz in Pancreatic Islet {beta}-Cell Biology
J. Biol. Chem., September 9, 2005; 280(36): 31708 - 31713.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
L. Marzban, G. Trigo-Gonzalez, and C. B. Verchere
Processing of Pro-Islet Amyloid Polypeptide in the Constitutive and Regulated Secretory Pathways of {beta} Cells
Mol. Endocrinol., August 1, 2005; 19(8): 2154 - 2163.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. C. Lawrence, K. McGlynn, B.-H. Park, and M. H. Cobb
ERK1/2-dependent Activation of Transcription Factors Required for Acute and Chronic Effects of Glucose on the Insulin Gene Promoter
J. Biol. Chem., July 22, 2005; 280(29): 26751 - 26759.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. N. Samli, M. J. McGuire, C. B. Newgard, S. A. Johnston, and K. C. Brown
Peptide-Mediated Targeting of the Islets of Langerhans
Diabetes, July 1, 2005; 54(7): 2103 - 2108.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
L B Hays, B Wicksteed, Y Wang, J F McCuaig, L H Philipson, J M Edwardson, and C J Rhodes
Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic {beta}-cells
J. Endocrinol., April 1, 2005; 185(1): 57 - 67.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. Bjorkqvist, M. Fex, E. Renstrom, N. Wierup, A. Petersen, J. Gil, K. Bacos, N. Popovic, J.-Y. Li, F. Sundler, et al.
The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient {beta}-cell mass and exocytosis
Hum. Mol. Genet., March 1, 2005; 14(5): 565 - 574.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. Herrero, B. Rubi, D. Sebastian, D. Serra, G. Asins, P. Maechler, M. Prentki, and F. G. Hegardt
Alteration of the Malonyl-CoA/Carnitine Palmitoyltransferase I Interaction in the {beta}-Cell Impairs Glucose-Induced Insulin Secretion
Diabetes, February 1, 2005; 54(2): 462 - 471.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. G. Straub and G. W. G. Sharp
Massive Augmentation of Stimulated Insulin Secretion Induced by Fatty Acid-Free BSA in Rat Pancreatic Islets
Diabetes, December 1, 2004; 53(12): 3152 - 3158.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L.-Z. Cao, D.-Q. Tang, M. E. Horb, S.-W. Li, and L.-J. Yang
High Glucose Is Necessary for Complete Maturation of Pdx1-VP16-Expressing Hepatic Cells into Functional Insulin-Producing Cells
Diabetes, December 1, 2004; 53(12): 3168 - 3178.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. W. Cline, R. L. LePine, K. K. Papas, R. G. Kibbey, and G. I. Shulman
13C NMR Isotopomer Analysis of Anaplerotic Pathways in INS-1 Cells
J. Biol. Chem., October 22, 2004; 279(43): 44370 - 44375.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Yang, U. Fransson, L. Fagerhus, L. Stenson Holst, H. E. Hohmeier, E. Renstrom, and H. Mulder
Enhanced cAMP Protein Kinase A Signaling Determines Improved Insulin Secretion in a Clonal Insulin-Producing {beta}-Cell Line (INS-1 832/13)
Mol. Endocrinol., September 1, 2004; 18(9): 2312 - 2320.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. R. Bain, J. C. Schisler, K. Takeuchi, C. B. Newgard, and T. C. Becker
An Adenovirus Vector for Efficient RNA Interference-Mediated Suppression of Target Genes in Insulinoma Cells and Pancreatic Islets of Langerhans
Diabetes, September 1, 2004; 53(9): 2190 - 2194.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
M. G. Hartman, D. Lu, M.-L. Kim, G. J. Kociba, T. Shukri, J. Buteau, X. Wang, W. L. Frankel, D. Guttridge, M. Prentki, et al.
Role for Activating Transcription Factor 3 in Stress-Induced {beta}-Cell Apoptosis
Mol. Cell. Biol., July 1, 2004; 24(13): 5721 - 5732.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D.-Q. Tang, L.-Z. Cao, B. R. Burkhardt, C.-Q. Xia, S. A. Litherland, M. A. Atkinson, and L.-J. Yang
In Vivo and In Vitro Characterization of Insulin-Producing Cells Obtained From Murine Bone Marrow
Diabetes, July 1, 2004; 53(7): 1721 - 1732.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Boucher, D. Lu, S. C. Burgess, S. Telemaque-Potts, M. V. Jensen, H. Mulder, M.-Y. Wang, R. H. Unger, A. D. Sherry, and C. B. Newgard
Biochemical Mechanism of Lipid-induced Impairment of Glucose-stimulated Insulin Secretion and Reversal with a Malate Analogue
J. Biol. Chem., June 25, 2004; 279(26): 27263 - 27271.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Palanivel, R. Veluthakal, and A. Kowluru
Regulation by glucose and calcium of the carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting INS-1 cells
Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E1032 - E1041.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Roduit, C. Nolan, C. Alarcon, P. Moore, A. Barbeau, V. Delghingaro-Augusto, E. Przybykowski, J. Morin, F. Masse, B. Massie, et al.
A Role for the Malonyl-CoA/Long-Chain Acyl-CoA Pathway of Lipid Signaling in the Regulation of Insulin Secretion in Response to Both Fuel and Nonfuel Stimuli
Diabetes, April 1, 2004; 53(4): 1007 - 1019.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Crane and L. Aguilar-Bryan
Assembly, Maturation, and Turnover of KATP Channel Subunits
J. Biol. Chem., March 5, 2004; 279(10): 9080 - 9090.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
N. Wierup, S. Yang, R. J. McEvilly, H. Mulder, and F. Sundler
Ghrelin Is Expressed in a Novel Endocrine Cell Type in Developing Rat Islets and Inhibits Insulin Secretion from INS-1 (832/13) Cells
J. Histochem. Cytochem., March 1, 2004; 52(3): 301 - 310.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
N. Wierup, M. Kuhar, B.O. Nilsson, H. Mulder, E. Ekblad, and F. Sundler
Cocaine- and Amphetamine-regulated Transcript (CART) Is Expressed in Several Islet Cell Types During Rat Development
J. Histochem. Cytochem., February 1, 2004; 52(2): 169 - 177.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Merglen, S. Theander, B. Rubi, G. Chaffard, C. B. Wollheim, and P. Maechler
Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells
Endocrinology, February 1, 2004; 145(2): 667 - 678.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. Ramanadham, H. Song, S. Bao, F.-F. Hsu, S. Zhang, Z. Ma, C. Jin, and J. Turk
Islet Complex Lipids: Involvement in the Actions of Group VIA Calcium-Independent Phospholipase A2 in {beta}-Cells
Diabetes, February 1, 2004; 53(90001): S179 - 185.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
J. A. Ehses, V. R. Casilla, T. Doty, J. A. Pospisilik, K. D. Winter, H.-U. Demuth, R. A. Pederson, and C. H. S. McIntosh
Glucose-Dependent Insulinotropic Polypeptide Promotes {beta}-(INS-1) Cell Survival via Cyclic Adenosine Monophosphate-Mediated Caspase-3 Inhibition and Regulation of p38 Mitogen-Activated Protein Kinase
Endocrinology, October 1, 2003; 144(10): 4433 - 4445.
[Abstract] [Full Text] [PDF]