Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schuit, F. C.
Right arrow Articles by Pipeleers, D. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schuit, F. C.
Right arrow Articles by Pipeleers, D. G.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Diabetes 50:1-11, 2001
© 2001 by the American Diabetes Association, Inc.

Glucose Sensing in Pancreatic ß-Cells

A Model for the Study of Other Glucose-Regulated Cells in Gut, Pancreas, and Hypothalamus

Frans C. Schuit, Peter Huypens, Harry Heimberg, and Daniel G. Pipeleers

From the Diabetes Research Center, Faculty of Medicine, Vrije Universiteit Brussel, Brussels, Belgium.

Address correspondence and reprint requests to Frans C. Schuit, MD, PhD, Diabetes Research Center, Vrije Universiteit Brussel. E-mail: fschuit{at}minf.vub.ac.be .

Nutrient homeostasis is known to be regulated by pancreatic islet tissue. The function of islet ß-cells is controlled by a glucose sensor that operates at physiological glucose concentrations and acts in synergy with signals that integrate messages originating from hypothalamic neurons and endocrine cells in gut and pancreas. Evidence exists that the extrapancreatic cells producing and secreting these (neuro)endocrine signals also exhibit a glucose sensor and an ability to integrate nutrient and (neuro)hormonal messages. Similarities in these cellular and molecular pathways provide a basis for a network of coordinated functions between distant cell groups, which is necessary for an appropriate control of nutrient homeostasis. The glucose sensor seems to be a fundamental component of these control mechanisms. Its molecular characterization is most advanced in pancreatic ß-cells, with important roles for glucokinase and mitochondrial oxidative fluxes in the regulation of ATP-sensitive K+ channels. Other glucose-sensitive cells in the endocrine pancreas, hypothalamus, and gut were found to share some of these molecular characteristics. We propose that similar metabolic signaling pathways influence the function of pancreatic {alpha}-cells, hypothalamic neurons, and gastrointestinal endocrine and neural cells.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
M. Garcia-Fernandez, P. Ortega-Saenz, A. Castellano, and J. Lopez-Barneo
Mechanisms of Low-Glucose Sensitivity in Carotid Body Glomus Cells
Diabetes, December 1, 2007; 56(12): 2893 - 2900.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Polakof, J. M. Miguez, and J. L. Soengas
In vitro evidences for glucosensing capacity and mechanisms in hypothalamus, hindbrain, and Brockmann bodies of rainbow trout
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1410 - R1420.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
N. Marty, M. Dallaporta, and B. Thorens
Brain Glucose Sensing, Counterregulation, and Energy Homeostasis
Physiology, August 1, 2007; 22(4): 241 - 251.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Fukaya, A. Mizuno, H. Arai, K. Muto, T. Uebanso, K. Matsuo, H. Yamamoto, Y. Taketani, T. Doi, and E. Takeda
Mechanism of rapid-phase insulin response to elevation of portal glucose concentration
Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E515 - E522.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. Johnson, R. M. Shepherd, D. Gill, T. Gorman, D. M. Smith, and M. J. Dunne
Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator
Diabetes, June 1, 2007; 56(6): 1694 - 1702.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. F. Pino, K.-A. Kim, K. D. Shelton, J. Lindner, S. Odili, C. Li, H. W. Collins, M. Shiota, F. M. Matschinsky, and M. A. Magnuson
Glucokinase Thermolability and Hepatic Regulatory Protein Binding Are Essential Factors for Predicting the Blood Glucose Phenotype of Missense Mutations
J. Biol. Chem., May 4, 2007; 282(18): 13906 - 13916.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Polakof, J. M. Miguez, T. W. Moon, and J. L. Soengas
Evidence for the presence of a glucosensor in hypothalamus, hindbrain, and Brockmann bodies of rainbow trout
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1657 - R1666.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
F. Cai, A. V Gyulkhandanyan, M. B Wheeler, and D. D Belsham
Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin
J. Endocrinol., March 1, 2007; 192(3): 605 - 614.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Gromada, I. Franklin, and C. B. Wollheim
{alpha}-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains
Endocr. Rev., February 1, 2007; 28(1): 84 - 116.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Q. Huang, S. Bu, Y. Yu, Z. Guo, G. Ghatnekar, M. Bu, L. Yang, B. Lu, Z. Feng, S. Liu, et al.
Diazoxide Prevents Diabetes through Inhibiting Pancreatic {beta}-Cells from Apoptosis via Bcl-2/Bax Rate and p38-{beta} Mitogen-Activated Protein Kinase
Endocrinology, January 1, 2007; 148(1): 81 - 91.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. L. Freeman, D. Bohan, N. Darcel, and H. E. Raybould
Luminal glucose sensing in the rat intestine has characteristics of a sodium-glucose cotransporter
Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G439 - G445.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. Zelent, M. L. Golson, B. Koeberlein, R. Quintens, L. van Lommel, C. Buettger, H. Weik-Collins, R. Taub, J. Grimsby, F. Schuit, et al.
A glucose sensor role for glucokinase in anterior pituitary cells.
Diabetes, July 1, 2006; 55(7): 1923 - 1929.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. Leloup, C. Magnan, A. Benani, E. Bonnet, T. Alquier, G. Offer, A. Carriere, A. Periquet, Y. Fernandez, A. Ktorza, et al.
Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing.
Diabetes, July 1, 2006; 55(7): 2084 - 2090.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. V. Sagen, S. Odili, L. Bjorkhaug, D. Zelent, C. Buettger, J. Kwagh, C. Stanley, K. Dahl-Jorgensen, C. de Beaufort, G. I. Bell, et al.
From Clinicogenetic Studies of Maturity-Onset Diabetes of the Young to Unraveling Complex Mechanisms of Glucokinase Regulation
Diabetes, June 1, 2006; 55(6): 1713 - 1722.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
O. Chan, W. Zhu, Y. Ding, R. J. McCrimmon, and R. S. Sherwin
Blockade of GABAA Receptors in the Ventromedial Hypothalamus Further Stimulates Glucagon and Sympathoadrenal but Not the Hypothalamo-Pituitary-Adrenal Response to Hypoglycemia.
Diabetes, April 1, 2006; 55(4): 1080 - 1087.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. R. Martin, C. S. Ritter, E. Slatopolsky, and A. J. Brown
Acute regulation of parathyroid hormone by dietary phosphate
Am J Physiol Endocrinol Metab, October 1, 2005; 289(4): E729 - E734.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. M. Efanov, D. G. Barrett, M. B. Brenner, S. L. Briggs, A. Delaunois, J. D. Durbin, U. Giese, H. Guo, M. Radloff, G. S. Gil, et al.
A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function
Endocrinology, September 1, 2005; 146(9): 3696 - 3701.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
S. Kooptiwut, M. Kebede, S. Zraika, S. Visinoni, K. Aston-Mourney, J. Favaloro, C. Tikellis, M. C Thomas, J. M Forbes, M. E Cooper, et al.
High glucose-induced impairment in insulin secretion is associated with reduction in islet glucokinase in a mouse model of susceptibility to islet dysfunction
J. Mol. Endocrinol., August 1, 2005; 35(1): 39 - 48.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
O. Gimenez-Palop, G. Gimenez-Perez, D. Mauricio, E. Berlanga, N. Potau, C. Vilardell, J. Arroyo, J.-M. Gonzalez-Clemente, and A. Caixas
Circulating ghrelin in thyroid dysfunction is related to insulin resistance and not to hunger, food intake or anthropometric changes
Eur. J. Endocrinol., July 1, 2005; 153(1): 73 - 79.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Ivarsson, R. Quintens, S. Dejonghe, K. Tsukamoto, P. in 't Veld, E. Renstrom, and F. C. Schuit
Redox Control of Exocytosis: Regulatory Role of NADPH, Thioredoxin, and Glutaredoxin
Diabetes, July 1, 2005; 54(7): 2132 - 2142.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. Chan, K. Inouye, E. M. Akirav, E. Park, M. C. Riddell, S. G. Matthews, and M. Vranic
Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R235 - R246.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. A. Ravier and G. A. Rutter
Glucose or Insulin, but not Zinc Ions, Inhibit Glucagon Secretion From Mouse Pancreatic {alpha}-Cells
Diabetes, June 1, 2005; 54(6): 1789 - 1797.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. A. Ravier, M. Guldenagel, A. Charollais, A. Gjinovci, D. Caille, G. Sohl, C. B. Wollheim, K. Willecke, J.-C. Henquin, and P. Meda
Loss of Connexin36 Channels Alters {beta}-Cell Coupling, Islet Synchronization of Glucose-Induced Ca2+ and Insulin Oscillations, and Basal Insulin Release
Diabetes, June 1, 2005; 54(6): 1798 - 1807.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. L. Gloyn, S. Odili, D. Zelent, C. Buettger, H. A. J. Castleden, A. M. Steele, A. Stride, C. Shiota, M. A. Magnuson, R. Lorini, et al.
Insights into the Structure and Regulation of Glucokinase from a Novel Mutation (V62M), Which Causes Maturity-onset Diabetes of the Young
J. Biol. Chem., April 8, 2005; 280(14): 14105 - 14113.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
X. Fioramonti, A. Lorsignol, A. Taupignon, and L. Penicaud
A New ATP-Sensitive K+ Channel-Independent Mechanism Is Involved in Glucose-Excited Neurons of Mouse Arcuate Nucleus
Diabetes, November 1, 2004; 53(11): 2767 - 2775.
[Abstract] [Full Text] [PDF]

Home page
 J Biomol ScreenHome page
P. Arkhammar, P. Wahl, B. Gerlach, T. Fremming, and J. B. Hansen
Establishment and Application of in Vitro Membrane Potential Assays in Cell Lines with Endogenous or Recombinant Expression of ATP-Sensitive Potassium Channels (Kir6.2/SUR1) Using a Fluorescent Probe Kit
J Biomol Screen, August 1, 2004; 9(5): 382 - 390.
[Abstract] [PDF]

Home page
 EndocrinologyHome page
L. Wang, C. Coffinier, M. K. Thomas, L. Gresh, G. Eddu, T. Manor, L. L. Levitsky, M. Yaniv, and D. B. Rhoads
Selective Deletion of the Hnf1{beta} (MODY5) Gene in {beta}-Cells Leads to Altered Gene Expression and Defective Insulin Release
Endocrinology, August 1, 2004; 145(8): 3941 - 3949.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. A. Hinke, K. Hellemans, and F. C. Schuit
Plasticity of the {beta} cell insulin secretory competence: preparing the pancreatic {beta} cell for the next meal
J. Physiol., July 15, 2004; 558(2): 369 - 380.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
K. J. Brocklehurst, V. A. Payne, R. A. Davies, D. Carroll, H. L. Vertigan, H. J. Wightman, S. Aiston, I. D. Waddell, B. Leighton, M. P. Coghlan, et al.
Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators
Diabetes, March 1, 2004; 53(3): 535 - 541.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
L. Kang, V. H. Routh, E. V. Kuzhikandathil, L. D. Gaspers, and B. E. Levin
Physiological and Molecular Characteristics of Rat Hypothalamic Ventromedial Nucleus Glucosensing Neurons
Diabetes, March 1, 2004; 53(3): 549 - 559.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
H.-i. Kim and Y.-h. Ahn
Role of Peroxisome Proliferator-Activated Receptor-{gamma} in the Glucose-Sensing Apparatus of Liver and {beta}-Cells
Diabetes, February 1, 2004; 53(90001): S60 - 65.
[Abstract] [Full Text]

Home page
 DiabetesHome page
X.-J. Yang, L.-M. Kow, D. W. Pfaff, and C. V. Mobbs
Metabolic Pathways That Mediate Inhibition of Hypothalamic Neurons by Glucose
Diabetes, January 1, 2004; 53(1): 67 - 73.
[Abstract] [Full Text] [PDF]

Home page
 Plant CellHome page
G. N. Harrington and D. R. Bush
The Bifunctional Role of Hexokinase in Metabolism and Glucose Signaling
PLANT CELL, November 1, 2003; 15(11): 2493 - 2496.
[Full Text] [PDF]

Home page
 Mol. Interv.Home page
H. Al-Hasani, M. H. Tschop, and S. W. Cushman
Two Birds with One Stone: Novel Glucokinase Activator Stimulates Glucose-Induced Pancreatic Insulin Secretion and Augments Hepatic Glucose Metabolism
Mol. Interv., October 1, 2003; 3(7): 367 - 370.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Le Gurun, D. Martin, A. Formenton, P. Maechler, D. Caille, G. Waeber, P. Meda, and J.-A. Haefliger
Connexin-36 Contributes to Control Function of Insulin-producing Cells
J. Biol. Chem., September 26, 2003; 278(39): 37690 - 37697.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. Zhou, D. S. Roane, X. Xi, I. Bogacka, B. Li, D. H. Ryan, and R. J. Martin
Short-Term Food Restriction and Refeeding Alter Expression of Genes Likely Involved in Brain Glucosensing
Experimental Biology and Medicine, September 1, 2003; 228(8): 943 - 950.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. A. Magnuson, P. She, and M. Shiota
Gene-altered Mice and Metabolic Flux Control
J. Biol. Chem., August 29, 2003; 278(35): 32485 - 32488.
[Full Text] [PDF]

Home page
 DiabetesHome page
J. C. Koster, M. S. Remedi, H. Qiu, C. G. Nichols, and P. W. Hruz
HIV Protease Inhibitors Acutely Impair Glucose-Stimulated Insulin Release
Diabetes, July 1, 2003; 52(7): 1695 - 1700.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
F. M. Gribble, L. Williams, A. K. Simpson, and F. Reimann
A Novel Glucose-Sensing Mechanism Contributing to Glucagon-Like Peptide-1 Secretion From the GLUTag Cell Line
Diabetes, May 1, 2003; 52(5): 1147 - 1154.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
Y. Anini and P. L. Brubaker
Role of Leptin in the Regulation of Glucagon-Like Peptide-1 Secretion
Diabetes, February 1, 2003; 52(2): 252 - 259.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. M. Moates, S. Nanda, M. A. Cissell, M.-J. Tsai, and R. Stein
BETA2 Activates Transcription From the Upstream Glucokinase Gene Promoter in Islet {beta}-Cells and Gut Endocrine Cells
Diabetes, February 1, 2003; 52(2): 403 - 408.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
F. Reimann and F. M. Gribble
Glucose-Sensing in Glucagon-Like Peptide-1-Secreting Cells
Diabetes, September 1, 2002; 51(9): 2757 - 2763.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Bertrand, N. Ishiyama, M. Nenquin, M. A. Ravier, and J.-C. Henquin
The Elevation of Glutamate Content and the Amplification of Insulin Secretion in Glucose-stimulated Pancreatic Islets Are Not Causally Related
J. Biol. Chem., August 30, 2002; 277(36): 32883 - 32891.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Wang, B. R. Gauthier, K. A. Hagenfeldt-Johansson, M. Iezzi, and C. B. Wollheim
Foxa2 (HNF3beta ) Controls Multiple Genes Implicated in Metabolism-Secretion Coupling of Glucose-induced Insulin Release
J. Biol. Chem., May 10, 2002; 277(20): 17564 - 17570.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. A. Antinozzi, H. Ishihara, C. B. Newgard, and C. B. Wollheim
Mitochondrial Metabolism Sets the Maximal Limit of Fuel-stimulated Insulin Secretion in a Model Pancreatic Beta Cell. A SURVEY OF FOUR FUEL SECRETAGOGUES
J. Biol. Chem., March 29, 2002; 277(14): 11746 - 11755.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
H.-i. Kim, J.-Y. Cha, S.-Y. Kim, J.-w. Kim, K. J. Roh, J.-K. Seong, N. T. Lee, K.-Y. Choi, K.-S. Kim, and Y.-h. Ahn
Peroxisomal Proliferator-Activated Receptor-{gamma} Upregulates Glucokinase Gene Expression in {beta}-Cells
Diabetes, March 1, 2002; 51(3): 676 - 685.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
A. L. Kirchgessner
Orexins in the Brain-Gut Axis
Endocr. Rev., February 1, 2002; 23(1): 1 - 15.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
C. B. Wollheim and P. Maechler
{beta}-Cell Mitochondria and Insulin Secretion: Messenger Role of Nucleotides and Metabolites
Diabetes, February 1, 2002; 51(90001): S37 - 42.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Kashima, T. Miki, T. Shibasaki, N. Ozaki, M. Miyazaki, H. Yano, and S. Seino
Critical Role of cAMP-GEFII{middle dot}Rim2 Complex in Incretin-potentiated Insulin Secretion
J. Biol. Chem., November 30, 2001; 276(49): 46046 - 46053.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
K. K. PAPAS, C. K. COLTON, J. S. GOUNARIDES, E. S. ROOS, M. A. C. JAREMA, M. J. SHAPIRO, L. L. CHENG, G. W. CLINE, G. I. SHULMAN, H. WU, et al.
NMR Spectroscopy in {beta} Cell Engineering and Islet Transplantation
Ann. N.Y. Acad. Sci., November 1, 2001; 944(1): 96 - 119.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. Trumper, K. Trumper, H. Trusheim, R. Arnold, B. Goke, and D. Horsch
Glucose-Dependent Insulinotropic Polypeptide Is a Growth Factor for {beta} (INS-1) Cells by Pleiotropic Signaling
Mol. Endocrinol., September 1, 2001; 15(9): 1559 - 1570.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. N. Faradji, E. Havari, Q. Chen, J. Gray, K. Tornheim, B. E. Corkey, R. C. Mulligan, and M. A. Lipes
Glucose-induced Toxicity in Insulin-producing Pituitary Cells That Coexpress GLUT2 and Glucokinase. IMPLICATIONS FOR METABOLIC ENGINEERING
J. Biol. Chem., September 21, 2001; 276(39): 36695 - 36702.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Rubi, H. Ishihara, F. G. Hegardt, C. B. Wollheim, and P. Maechler
GAD65-mediated Glutamate Decarboxylation Reduces Glucose-stimulated Insulin Secretion in Pancreatic Beta Cells
J. Biol. Chem., September 21, 2001; 276(39): 36391 - 36396.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2001 by the American Diabetes Association.