|
 |
|
|||||||
|
|||||||||
© 2001 by the American Diabetes Association, Inc.
Reduced Insulinotropic Effect of Gastric Inhibitory Polypeptide in First-Degree Relatives of Patients With Type 2 Diabetes
1 Medizinische Klinik, Ruhr-Universität Bochum, Knappschafts-Krankenhaus, Bochum (Langendreer), Germany
2 Medizinische Klinik 1, Ruhr-Universität Bochum, St. Josef-Hospital, Bochum, Germany
3 Department of Medical Physiology, Panum Institute, University of Copenhagen, Copenhagen, Denmark
4 Diabeteszentrum Bad Lauterberg, Bad Lauterberg im Harz, Germany
In patients with type 2 diabetes, gastric inhibitory polypeptide (GIP) has lost much of its insulinotropic activity. Whether this is similar in first-degree relatives of patients with type 2 diabetes is unknown. A total of 21 first-degree relatives, 10 patients with type 2 diabetes, and 10 control subjects (normal oral glucose tolerance) were examined. During a hyperglycemic "clamp" (140 mg/dl for 120 min), synthetic human GIP (2 pmol · kg-1 · min-1) was infused intravenously (30–90 min). With exogenous GIP, patients with type 2 diabetes responded with a lower increment (
) in insulin (P = 0.0003) and C-peptide concentrations (P < 0.0001) than control subjects. The GIP effects in first-degree relatives were diminished compared with control subjects ( insulin: P = 0.04; C-peptide: P = 0.016) but significantly higher than in patients with type 2 diabetes (P 
0.05). The responses over the time course were below the 95% CI derived from control subjects in 7 (insulin) and 11 (C-peptide) of 21 first-degree relatives of patients with type 2 diabetes. In conclusion, a reduced insulinotropic activity of GIP is typical for a substantial subgroup of normoglycemic first-degree relatives of patients with type 2 diabetes, pointing to an early, possibly genetic defect.
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Vollmer, J. J. Holst, B. Baller, M. Ellrichmann, M. A. Nauck, W. E. Schmidt, and J. J. Meier Predictors of Incretin Concentrations in Subjects With Normal, Impaired, and Diabetic Glucose Tolerance Diabetes, March 1, 2008; 57(3): 678 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Meier, J. J. Holst, W. E. Schmidt, and M. A. Nauck Reduction of hepatic insulin clearance after oral glucose ingestion is not mediated by glucagon-like peptide 1 or gastric inhibitory polypeptide in humans Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E849 - E856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. K. Knop, T. Vilsboll, P. V. Hojberg, S. Larsen, S. Madsbad, A. Volund, J. J. Holst, and T. Krarup Reduced Incretin Effect in Type 2 Diabetes: Cause or Consequence of the Diabetic State? Diabetes, August 1, 2007; 56(8): 1951 - 1959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhou, M. F. A. Livak, M. Bernier, D. C. Muller, O. D. Carlson, D. Elahi, S. Maudsley, and J. M. Egan Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets Am J Physiol Endocrinol Metab, August 1, 2007; 293(2): E538 - E547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R K. Campbell Rationale for Dipeptidyl Peptidase 4 Inhibitors: A New Class of Oral Agents for the Treatment of Type 2 Diabetes Mellitus Ann. Pharmacother., January 1, 2007; 41(1): 51 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Moghaddam, J. A. Vogt, and T. M. S. Wolever The Effects of Fat and Protein on Glycemic Responses in Nondiabetic Humans Vary with Waist Circumference, Fasting Plasma Insulin, and Dietary Fiber Intake J. Nutr., October 1, 2006; 136(10): 2506 - 2511. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Pereira, E. D. Parker, and A. R. Folsom Coffee consumption and risk of type 2 diabetes mellitus: an 11-year prospective study of 28 812 postmenopausal women. Arch Intern Med, June 26, 2006; 166(12): 1311 - 1316. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Abdul-Ghani, D. Tripathy, and R. A. DeFronzo Contributions of {beta}-Cell Dysfunction and Insulin Resistance to the Pathogenesis of Impaired Glucose Tolerance and Impaired Fasting Glucose Diabetes Care, May 1, 2006; 29(5): 1130 - 1139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mari, A. Gastaldelli, A. Natali, T. Ostergard, O. Schmitz, and E. Ferrannini Characterization of {beta}-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests Am J Physiol Endocrinol Metab, March 1, 2005; 288(3): E541 - E546. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Nauck, B. Baller, and J. J. Meier Gastric Inhibitory Polypeptide and Glucagon-Like Peptide-1 in the Pathogenesis of Type 2 Diabetes Diabetes, December 1, 2004; 53(suppl_3): S190 - S196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Meier, B. Gallwitz, B. Kask, C. F. Deacon, J. J. Holst, W. E. Schmidt, and M. A. Nauck Stimulation of Insulin Secretion by Intravenous Bolus Injection and Continuous Infusion of Gastric Inhibitory Polypeptide in Patients With Type 2 Diabetes and Healthy Control Subjects Diabetes, December 1, 2004; 53(suppl_3): S220 - S224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. T. Bloomgarden Gut-Derived Incretin Hormones and New Therapeutic Approaches Diabetes Care, October 1, 2004; 27(10): 2554 - 2559. [Full Text] [PDF]
|
|
|
|
|
|
N. N. Rudovich, H. J. Rochlitz, and A. F.H. Pfeiffer Reduced Hepatic Insulin Extraction in Response to Gastric Inhibitory Polypeptide Compensates for Reduced Insulin Secretion in Normal-Weight and Normal Glucose Tolerant First-Degree Relatives of Type 2 Diabetic Patients Diabetes, September 1, 2004; 53(9): 2359 - 2365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Holst and J. Gromada Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans Am J Physiol Endocrinol Metab, August 1, 2004; 287(2): E199 - E206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Meier, O. Goetze, J. Anstipp, D. Hagemann, J. J. Holst, W. E. Schmidt, B. Gallwitz, and M. A. Nauck Gastric inhibitory polypeptide does not inhibit gastric emptying in humans Am J Physiol Endocrinol Metab, April 1, 2004; 286(4): E621 - E625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tuomilehto, G. Hu, S. Bidel, J. Lindstrom, and P. Jousilahti Coffee Consumption and Risk of Type 2 Diabetes Mellitus Among Middle-aged Finnish Men and Women JAMA, March 10, 2004; 291(10): 1213 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Meier, M. A. Nauck, D. Kranz, J. J. Holst, C. F. Deacon, D. Gaeckler, W. E. Schmidt, and B. Gallwitz Secretion, Degradation, and Elimination of Glucagon-Like Peptide 1 and Gastric Inhibitory Polypeptide in Patients with Chronic Renal Insufficiency and Healthy Control Subjects Diabetes, March 1, 2004; 53(3): 654 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Drucker Enhancing Incretin Action for the Treatment of Type 2 Diabetes Diabetes Care, October 1, 2003; 26(10): 2929 - 2940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Meier, B. Gallwitz, S. Salmen, O. Goetze, J. J. Holst, W. E. Schmidt, and M. A. Nauck Normalization of Glucose Concentrations and Deceleration of Gastric Emptying after Solid Meals during Intravenous Glucagon-Like Peptide 1 in Patients with Type 2 Diabetes J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2719 - 2725. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Mayo, L. J. Miller, D. Bataille, S. Dalle, B. Goke, B. Thorens, and D. J. Drucker International Union of Pharmacology. XXXV. The Glucagon Receptor Family Pharmacol. Rev., March 1, 2003; 55(1): 167 - 194. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Diabetes | Diabetes Care | Clinical Diabetes | Diabetes Spectrum |