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Diabetes 50:2879-2882, 2001
© 2001 by the American Diabetes Association, Inc.

Brief Genetics Report

Diabetes-Associated HLA-DQ Genes and Birth Weight

Lars C. Stene1,2, Per Magnus1, Kjersti S. Rønningen1, and Geir Joner2

1 Section of Epidemiology, Department of Population Health Sciences, National Institute of Public Health, Oslo, Norway
2 Diabetes Research Center, Aker and Ullevål University Hospitals, Oslo, Norway

An association has recently been described between increased birth weight and increased risk of childhood-onset type 1 diabetes. Whether this relationship is explained by genes associated with both increased birth weight and increased risk of type 1 diabetes is unknown. In the present study, we tested the association between birth weight and HLA-DQ genotypes known to confer risk for type 1 diabetes among 969 nondiabetic children randomly selected from the Norwegian population. We found that HLA genotypes previously shown to confer risk for type 1 diabetes were associated with reduced birth weight (the mean difference in birth weight between the DQB1*0602/DQB1*0602 and DQ8/DQ2 genotypes was 354 g [95% CI 105–604]), which was opposite of that expected if HLA genes explained the birth weight–type 1 diabetes association.


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Copyright © 2001 by the American Diabetes Association.