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Diabetes 50:1200-1205, 2001
© 2001 by the American Diabetes Association, Inc.

The HLA-DPB1–Associated Component of the IDDM1 and Its Relationship to the Major Loci HLA-DQB1, -DQA1, and -DRB1

Francesco Cucca1, Frank Dudbridge3, Miriam Loddo1,2, Anna P. Mulargia1,2, Rosannna Lampis1, Efisio Angius2, Stefano De Virgiliis1, Bobby P.C. Koeleman3, Stephen C. Bain4, Anthony H. Barnett4, Frances Gilchrist5, Heather Cordell2, Ken Welsh6, and John A. Todd3

1 Department of Biomedical Science and Biotechnology, University of Cagliari
2 Pediatric Diabetes Unit, G. Brotzu Hospital, Via Peretti, Cagliari, Sardinia, Italy
3 Wellcome Trust Center for Molecular Mechanisms in Disease, University of Cambridge, Addenbrooks Hospital, Cambridge
4 Department of Medicine, University of Birmingham, Birmingham Heartlands Hospital, Birmingham
5 Royal Brompton Hospital, Fulham Road, London
6 Transplant Immunology, Oxford Transplant Centre, Churchill Hospital, Oxford, U.K.

The major histocompatibility complex (MHC) HLA region on chromosome 6p21 contains the major locus of type 1 diabetes (IDDM1). Common allelic variants at the class II HLA-DRB1, -DQA1, and -DQB1 loci account for the major part of IDDM1. Previous studies suggested that other MHC loci are likely to contribute to IDDM1, but determination of their relative contributions and identities is difficult because of strong linkage disequilibrium between MHC loci. One prime candidate is the polymorphic HLA-DPB1 locus, which (with the DPA1 locus) encodes the third class II antigen–presenting molecule. However, the results obtained in previous studies appear to be contradictory. Therefore, we have analyzed 408 white European families (200 from Sardinia and 208 from the U.K.) using a combination of association tests designed to directly compare the effect of DPB1 variation on the relative predisposition of DR-DQ haplotypes, taking into account linkage disequilibrium between DPB1 and the DRB1, DQA1, and DQB1 loci. In these populations, the overall contribution of DPB1 to IDDM1 is small. The main component of the DPB1 contribution to IDDM1 in these populations appears to be the protection associated with DPB1*0402 on DR4-negative haplotypes. We suggest that the HLA-DP molecule itself contributes to IDDM1.


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