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Diabetes 50:1214-1218, 2001
© 2001 by the American Diabetes Association, Inc.

Polymorphism Screening of Four Genes Encoding Advanced Glycation End-Product Putative Receptors

Association Study With Nephropathy in Type 1 Diabetic Patients

Odette Poirier1, Viviane Nicaud1, Nathalie Vionnet1, Ségolène Raoux1, Lise Tarnow3, Helen Vlassara2, Hans-Henrik Parving3, and François Cambien1

1 Institut National de la Santé et de la Recherche Médicale (INSERM) U525/SC7, Paris, France
2 Mount Sinai Medical Center, New York
3 Steno Diabetes Center, Gentofte, Denmark

Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in 199 type 1 diabetic patients with nephropathy and 193 type 1 diabetic patients without nephropathy. Overall, none of the polymorphisms was strongly associated with nephropathy. The minor allele of a polymorphism located in the promoter region of the RAGE gene (C-1152A) conferred a weak protective effect (P < 0.05) and was associated with a longer duration of nephropathy-free diabetes (P = 0.08).


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