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Diabetes 50:1539-1545, 2001
© 2001 by the American Diabetes Association, Inc.

Liver-Derived IGF-I is of Importance for Normal Carbohydrate and Lipid Metabolism

Klara Sjögren1,2, Kristina Wallenius1, Jun-Li Liu5, Mohammad Bohlooly-Y2, Giovanni Pacini6, Lennart Svensson3, Jan Törnell2, Olle G.P. Isaksson1, Bo Ahrén4, John-Olov Jansson1, and Claes Ohlsson1

1 Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital
2 Department of Physiology, University of Göteborg, Göteborg
3 Astrazeneca R&D, Mölndal
4 Department of Medicine, Lund University, Malmö, Sweden
5 Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland
6 Institute of Systems Science and Biomedical Engineering, National Research Council, Padua, Italy

IGF-I is important for postnatal body growth and exhibits insulin-like effects on carbohydrate metabolism. The function of liver-derived IGF-I is still not established, although we previously demonstrated that liver-derived IGF-I is not required for postnatal body growth. Mice whose IGF-I gene in the liver was inactivated at 24 days of age were used to investigate the long-term role of liver-derived IGF-I for carbohydrate and lipid metabolism. Serum levels of leptin in these mice were increased by >100% at 3 months of age, whereas the fat mass of the mice was decreased by 25% at 13 months of age. The mice became markedly hyperinsulinemic and yet normoglycemic, indicating an adequately compensated insulin resistance. Furthermore, they had increased serum levels of cholesterol. We conclude that liver-derived IGF-I is of importance for carbohydrate and lipid metabolism.


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