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Diabetes 50:1714-1719, 2001
© 2001 by the American Diabetes Association, Inc.

A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans

David E. Cummings1, Jonathan Q. Purnell2, R. Scott Frayo1, Karin Schmidova1, Brent E. Wisse1, and David S. Weigle1

1 University of Washington, VA Puget Sound Health Care System and Harborview Medical Center, Seattle, Washington
2 Oregon Health Sciences University, Portland, Oregon

The recently discovered orexigenic peptide ghrelin is produced primarily by the stomach and circulates in blood at levels that increase during prolonged fasting in rats. When administered to rodents at supraphysiological doses, ghrelin activates hypothalamic neuropeptide Y/agouti gene–related protein neurons and increases food intake and body weight. These findings suggest that ghrelin may participate in meal initiation. As a first step to investigate this hypothesis, we sought to determine whether circulating ghrelin levels are elevated before the consumption of individual meals in humans. Ghrelin, insulin, and leptin were measured by radioimmunoassay in plasma samples drawn 38 times throughout a 24-h period in 10 healthy subjects provided meals on a fixed schedule. Plasma ghrelin levels increased nearly twofold immediately before each meal and fell to trough levels within 1 h after eating, a pattern reciprocal to that of insulin. Intermeal ghrelin levels displayed a diurnal rhythm that was exactly in phase with that of leptin, with both hormones rising throughout the day to a zenith at 0100, then falling overnight to a nadir at 0900. Ghrelin levels sampled during the troughs before and after breakfast correlated strongly with 24-h integrated area under the curve values (r = 0.873 and 0.954, respectively), suggesting that these convenient, single measurements might serve as surrogates for 24-h profiles to estimate overall ghrelin levels. Circulating ghrelin also correlated positively with age (r = 0.701). The clear preprandial rise and postprandial fall in plasma ghrelin levels support the hypothesis that ghrelin plays a physiological role in meal initiation in humans.


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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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Home page
 Mol. Pharmacol.Home page
J.-N. Ma, H. H. Schiffer, A. E. Knapp, J. Wang, K. K. Wong, E. A. Currier, M. Owens, N. R. Nash, L. R. Gardell, M. R. Brann, et al.
Identification of the Atypical L-Type Ca2+ Channel Blocker Diltiazem and Its Metabolites As Ghrelin Receptor Agonists
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[Abstract] [Full Text] [PDF]

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[Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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Radiology, July 1, 2007; 244(1): 138 - 143.
[Abstract] [Full Text] [PDF]

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A Validated Whole-Genome Association Study of Efficient Food Conversion in Cattle
Genetics, July 1, 2007; 176(3): 1893 - 1905.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Deng, A. Hirschberg, T. Worzfeld, J. Y. Penachioni, A. Korostylev, J. M. Swiercz, P. Vodrazka, O. Mauti, E. T. Stoeckli, L. Tamagnone, et al.
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[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
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[Abstract] [Full Text] [PDF]

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J. Endocrinol., May 1, 2007; 193(2): 251 - 258.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
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[Abstract] [Full Text] [PDF]

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[Abstract] [Full Text] [PDF]

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Eur. J. Endocrinol., January 1, 2007; 156(1): 99 - 103.
[Abstract] [Full Text] [PDF]

Home page
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M. Fry, T. D. Hoyda, and A. V. Ferguson
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[Abstract] [Full Text] [PDF]

Home page
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Effects of Obestatin on Energy Balance and Growth Hormone Secretion in Rodents
Endocrinology, January 1, 2007; 148(1): 21 - 26.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
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The Ghrelin Response to Exercise before and after Growth Hormone Administration
J. Clin. Endocrinol. Metab., January 1, 2007; 92(1): 297 - 303.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
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J. Clin. Endocrinol. Metab., January 1, 2007; 92(1): 229 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
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Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R575 - R585.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
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Endocr. Rev., December 1, 2006; 27(7): 736 - 749.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
K. G. Murphy, W. S. Dhillo, and S. R. Bloom
Gut Peptides in the Regulation of Food Intake and Energy Homeostasis
Endocr. Rev., December 1, 2006; 27(7): 719 - 727.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
K. E. Foster-Schubert and D. E. Cummings
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Endocr. Rev., December 1, 2006; 27(7): 779 - 793.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
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Lupin-enriched bread increases satiety and reduces energy intake acutely.
Am. J. Clinical Nutrition, November 1, 2006; 84(5): 975 - 980.
[Abstract] [Full Text] [PDF]

Home page
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Diabetes, November 1, 2006; 55(11): 3038 - 3046.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
M. J. Carlson and D. E. Cummings
Prospects for an anti-ghrelin vaccine to treat obesity.
Mol. Interv., October 1, 2006; 6(5): 249 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Wang, N. R. Basa, A. Shaikh, A. Luckey, D. Heber, D. H. St-Pierre, and Y. Tache
LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implications.
Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G611 - G620.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
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Predictors of Postabsorptive Ghrelin Secretion after Intake of Different Macronutrients
J. Clin. Endocrinol. Metab., October 1, 2006; 91(10): 4124 - 4130.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. Kobelt, M. Goebel, A. Stengel, M. Schmidtmann, I. R. van der Voort, J. J. Tebbe, R. W. Veh, B. F. Klapp, B. Wiedenmann, L. Wang, et al.
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Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R903 - R913.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
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Hunger and satiety: one brain for two?
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R900 - R902.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
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A simple twist of science: the convoluted tale of ghrelin continues.
J. Clin. Endocrinol. Metab., September 1, 2006; 91(9): 3279 - 3280.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Levin, T. Edholm, P. T. Schmidt, P. Gryback, H. Jacobsson, M. Degerblad, C. Hoybye, J. J. Holst, J. F. Rehfeld, P. M. Hellstrom, et al.
Ghrelin Stimulates Gastric Emptying and Hunger in Normal-Weight Humans
J. Clin. Endocrinol. Metab., September 1, 2006; 91(9): 3296 - 3302.
[Abstract] [Full Text] [PDF]

Home page
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J. M. Zigman and J. K. Elmquist
In search of an effective obesity treatment: A shot in the dark or a shot in the arm?
PNAS, August 29, 2006; 103(35): 12961 - 12962.
[Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
H D. Falls, B. D Dayton, D. G Fry, C. A Ogiela, V. G Schaefer, S. Brodjian, R. M Reilly, C. A Collins, and W. Kaszubska
Characterization of ghrelin receptor activity in a rat pituitary cell line RC-4B/C.
J. Mol. Endocrinol., August 1, 2006; 37(1): 51 - 62.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
S Bertoli, P Magni, V Krogh, M Ruscica, E Dozio, G Testolin, and A Battezzati
Is ghrelin a signal of decreased fat-free mass in elderly subjects?
Eur. J. Endocrinol., August 1, 2006; 155(2): 321 - 330.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
F. Bacha and S. A. Arslanian
Ghrelin and Peptide YY in Youth: Are There Race-Related Differences?
J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 3117 - 3122.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
M. E. Gordon and K. H. McKeever
Oral and intravenous carbohydrate challenges decrease active ghrelin concentrations and alter hormones related to control of energy metabolism in horses
J Anim Sci, July 1, 2006; 84(7): 1682 - 1690.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. Xue and B. B. Kahn
AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues
J. Physiol., July 1, 2006; 574(1): 73 - 83.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
P Kobelt, S Helmling, A Stengel, B Wlotzka, V Andresen, B F Klapp, B Wiedenmann, S Klussmann, and H Monnikes
Anti-ghrelin Spiegelmer NOX-B11 inhibits neurostimulatory and orexigenic effects of peripheral ghrelin in rats
Gut, June 1, 2006; 55(6): 788 - 792.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. Dong, T. L. Peeters, B. De Smet, D. Moechars, C. Delporte, P. Vanden Berghe, B. Coulie, M. Tang, and I. Depoortere
Role of Endogenous Ghrelin in the Hyperphagia of Mice with Streptozotocin-Induced Diabetes
Endocrinology, June 1, 2006; 147(6): 2634 - 2642.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
T. O. Mundinger, D. E. Cummings, and G. J. Taborsky Jr
Direct Stimulation of Ghrelin Secretion by Sympathetic Nerves
Endocrinology, June 1, 2006; 147(6): 2893 - 2901.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
S. Gruendel, A. L. Garcia, B. Otto, C. Mueller, J. Steiniger, M. O. Weickert, M. Speth, N. Katz, and C. Koebnick
Carob Pulp Preparation Rich in Insoluble Dietary Fiber and Polyphenols Enhances Lipid Oxidation and Lowers Postprandial Acylated Ghrelin in Humans
J. Nutr., June 1, 2006; 136(6): 1533 - 1538.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
G. Burdyga, A. Varro, R. Dimaline, D. G. Thompson, and G. J. Dockray
Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance
Am J Physiol Gastrointest Liver Physiol, June 1, 2006; 290(6): G1289 - G1297.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
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Ghrelin acts on the dorsal vagal complex to stimulate pancreatic protein secretion
Am J Physiol Gastrointest Liver Physiol, June 1, 2006; 290(6): G1350 - G1358.
[Abstract] [Full Text] [PDF]