Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marchesini, G.
Right arrow Articles by Melchionda, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marchesini, G.
Right arrow Articles by Melchionda, N.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Diabetes 50:1844-1850, 2001
© 2001 by the American Diabetes Association, Inc.

Nonalcoholic Fatty Liver Disease

A Feature of the Metabolic Syndrome

Giulio Marchesini1, Mara Brizi1, Giampaolo Bianchi2, Sara Tomassetti1, Elisabetta Bugianesi3, Marco Lenzi2, Arthur J. McCullough4, Stefania Natale1, Gabriele Forlani1, and Nazario Melchionda1

1 Unit of Metabolic Diseases, Department of Internal Medicine and Gastroenterology, and
2 Department of Internal Medicine, Cardioangiology, and Hepatology, University of Bologna, Italy
3 Gastroenterology Unit, Hospital San Giovanni Battista, University of Turin, Italy
4 Gastroenterology Division, MetroHealth Medical Center, Cleveland, Ohio

Insulin sensitivity (euglycemic clamp, insulin infusion rate: 40 mU · m-2 · min-1) was studied in 30 subjects with biopsy-proven nonalcoholic fatty liver disease (NAFLD), normal glucose tolerance, and a BMI <30 kg/m2. Of those 30 subjects, 9 had pure fatty liver and 21 had evidence of steatohepatitis. In addition, 10 patients with type 2 diabetes under good metabolic control and 10 healthy subjects were studied. Most NAFLD patients had central fat accumulation, increased triglycerides and uric acid, and low HDL cholesterol, irrespective of BMI. Glucose disposal during the clamp was reduced by nearly 50% in NAFLD patients, as well as in patients with normal body weight, to an extent similar to that of the type 2 diabetic patients. Basal free fatty acids were increased, whereas insulin-mediated suppression of lipolysis was less effective (-69% in NAFLD vs. -84% in control subjects; P = 0.003). Postabsorptive hepatic glucose production (HGP), measured by [6,6-2H2]glucose, was normal. In response to insulin infusion, HGP decreased by only 63% of basal in NAFLD vs. 84% in control subjects (P = 0.002). Compared with type 2 diabetic patients, NAFLD patients were characterized by lower basal HGP, but with similarly reduced insulin-mediated suppression of HGP. There was laboratory evidence of iron overload in many NAFLD patients, but clinical, histological, and biochemical data (including insulin sensitivity) were not correlated with iron status. Four subjects were heterozygous for mutation His63Asp of the HFE gene of familiar hemochromatosis. We concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity. NAFLD may be considered an additional feature of the metabolic syndrome, with specific hepatic insulin resistance.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
L. Valenti, R. Rametta, P. Dongiovanni, M. Maggioni, A. Ludovica Fracanzani, M. Zappa, E. Lattuada, G. Roviaro, and S. Fargion
Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis
Diabetes, May 1, 2008; 57(5): 1355 - 1362.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
M. Shibata, Y. Kihara, M. Taguchi, M. Tashiro, and M. Otsuki
Nonalcoholic Fatty Liver Disease Is a Risk Factor for Type 2 Diabetes in Middle-Aged Japanese Men
Diabetes Care, November 1, 2007; 30(11): 2940 - 2944.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
V. Nobili, M. Marcellini, G. Marchesini, E. Vanni, M. Manco, A. Villani, and E. Bugianesi
Intrauterine Growth Retardation, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in Children
Diabetes Care, October 1, 2007; 30(10): 2638 - 2640.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
N. H. Cho, H. C. Jang, S. H. Choi, H. R. Kim, H. K. Lee, J. C.N. Chan, and S. Lim
Abnormal Liver Function Test Predicts Type 2 Diabetes: A community-based prospective study
Diabetes Care, October 1, 2007; 30(10): 2566 - 2568.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
P. Andre, B. Balkau, S. Vol, M. A. Charles, E. Eschwege, and on behalf of the DESIR Study Group
{gamma}-Glutamyltransferase Activity and Development of the Metabolic Syndrome (International Diabetes Federation Definition) in Middle-Aged Men and Women: Data From the Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort
Diabetes Care, September 1, 2007; 30(9): 2355 - 2361.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. Muscari, S. Antonelli, G. Bianchi, G. Cavrini, S. Dapporto, A. Ligabue, C. Ludovico, D. Magalotti, G. Poggiopollini, M. Zoli, et al.
Serum C3 Is a Stronger Inflammatory Marker of Insulin Resistance Than C-Reactive Protein, Leukocyte Count, and Erythrocyte Sedimentation Rate: Comparison study in an elderly population
Diabetes Care, September 1, 2007; 30(9): 2362 - 2368.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
A. M Zivkovic, J B. German, and A. J Sanyal
Comparative review of diets for the metabolic syndrome: implications for nonalcoholic fatty liver disease
Am. J. Clinical Nutrition, August 1, 2007; 86(2): 285 - 300.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
W. V. Zhang, I. Ramzan, and M. Murray
Impaired Microsomal Oxidation of the Atypical Antipsychotic Agent Clozapine in Hepatic Steatosis
J. Pharmacol. Exp. Ther., August 1, 2007; 322(2): 770 - 777.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
K. C. Sung, M. C. Ryan, B. S. Kim, Y. K. Cho, B. I. Kim, and G. M. Reaven
Relationships Between Estimates of Adiposity, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in a Large Group of Nondiabetic Korean Adults
Diabetes Care, August 1, 2007; 30(8): 2113 - 2118.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
A. J.G. Hanley, L. E. Wagenknecht, A. Festa, R. B. D'Agostino Jr., and S. M. Haffner
Alanine Aminotransferase and Directly Measured Insulin Sensitivity in a Multiethnic Cohort: The Insulin Resistance Atherosclerosis Study
Diabetes Care, July 1, 2007; 30(7): 1819 - 1827.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. Azuma, L. K. Heilbronn, J. B. Albu, S. R. Smith, E. Ravussin, D. E. Kelley, and and the Look AHEAD Adipose Research Group
Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus
Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E435 - E442.
[Abstract] [Full Text] [PDF]

Home page
 Epidemiol RevHome page
M. Jakobsen, T Berentzen, T. Sorensen, and K Overvad
Abdominal Obesity and Fatty Liver
Epidemiol. Rev., May 2, 2007; (2007) mxm002v1.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. B. Savage, K. F. Petersen, and G. I. Shulman
Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance
Physiol Rev, April 1, 2007; 87(2): 507 - 520.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
Y. Chang, S. Ryu, E. Sung, and Y. Jang
Higher Concentrations of Alanine Aminotransferase within the Reference Interval Predict Nonalcoholic Fatty Liver Disease
Clin. Chem., April 1, 2007; 53(4): 686 - 692.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
G. Perseghin, G. Lattuada, F. De Cobelli, F. Ragogna, G. Ntali, A. Esposito, E. Belloni, T. Canu, I. Terruzzi, P. Scifo, et al.
Habitual Physical Activity Is Associated With Intrahepatic Fat Content in Humans
Diabetes Care, March 1, 2007; 30(3): 683 - 688.
[Abstract] [Full Text] [PDF]

Home page
 Postgrad. Med. J.Home page
Z. Wang, B. Xia, C. Ma, Z. Hu, X. Chen, and P. Cao
Prevalence and risk factors of fatty liver disease in the Shuiguohu district of Wuhan city, central China
Postgrad. Med. J., March 1, 2007; 83(977): 192 - 195.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. M. Utzschneider and S. E. Kahn
The Role of Insulin Resistance in Nonalcoholic Fatty Liver Disease
J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4753 - 4761.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Perseghin, G. Lattuada, F. De Cobelli, G. Ntali, A. Esposito, A. Burska, E. Belloni, T. Canu, F. Ragogna, P. Scifo, et al.
Serum Resistin and Hepatic Fat Content in Nondiabetic Individuals
J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5122 - 5125.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. J. McCullough
Thiazolidinediones for Nonalcoholic Steatohepatitis -- Promising but Not Ready for Prime Time
N. Engl. J. Med., November 30, 2006; 355(22): 2361 - 2363.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
G. Perseghin, R. Bonfanti, S. Magni, G. Lattuada, F. De Cobelli, T. Canu, A. Esposito, P. Scifo, G. Ntali, F. Costantino, et al.
Insulin resistance and whole body energy homeostasis in obese adolescents with fatty liver disease
Am J Physiol Endocrinol Metab, October 1, 2006; 291(4): E697 - E703.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. Imagawa, S. Fujii, J. Dong, T. Furumoto, T. Kaneko, T. Zaman, Y. Satoh, H. Tsutsui, and B. E Sobel
Hepatocyte Growth Factor Regulates E Box-Dependent Plasminogen Activator Inhibitor Type 1 Gene Expression in HepG2 Liver Cells
Arterioscler. Thromb. Vasc. Biol., October 1, 2006; 26(10): 2407 - 2413.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
C. Franco, J. D Veldhuis, A. Iranmanesh, J. Brandberg, L. Lonn, B. Andersson, B.-A. Bengtsson, J. Svensson, and G. Johannsson
Thigh intermuscular fat is inversely associated with spontaneous GH release in post-menopausal women with abdominal obesity.
Eur. J. Endocrinol., August 1, 2006; 155(2): 261 - 268.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
H. Doege and A. Stahl
Protein-mediated Fatty Acid uptake: novel insights from in vivo models.
Physiology, August 1, 2006; 21: 259 - 268.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
R. Dentin, F. Benhamed, I. Hainault, V. Fauveau, F. Foufelle, J. R.B. Dyck, J. Girard, and C. Postic
Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice.
Diabetes, August 1, 2006; 55(8): 2159 - 2170.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. J. Raubenheimer, M. J. Nyirenda, and B. R. Walker
A Choline-Deficient Diet Exacerbates Fatty Liver but Attenuates Insulin Resistance and Glucose Intolerance in Mice Fed a High-Fat Diet.
Diabetes, July 1, 2006; 55(7): 2015 - 2020.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. L. Setji, N. D. Holland, L. L. Sanders, K. C. Pereira, A. M. Diehl, and A. J. Brown
Nonalcoholic Steatohepatitis and Nonalcoholic Fatty Liver Disease in Young Women with Polycystic Ovary Syndrome
J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1741 - 1747.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. Ortega, J. Koska, A. D. Salbe, P. A. Tataranni, and J. C. Bunt
Serum {gamma}-Glutamyl Transpeptidase Is a Determinant of Insulin Resistance Independently of Adiposity in Pima Indian Children
J. Clin. Endocrinol. Metab., April 1, 2006; 91(4): 1419 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
D. Linden, L. William-Olsson, A. Ahnmark, K. Ekroos, C. Hallberg, H. P. Sjogren, B. Becker, L. Svensson, J. C. Clapham, J. Oscarsson, et al.
Liver-directed overexpression of mitochondrial glycerol-3-phosphate acyltransferase results in hepatic steatosis, increased triacylglycerol secretion and reduced fatty acid oxidation
FASEB J, March 1, 2006; 20(3): 434 - 443.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Z. T. Bloomgarden
Aspects of type 2 diabetes and related insulin-resistant States.
Diabetes Care, March 1, 2006; 29(3): 732 - 740.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
S. G. Wannamethee, A. G. Shaper, L. Lennon, and P. H. Whincup
Hepatic Enzymes, the Metabolic Syndrome, and the Risk of Type 2 Diabetes in Older Men
Diabetes Care, December 1, 2005; 28(12): 2913 - 2918.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
H. S. Park, J. H. Han, K. M. Choi, and S. M. Kim
Relation between elevated serum alanine aminotransferase and metabolic syndrome in Korean adolescents
Am. J. Clinical Nutrition, November 1, 2005; 82(5): 1046 - 1051.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. J.G. Hanley, K. Williams, A. Festa, L. E. Wagenknecht, R. B. D'Agostino Jr, and S. M. Haffner
Liver Markers and Development of the Metabolic Syndrome: The Insulin Resistance Atherosclerosis Study
Diabetes, November 1, 2005; 54(11): 3140 - 3147.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. Stranges, M. Trevisan, J. M. Dorn, J. Dmochowski, and R. P. Donahue
Body Fat Distribution, Liver Enzymes, and Risk of Hypertension: Evidence From the Western New York Study
Hypertension, November 1, 2005; 46(5): 1186 - 1193.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. R. Tovar, I. Torre-Villalvazo, M. Ochoa, A. L. Elias, V. Ortiz, C. A. Aguilar-Salinas, and N. Torres
Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats
J. Lipid Res., September 1, 2005; 46(9): 1823 - 1832.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Y. Aso, S. Wakabayashi, R. Yamamoto, R. Matsutomo, K. Takebayashi, and T. Inukai
Metabolic Syndrome Accompanied by Hypercholesterolemia Is Strongly Associated With Proinflammatory State and Impairment of Fibrinolysis in Patients With Type 2 Diabetes: Synergistic effects of plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor
Diabetes Care, September 1, 2005; 28(9): 2211 - 2216.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Paterson, J. R. Seckl, and J. J. Mullins
Genetic manipulation of 11{beta}-hydroxysteroid dehydrogenases in mice
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R642 - R652.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. J. Lelliott, M. Lopez, R. K. Curtis, N. Parker, M. Laudes, G. Yeo, M. Jimenez-Linan, J. Grosse, A. K. Saha, D. Wiggins, et al.
Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis
FASEB J, July 1, 2005; 19(9): 1108 - 1119.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
M. Nannipieri, C. Gonzales, S. Baldi, R. Posadas, K. Williams, S. M. Haffner, M. P. Stern, and E. Ferrannini
Liver Enzymes, the Metabolic Syndrome, and Incident Diabetes: The Mexico City Diabetes Study
Diabetes Care, July 1, 2005; 28(7): 1757 - 1762.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
Z. T. Bloomgarden
Second World Congress on the Insulin Resistance Syndrome: Insulin resistance syndrome and nonalcoholic fatty liver disease
Diabetes Care, June 1, 2005; 28(6): 1518 - 1523.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. Bugianesi, U. Pagotto, R. Manini, E. Vanni, A. Gastaldelli, R. de Iasio, E. Gentilcore, S. Natale, M. Cassader, M. Rizzetto, et al.
Plasma Adiponectin in Nonalcoholic Fatty Liver Is Related to Hepatic Insulin Resistance and Hepatic Fat Content, Not to Liver Disease Severity
J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3498 - 3504.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Westerbacka, K. Lammi, A.-M. Hakkinen, A. Rissanen, I. Salminen, A. Aro, and H. Yki-Jarvinen
Dietary Fat Content Modifies Liver Fat in Overweight Nondiabetic Subjects
J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2804 - 2809.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
S. B. Biddinger, K. Almind, M. Miyazaki, E. Kokkotou, J. M. Ntambi, and C. R. Kahn
Effects of Diet and Genetic Background on Sterol Regulatory Element-Binding Protein-1c, Stearoyl-CoA Desaturase 1, and the Development of the Metabolic Syndrome
Diabetes, May 1, 2005; 54(5): 1314 - 1323.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Brea, D. Mosquera, E. Martin, A. Arizti, J. L. Cordero, and E. Ros
Nonalcoholic Fatty Liver Disease Is Associated With Carotid Atherosclerosis: A Case-Control Study
Arterioscler. Thromb. Vasc. Biol., May 1, 2005; 25(5): 1045 - 1050.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. B. Savage, K. F. Petersen, and G. I. Shulman
Mechanisms of Insulin Resistance in Humans and Possible Links With Inflammation
Hypertension, May 1, 2005; 45(5): 828 - 833.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
N. R. Qi, J. Wang, V. Zidek, V. Landa, P. Mlejnek, L. Kazdova, M. Pravenec, and T. W. Kurtz
A New Transgenic Rat Model of Hepatic Steatosis and the Metabolic Syndrome
Hypertension, May 1, 2005; 45(5): 1004 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
B. H. Goodpaster, S. Krishnaswami, T. B. Harris, A. Katsiaras, S. B. Kritchevsky, E. M. Simonsick, M. Nevitt, P. Holvoet, and A. B. Newman
Obesity, Regional Body Fat Distribution, and the Metabolic Syndrome in Older Men and Women
Arch Intern Med, April 11, 2005; 165(7): 777 - 783.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
S G Kim, H Y Kim, J A Seo, K W Lee, J H Oh, N H Kim, K M Choi, S H Baik, and D S Choi
Relationship between serum adiponectin concentration, pulse wave velocity and nonalcoholic fatty liver disease
Eur. J. Endocrinol., February 1, 2005; 152(2): 225 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. S. Szczepaniak, P. Nurenberg, D. Leonard, J. D. Browning, J. S. Reingold, S. Grundy, H. H. Hobbs, and R. L. Dobbins
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E462 - E468.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
C. Pagano, G. Soardo, W. Esposito, F. Fallo, L. Basan, D. Donnini, G. Federspil, L. A Sechi, and R. Vettor
Plasma adiponectin is decreased in nonalcoholic fatty liver disease
Eur. J. Endocrinol., January 1, 2005; 152(1): 113 - 118.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
K. Nagao, N. Inoue, Y.-M. Wang, B. Shirouchi, and T. Yanagita
Dietary Conjugated Linoleic Acid Alleviates Nonalcoholic Fatty Liver Disease in Zucker (fa/fa) Rats
J. Nutr., January 1, 2005; 135(1): 9 - 13.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. Krssak, A. Brehm, E. Bernroider, C. Anderwald, P. Nowotny, C. D. Man, C. Cobelli, G. W. Cline, G. I. Shulman, W. Waldhausl, et al.
Alterations in Postprandial Hepatic Glycogen Metabolism in Type 2 Diabetes
Diabetes, December 1, 2004; 53(12): 3048 - 3056.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
S. S. Daskalopoulou, D. P. Mikhailidis, and M. Elisaf
Prevention and Treatment of the Metabolic Syndrome
Angiology, November 1, 2004; 55(6): 589 - 612.
[Abstract] [PDF]

Home page
 ANGIOLOGYHome page
S. S. Daskalopoulou, D. P. Mikhailidis, and M. Elisaf
Prevention and Treatment of the Metabolic Syndrome
Angiology, November 1, 2004; 55(6): 589 - 612.
[Abstract] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
D. H. Lee, K. Silventoinen, D. R. Jacobs Jr., P. Jousilahti, and J. Tuomileto
{gamma}-Glutamyltransferase, Obesity, and the Risk of Type 2 Diabetes: Observational Cohort Study among 20,158 Middle-Aged Men and Women
J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5410 - 5414.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
N. Sattar, O. Scherbakova, I. Ford, D. St. J. O'Reilly, A. Stanley, E. Forrest, P. W. MacFarlane, C. J. Packard, S. M. Cobbe, and J. Shepherd
Elevated Alanine Aminotransferase Predicts New-Onset Type 2 Diabetes Independently of Classical Risk Factors, Metabolic Syndrome, and C-Reactive Protein in the West of Scotland Coronary Prevention Study
Diabetes, November 1, 2004; 53(11): 2855 - 2860.
[Abstract] [Full Text] [PDF]