|
 |
|
|||||||
|
|||||||||
© 2001 by the American Diabetes Association, Inc.
The Neuropeptide Pituitary Adenylate Cyclase–Activating Polypeptide and Islet Function
Department of Medicine, Lund University, Lund, Sweden
The neuropeptide pituitary adenylate cyclase–activating polypeptide (PACAP) is ubiquitously distributed in both the central and peripheral nervous systems and exerts a variety of effects. PACAP is a neuropeptide in pancreatic islets, where it has been suggested as a parasympathetic and sensory neurotransmitter. PACAP stimulates insulin secretion in a glucose-dependent manner, by an effect executed mainly through augmenting the formation of cAMP and stimulating the uptake of calcium. Accumulating evidence in animal studies points to a physiological importance of PACAP in the regulation of the insulin response to feeding. This review summarizes the current knowledge of islet actions and mechanisms and the function of PACAP.
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. S. Qader, J. Jimenez-Feltstrom, M. Ekelund, I. Lundquist, and A. Salehi Expression of islet inducible nitric oxide synthase and inhibition of glucose-stimulated insulin release after long-term lipid infusion in the rat is counteracted by PACAP27 Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1447 - E1455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Seino and T. Shibasaki PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis Physiol Rev, October 1, 2005; 85(4): 1303 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tsunekawa, Y. Miura, N. Yamamoto, Y. Itoh, Y. Ariyoshi, T. Senda, Y. Oiso, and I. Niki Systemic administration of pituitary adenylate cyclase-activating polypeptide maintains beta-cell mass and retards onset of hyperglycaemia in beta-cell-specific calmodulin-overexpressing transgenic mice Eur. J. Endocrinol., May 1, 2005; 152(5): 805 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-C. Henquin Pathways in Beta-Cell Stimulus-Secretion Coupling as Targets for Therapeutic Insulin Secretagogues Diabetes, December 1, 2004; 53(suppl_3): S48 - S58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tomimoto, H. Hashimoto, N. Shintani, K. Yamamoto, Y. Kawabata, K.-I. Hamagami, K. Yamagata, J.-I. Miyagawa, and A. Baba Overexpression of Pituitary Adenylate Cyclase-Activating Polypeptide in Islets Inhibits Hyperinsulinemia and Islet Hyperplasia in Agouti Yellow Mice J. Pharmacol. Exp. Ther., May 1, 2004; 309(2): 796 - 803. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Harndahl, N. Wierup, S. Enerback, H. Mulder, V. C. Manganiello, F. Sundler, E. Degerman, B. Ahren, and L. S. Holst {beta}-Cell-targeted Overexpression of Phosphodiesterase 3B in Mice Causes Impaired Insulin Secretion, Glucose Intolerance, and Deranged Islet Morphology J. Biol. Chem., April 9, 2004; 279(15): 15214 - 15222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Akesson, B. Ahren, V. C. Manganiello, L. S. Holst, G. Edgren, and E. Degerman Dual Effects of Pituitary Adenylate Cyclase-Activating Polypeptide and Isoproterenol on Lipid Metabolism and Signaling in Primary Rat Adipocytes Endocrinology, December 1, 2003; 144(12): 5293 - 5299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamamoto, H. Hashimoto, S. Tomimoto, N. Shintani, J.-i. Miyazaki, F. Tashiro, H. Aihara, T. Nammo, M. Li, K. Yamagata, et al. Overexpression of PACAP in Transgenic Mouse Pancreatic {beta}-Cells Enhances Insulin Secretion and Ameliorates Streptozotocin-induced Diabetes Diabetes, May 1, 2003; 52(5): 1155 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Rachdi, J.-C. Marie, and R. Scharfmann Role for VPAC2 Receptor-Mediated Signals in Pancreas Development Diabetes, January 1, 2003; 52(1): 85 - 92. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Diabetes | Diabetes Care | Clinical Diabetes | Diabetes Spectrum |