HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nakajima, K. Articles by Kawamori, R. Search for Related Content PubMed PubMed Citation Articles by Nakajima, K. Articles by Kawamori, R. Social Bookmarking                What's this?

Chemokine Receptor Genotype Is Associated With Diabetic Nephropathy in Japanese With Type 2 Diabetes

¹ Department of Medicine, Metabolism and Endocrinology, Juntendo University School of Medicine, Tokyo, Japan
² Department of Medicine and Endocrinology, Yanbian University Hospital, Yanji, China

Glomerular infiltration of monocytes/macrophages occurs in diabetic patients with nephropathy, and chemokine receptor signals are thought to play a key role in the development of nephropathy. Recently, polymorphism of the chemokine receptor (CCR)2 coding region V64I and the CCR5 promoter region 59029 (G/A) have been identified. Accordingly, we evaluated the effects of these genotypes on diabetic nephropathy. CCR2 V64I and CCR5 59029 (G/A) were detected by polymerase chain reaction–restriction fragment–length polymorphism in 401 patients with type 2 diabetes who had a serum creatinine <2.0 mg/dl. Although the CCR2 V64I genotype showed no association with nephropathy, the frequency of the CCR5 59029 A-positive genotype (G/A or A/A) was significantly higher in patients with microalbuminuria (urinary albumin-to-creatinine ratio [ACR] 30 and <300 mg/gCre, 86%) and patients with macroalbuminuria (ACR 300 mg/gCre, 87%) than in patients with normoalbuminuria (ACR <30 mg/gCre, 75%; P = 0.0095). Polytomic logistic regression analysis showed that the CCR5 59029 A-positive genotype was associated with nephropathy (odds ratio 2.243, P = 0.0074). These results suggest that the CCR5 promoter 59029 A genotype may be an independent risk factor for diabetic nephropathy in patients with type 2 diabetes.

CiteULike

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				S. Maeda Review: Genetics of diabetic nephropathy Therapeutic Advances in Cardiovascular Disease, October 1, 2008; 2(5): 363 - 371. [Abstract] [PDF]

				D.-A. Tregouet, P.-H. Groop, S. McGinn, C. Forsblom, S. Hadjadj, M. Marre, H.-H. Parving, L. Tarnow, R. Telgmann, T. Godefroy, et al. G/T Substitution in Intron 1 of the UNC13B Gene Is Associated With Increased Risk of Nephropathy in Patients With Type 1 Diabetes Diabetes, October 1, 2008; 57(10): 2843 - 2850. [Abstract] [Full Text] [PDF]

				W. M. Mlynarski, G. P. Placha, P. P. Wolkow, J. P. Bochenski, J. H. Warram, and A. S. Krolewski Risk of Diabetic Nephropathy in Type 1 Diabetes Is Associated With Functional Polymorphisms in RANTES Receptor Gene (CCR5): A Sex-Specific Effect Diabetes, November 1, 2005; 54(11): 3331 - 3335. [Abstract] [Full Text] [PDF]

				T. Wada, H. Yokoyama, K. Matsushima, and K.-i. Kobayashi Monocyte chemoattractant protein-1: does it play a role in diabetic nephropathy? Nephrol. Dial. Transplant., March 1, 2003; 18(3): 457 - 459. [Full Text] [PDF]

				K. Nakajima, Y. Tanaka, T. Nomiyama, T. Ogihara, F. Ikeda, R. Kanno, N. Iwashita, K. Sakai, H. Watada, T. Onuma, et al. RANTES Promoter Genotype Is Associated With Diabetic Nephropathy in Type 2 Diabetic Subjects Diabetes Care, March 1, 2003; 26(3): 892 - 898. [Abstract] [Full Text] [PDF]

				W. W. Hancock Chemokines and Transplant Immunobiology J. Am. Soc. Nephrol., March 1, 2002; 13(3): 821 - 824. [Full Text] [PDF]