HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Erratum (v51,p3591) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mei, Q. Articles by Taborsky, G. J. Search for Related Content PubMed PubMed Citation Articles by Mei, Q. Articles by Taborsky, G. J., Jr Social Bookmarking                What's this?

Early, Selective, and Marked Loss of Sympathetic Nerves From the Islets of BioBreeder Diabetic Rats

From the Division of Endocrinology and Metabolism, Department of Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, Washington; and the University of Washington, Seattle, Washington

To discover whether islet sympathetic nerves are damaged during the autoimmune destruction of islet B-cells, we immunostained sections of pancreas from BioBreeder (BB) diabetic rats, using antibodies against vesicular monoamine transporter 2 (VMAT2), a marker of sympathetic nerve terminals. We found a marked decrease in the VMAT2-positive fiber area in the islets of BB rats that had been diabetic for only 1–2 weeks compared with their nondiabetic controls. In contrast, there was no significant decrease in the VMAT2-positive fiber area in the exocrine pancreas in these early diabetic BB rats. Furthermore, streptozotocin-diabetic rats showed no decrease in VMAT2-positive fiber area in their islets compared with controls. The classical diabetic autonomic neuropathy (DAN) that eventually occurs in the heart was not present in BB diabetic rats at this early stage as evidenced by normal cardiac VMAT2 immunostaining and normal cardiac norepinephrine content. Also, in contrast to DAN, this islet neuropathy did not worsen with duration of diabetes. These data provide evidence of a heretofore unrecognized early sympathetic islet neuropathy (eSIN). Because eSIN occurs selectively in the islet, is rapid in onset, and is associated with autoimmune but not chemically induced diabetes, it is distinct from DAN in location, time course, and mechanism.

CiteULike

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				M. C. Puertas, J. Carrillo, X. Pastor, R. M. Ampudia, R. Planas, A. Alba, R. Bruno, R. Pujol-Borrell, J. M. Estanyol, M. Vives-Pi, et al. Peripherin Is a Relevant Neuroendocrine Autoantigen Recognized by Islet-Infiltrating B Lymphocytes J. Immunol., May 15, 2007; 178(10): 6533 - 6539. [Abstract] [Full Text] [PDF]

				R H Straub, R Wiest, U G Strauch, P Harle, and J Scholmerich The role of the sympathetic nervous system in intestinal inflammation. Gut, November 1, 2006; 55(11): 1640 - 1649. [Full Text] [PDF]

				Z. T. Bloomgarden Glycemic treatment in type 1 and type 2 diabetes. Diabetes Care, November 1, 2006; 29(11): 2549 - 2555. [Full Text] [PDF]

				P Harle, R H Straub, R Wiest, A Mayer, J Scholmerich, F Atzeni, M Carrabba, M Cutolo, and P Sarzi-Puttini Increase of sympathetic outflow measured by neuropeptide Y and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with systemic lupus erythematosus and rheumatoid arthritis: another example of uncoupling of response systems Ann Rheum Dis, January 1, 2006; 65(1): 51 - 56. [Abstract] [Full Text] [PDF]

				P. E. Cryer Mechanisms of Hypoglycemia-Associated Autonomic Failure and Its Component Syndromes in Diabetes Diabetes, December 1, 2005; 54(12): 3592 - 3601. [Abstract] [Full Text] [PDF]

				R H Straub, K Stebner, P Harle, F Kees, W Falk, and J Scholmerich Key role of the sympathetic microenvironment for the interplay of tumour necrosis factor and interleukin 6 in normal but not in inflamed mouse colon mucosa Gut, August 1, 2005; 54(8): 1098 - 1106. [Abstract] [Full Text] [PDF]

				J. Carrillo, M. C. Puertas, A. Alba, R. M. Ampudia, X. Pastor, R. Planas, N. Riutort, N. Alonso, R. Pujol-Borrell, P. Santamaria, et al. Islet-infiltrating B-Cells in Nonobese Diabetic Mice Predominantly Target Nervous System Elements Diabetes, January 1, 2005; 54(1): 69 - 77. [Abstract] [Full Text] [PDF]

				A. Maffei, Z. Liu, P. Witkowski, F. Moschella, G. D. Pozzo, E. Liu, K. Herold, R. J. Winchester, M. A. Hardy, and P. E. Harris Identification of Tissue-Restricted Transcripts in Human Islets Endocrinology, October 1, 2004; 145(10): 4513 - 4521. [Abstract] [Full Text] [PDF]

				T. O. Mundinger, Q. Mei, D. P. Figlewicz, A. Lernmark, and G. J. Taborsky Jr Impaired glucagon response to sympathetic nerve stimulation in the BB diabetic rat: effect of early sympathetic islet neuropathy Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E1047 - E1054. [Abstract] [Full Text] [PDF]