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Diabetes 51:3141-3150, 2002
© 2002 by the American Diabetes Association, Inc.

Perspectives in Diabetes

While Tinkering With the ß-Cell... Metabolic Regulatory Mechanisms and New Therapeutic Strategies

American Diabetes Association Lilly Lecture, 2001

Christopher B. Newgard

From the Touchstone Center for Diabetes Research and Departments of Biochemistry & Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas

A common feature of the two major forms of human diabetes is the partial or complete loss of insulin secretion from ß-cells in the pancreatic islets of Langerhans. In this article, we review the development of a set of tools for studying ß-cell biology and their application to understanding of fuel-mediated insulin secretion and enhancement of ß-cell survival. Insights into these basic issues are likely to be useful for the design of new drug and cell-based diabetes therapies.


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Copyright © 2002 by the American Diabetes Association.