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Diabetes 51:3326-3330, 2002
© 2002 by the American Diabetes Association, Inc.

No Association Between lck Gene Polymorphisms and Protein Level in Type 1 Diabetes

Solange Nervi1, Sandra Nicodeme2, Corinne Gartioux2, Catherine Atlan1, Marc Lathrop2, Denis Reviron3, Philippe Naquet4, Fumihiko Matsuda2, Jean Imbert5, and Bernard Vialettes1

1 Université de la Méditerranée, CHU Sainte-Marguerite, Marseille, France
2 Centre National de Génotypage, rue Gaston Crémieux, Evry, France
3 Etablissement Français du Sang, Marseille, France
4 Centre d’Immunologie INSERM-CNRS de Marseille-Luminy, Marseille, France
5 INSERM U119, Marseille, France

We previously described a reduced expression of the protein tyrosine kinase Lck in T-cells from type 1 diabetic patients, the origin of which is still unknown. The human lck gene, located on chromosome 1p35-34.3, was evaluated as a candidate susceptibility gene for type 1 diabetes. A molecular scan of the sequence variations in the coding, the relevant promoter, and most of the intronic sequences of the lck gene (representing a total of 10.5 kb fragment) was performed in 187 Caucasian subjects including 91 type 1 diabetic patients and 96 normoglycemic control subjects. We identified 35 sequence variations, including one deletion and 34 single nucleotide polymorphisms (SNPs), 33 of them being new. Four variants were frequent but not significantly associated with diabetes or Lck protein level. Of the SNP variants, 11 were only found within the diabetic population and some were associated with low Lck protein levels. The low frequency of these polymorphisms did not permit any statistically significant correlations with the disease status, suggesting that the lck gene probably does not contribute to genetic susceptibility to type 1 diabetes.


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J. S. Hulme, B. J. Barratt, R. C.J. Twells, J. D. Cooper, C. E. Lowe, J. M.M. Howson, A. C. Lam, L. J. Smink, D. A. Savage, D. E. Undlien, et al.
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Copyright © 2002 by the American Diabetes Association.