|
 |
|
|||||||
|
|||||||||
Diabetes 51:3347-3349, 2002
© 2002 by the American Diabetes Association, Inc.
Brief Genetics Reports |
Interleukin-18 Promoter Polymorphisms in Type 1 Diabetes
1 Department of Endocrinology, Diabetology and Internal Medicine, Academy of Bialystok, Bialystok, Poland
2 First Department of General Surgery Medical Academy of Bialystok, Bialystok, Poland
Type 1 diabetes is believed to be a Th1 lymphocyte–mediated disease, and both environmental and genetic factors play a role in its pathogenesis. It was recently found that interleukin (IL)-18 acts as a proinflammatory cytokine and, in synergy with IL-12, promotes development of Th1 lymphocyte response by induction of 
-interferon production. The aim of our study was to evaluate the frequency of known polymorphisms in the IL-18 promoter in patients with type 1 diabetes in comparison with healthy control subjects, since higher levels of IL-18 were recently reported in the subclinical stage of type 1 diabetes. We studied two recently described single-nucleotide polymorphisms of the promoter of IL-18 gene at the position -137 and -607, which have been suggested to cause differences in transcription factor binding and have an impact on IL-18 gene activity. The genotype distribution differed significantly between patients with type 1 diabetes and control subjects. The difference reflected an increase in the GC genotypes and a decrease in GG genotypes at position -137 in the promoter of IL-18 gene. AA genotype at position -607 was found only in the control group. The results also demonstrated that the contribution of -137GC genotypes to genetic susceptibility to type 1 diabetes differs depending on the combination of IL-18 promotor gene haplotypes. Our study suggests the first evidence of an association between type 1 diabetes and polymorphisms in the promoter of IL-18 gene.
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Bossu, A. Ciaramella, M. L. Moro, L. Bellincampi, S. Bernardini, G. Federici, A. Trequattrini, F. Macciardi, I. Spoletini, F. Di Iulio, et al. Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease J. Neurol. Neurosurg. Psychiatry, August 1, 2007; 78(8): 807 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Short, B. Catchpole, L. J. Kennedy, A. Barnes, N. Fretwell, C. Jones, W. Thomson, and W. E.R. Ollier Analysis of Candidate Susceptibility Genes in Canine Diabetes J. Hered., July 4, 2007; (2007) esm048v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Szeszko, J. M.M. Howson, J. D. Cooper, N. M. Walker, R. C.J. Twells, H. E. Stevens, S. L. Nutland, and J. A. Todd Analysis of Polymorphisms of the Interleukin-18 Gene in Type 1 Diabetes and Hardy-Weinberg Equilibrium Testing Diabetes, February 1, 2006; 55(2): 559 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Kelly, C. M. Greene, G. Meachery, M. O'Mahony, P. M. Gallagher, C. C. Taggart, S. J. O'Neill, and N. G. McElvaney Endotoxin Up-regulates Interleukin-18: Potential Role for Gram-Negative Colonization in Sarcoidosis Am. J. Respir. Crit. Care Med., November 15, 2005; 172(10): 1299 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kretowski, I. Kinalska, K. Esposito, F. Nappo, R. Marfella, G. Giugliano, F. Giugliano, M. Ciotola, D. Giugliano, L. Quagliaro, et al. Serum Levels of Interleukin-18--a Potential Marker of Cardiovascular Death--Could Be Determined by Genetic Predisposition * Response Circulation, June 10, 2003; 107 (22): e206 - e207. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Diabetes | Diabetes Care | Clinical Diabetes | Diabetes Spectrum |