HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Marculescu, R. Articles by Mannhalter, C. Search for Related Content PubMed PubMed Citation Articles by Marculescu, R. Articles by Mannhalter, C. Social Bookmarking                What's this?

Interleukin-1 Receptor Antagonist Genotype Is Associated With Coronary Atherosclerosis in Patients With Type 2 Diabetes

¹ Department of Laboratory Medicine, School of Medicine, University of Vienna, Vienna, Austria
² Department of Internal Medicine II, Division of Angiology, School of Medicine, University of Vienna, Vienna, Austria
³ Department of Internal Medicine II, Division of Cardiology, School of Medicine, University of Vienna, Vienna, Austria
⁴ Department of Business Administration, School of Business, Economics and Computer Science, University of Vienna, Vienna, Austria

Recently, inflammation has received considerable attention in the pathogenesis of both type 2 diabetes and atherosclerosis. The interleukin-1 receptor antagonist (IL-1ra) is a major modulator of the interleukin-1 pro-inflammatory pathway. We studied the relationship between a variable number tandem repeat (VNTR) polymorphism in intron 2 of the IL-1ra gene (IL1RN) and coronary artery disease (CAD) in patients with and without type 2 diabetes, following 787 consecutive patients admitted for suspected CAD. According to the current criteria of the American Diabetes Association, 250 patients had type 2 diabetes. In this group of patients, allele 2 carriers (n = 108) had an increased prevalence of CAD compared with noncarriers (85.2 vs. 73.2%), a difference that remained significant in a multivariate logistic regression model (odds ratio 2.2, 95% CI 1.1–4.3, P = 0.02). No association of CAD with allele 2 carrier status was present among nondiabetic patients (n = 537). Enzyme-linked immunosorbent assays showed decreased baseline plasma levels of IL-1ra in patients with type 2 diabetes, which may in part explain the role of the IL1RN VNTR in these patients.

CiteULike

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				K. Drosatos, D. Sanoudou, K. E. Kypreos, D. Kardassis, and V. I. Zannis A Dominant Negative Form of the Transcription Factor c-Jun Affects Genes That Have Opposing Effects on Lipid Homeostasis in Mice J. Biol. Chem., July 6, 2007; 282(27): 19556 - 19564. [Abstract] [Full Text] [PDF]

				E. Ruotsalainen, U. Salmenniemi, I. Vauhkonen, J. Pihlajamaki, K. Punnonen, S. Kainulainen, and M. Laakso Changes in Inflammatory Cytokines Are Related to Impaired Glucose Tolerance in Offspring of Type 2 Diabetic Subjects Diabetes Care, December 1, 2006; 29(12): 2714 - 2720. [Abstract] [Full Text] [PDF]

				K. CLEMENT, N. VIGUERIE, C. POITOU, C. CARETTE, V. PELLOUX, C. A. CURAT, A. SICARD, S. ROME, A. BENIS, J.-D. ZUCKER, et al. Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects FASEB J, November 1, 2004; 18(14): 1657 - 1669. [Abstract] [Full Text] [PDF]

				K. Maedler, P. Sergeev, J. A. Ehses, Z. Mathe, D. Bosco, T. Berney, J.-M. Dayer, M. Reinecke, P. A. Halban, and M. Y. Donath Leptin modulates {beta} cell expression of IL-1 receptor antagonist and release of IL-1{beta} in human islets PNAS, May 25, 2004; 101(21): 8138 - 8143. [Abstract] [Full Text] [PDF]

				P. Apfalter, M. R. Hammerschlag, J. Boman, J. Wojta, K. Huber, and I. Huk Reliability of Nested PCR for the Detection of Chlamydia pneumoniae in Carotid Artery Atherosclerosis Stroke, July 1, 2003; 34 (7): e73 - e75. [Full Text] [PDF]