HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 51.02.02.db01-1276v1 51/2/271    most recent Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Obici, S. Articles by Rossetti, L. Search for Related Content PubMed PubMed Citation Articles by Obici, S. Articles by Rossetti, L. Social Bookmarking                What's this?

Central Administration of Oleic Acid Inhibits Glucose Production and Food Intake

From the Departments of Medicine and Molecular Pharmacology, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York

The hypothalamus and other regions within the central nervous system (CNS) link the sensing of nutrients to the control of metabolism and feeding behavior. Here, we report that intracerebroventricular (ICV) administration of the long-chain fatty acid oleic acid markedly inhibits glucose production and food intake. The anorectic effect of oleic acid was independent of leptin and was accompanied by a decrease in the hypothalamic expression of neuropeptide Y. The short-chain fatty acid octanoic acid failed to reproduce the metabolic effects of oleic acid, and ICV coadministration of inhibitors of ATP-sensitive K⁺ channels blunted the effect of oleic acid on glucose production. This is the first demonstration that fatty acids can signal nutrient availability to the CNS, which in turn limits further delivery of nutrients to the circulation.

CiteULike

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				D. A. Sandoval, D. Bagnol, S. C. Woods, D. A. D'Alessio, and R. J. Seeley Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake Diabetes, August 1, 2008; 57(8): 2046 - 2054. [Abstract] [Full Text] [PDF]

				Y. C. L. Tung, D. Rimmington, S. O'Rahilly, and A. P. Coll Pro-Opiomelanocortin Modulates the Thermogenic and Physical Activity Responses to High-Fat Feeding and Markedly Influences Dietary Fat Preference Endocrinology, November 1, 2007; 148(11): 5331 - 5338. [Abstract] [Full Text] [PDF]

				S. Gao, K. P. Kinzig, S. Aja, K. A. Scott, W. Keung, S. Kelly, K. Strynadka, S. Chohnan, W. W. Smith, K. L. K. Tamashiro, et al. From the Cover: Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake PNAS, October 30, 2007; 104(44): 17358 - 17363. [Abstract] [Full Text] [PDF]

				G. J. Morton Hypothalamic leptin regulation of energy homeostasis and glucose metabolism J. Physiol., September 1, 2007; 583(2): 437 - 443. [Abstract] [Full Text] [PDF]

				N. Marty, M. Dallaporta, and B. Thorens Brain Glucose Sensing, Counterregulation, and Energy Homeostasis Physiology, August 1, 2007; 22(4): 241 - 251. [Abstract] [Full Text] [PDF]

				C. D. Morrison, X. Xi, C. L. White, J. Ye, and R. J. Martin Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E165 - E171. [Abstract] [Full Text] [PDF]

				M. Qatanani and M. A. Lazar Mechanisms of obesity-associated insulin resistance: many choices on the menu Genes & Dev., June 15, 2007; 21(12): 1443 - 1455. [Abstract] [Full Text] [PDF]

				N. Simler, A. Malgoyre, N. Koulmann, A. Alonso, A. Peinnequin, and A. X. Bigard Hypoxic stimulus alters hypothalamic AMP-activated protein kinase phosphorylation concomitant to hypophagia J Appl Physiol, June 1, 2007; 102(6): 2135 - 2141. [Abstract] [Full Text] [PDF]

				X.-j. Yang, J. Mastaitis, T. Mizuno, and C. V. Mobbs Glucokinase Regulates Reproductive Function, Glucocorticoid Secretion, Food Intake, and Hypothalamic Gene Expression Endocrinology, April 1, 2007; 148(4): 1928 - 1932. [Abstract] [Full Text] [PDF]

				A. Benani, S. Troy, M. C. Carmona, X. Fioramonti, A. Lorsignol, C. Leloup, L. Casteilla, and L. Penicaud Role for Mitochondrial Reactive Oxygen Species in Brain Lipid Sensing: Redox Regulation of Food Intake Diabetes, January 1, 2007; 56(1): 152 - 160. [Abstract] [Full Text] [PDF]

				M. J. Wolfgang and M. D. Lane The Role of Hypothalamic Malonyl-CoA in Energy Homeostasis J. Biol. Chem., December 8, 2006; 281(49): 37265 - 37269. [Abstract] [Full Text] [PDF]

				S. C. Woods, S. C. Benoit, and D. J. Clegg The Brain-Gut-Islet Connection Diabetes, December 1, 2006; 55(Supplement_2): S114 - S121. [Abstract] [Full Text] [PDF]

				B. E. Levin, L. Kang, N. M. Sanders, and A. A. Dunn-Meynell Role of Neuronal Glucosensing in the Regulation of Energy Homeostasis Diabetes, December 1, 2006; 55(Supplement_2): S122 - S130. [Abstract] [Full Text] [PDF]

				S. Migrenne, C. Cruciani-Guglielmacci, L. Kang, R. Wang, C. Rouch, A.-L. Lefevre, A. Ktorza, V. H. Routh, B. E. Levin, and C. Magnan Fatty Acid Signaling in the Hypothalamus and the Neural Control of Insulin Secretion Diabetes, December 1, 2006; 55(Supplement_2): S139 - S144. [Abstract] [Full Text] [PDF]

				A. B. Loucks The Response of Luteinizing Hormone Pulsatility to 5 Days of Low Energy Availability Disappears by 14 Years of Gynecological Age J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 3158 - 3164. [Abstract] [Full Text] [PDF]

				E. Prodi and S. Obici Minireview: The Brain as a Molecular Target for Diabetic Therapy Endocrinology, June 1, 2006; 147(6): 2664 - 2669. [Abstract] [Full Text] [PDF]

				M. J. Wolfgang, T. Kurama, Y. Dai, A. Suwa, M. Asaumi, S.-i. Matsumoto, S. H. Cha, T. Shimokawa, and M. D. Lane The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis PNAS, May 9, 2006; 103(19): 7282 - 7287. [Abstract] [Full Text] [PDF]

				M. Lopez, C. J. Lelliott, S. Tovar, W. Kimber, R. Gallego, S. Virtue, M. Blount, M. J. Vazquez, N. Finer, T. J. Powles, et al. Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA. Diabetes, May 1, 2006; 55(5): 1327 - 1336. [Abstract] [Full Text] [PDF]

				I. Bady, N. Marty, M. Dallaporta, M. Emery, J. Gyger, D. Tarussio, M. Foretz, and B. Thorens Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding. Diabetes, April 1, 2006; 55(4): 988 - 995. [Abstract] [Full Text] [PDF]

				J. C. Molero, S. G. Waring, A. Cooper, N. Turner, R. Laybutt, G. J. Cooney, and D. E. James Casitas b-Lineage Lymphoma-Deficient Mice Are Protected Against High-Fat Diet-Induced Obesity and Insulin Resistance Diabetes, March 1, 2006; 55(3): 708 - 715. [Abstract] [Full Text] [PDF]

				F. Kreier, Y. S. Kap, T. C. Mettenleiter, C. van Heijningen, J. van der Vliet, A. Kalsbeek, H. P. Sauerwein, E. Fliers, J. A. Romijn, and R. M. Buijs Tracing from Fat Tissue, Liver, and Pancreas: A Neuroanatomical Framework for the Role of the Brain in Type 2 Diabetes Endocrinology, March 1, 2006; 147(3): 1140 - 1147. [Abstract] [Full Text] [PDF]

				K. Proulx, D. Cota, T. R. Castaneda, M. H. Tschop, D. A. D'Alessio, P. Tso, S. C. Woods, and R. J. Seeley Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R729 - R737. [Abstract] [Full Text] [PDF]

				B. E. Levin and C. M. Patterson Exercising the Obese Brain: Resetting the Defended Body Weight Endocrinology, April 1, 2005; 146(4): 1674 - 1675. [Full Text] [PDF]

				H.-R. Berthoud A new role for leptin as a direct satiety signal from the stomach Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R796 - R797. [Full Text] [PDF]

				M. W. Schwartz and D. Porte Jr. Diabetes, Obesity, and the Brain Science, January 21, 2005; 307(5708): 375 - 379. [Abstract] [Full Text] [PDF]

				K. L. Teff and R. R. Townsend Prolonged Mild Hyperglycemia Induces Vagally Mediated Compensatory Increase in C-Peptide Secretion in Humans J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5606 - 5613. [Abstract] [Full Text] [PDF]

				T. Alquier and B. B. Kahn Peripheral Signals Set the Tone for Central Regulation of Metabolism Endocrinology, September 1, 2004; 145(9): 4022 - 4024. [Full Text] [PDF]

				A. Kalsbeek, S. La Fleur, C. Van Heijningen, and R. M. Buijs Suprachiasmatic GABAergic Inputs to the Paraventricular Nucleus Control Plasma Glucose Concentrations in the Rat via Sympathetic Innervation of the Liver J. Neurosci., September 1, 2004; 24(35): 7604 - 7613. [Abstract] [Full Text] [PDF]

				C. Perrin, C. Knauf, and R. Burcelin Intracerebroventricular Infusion of Glucose, Insulin, and the Adenosine Monophosphate-Activated Kinase Activator, 5-Aminoimidazole-4-Carboxamide-1-{beta}-D-Ribofuranoside, Controls Muscle Glycogen Synthesis Endocrinology, September 1, 2004; 145(9): 4025 - 4033. [Abstract] [Full Text] [PDF]

				K.G. Murphy and S.R. Bloom Gut hormones in the control of appetite Exp Physiol, September 1, 2004; 89(5): 507 - 516. [Abstract] [Full Text] [PDF]

				R. J. McCrimmon, X. Fan, Y. Ding, W. Zhu, R. J. Jacob, and R. S. Sherwin Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus Diabetes, August 1, 2004; 53(8): 1953 - 1958. [Abstract] [Full Text] [PDF]

				G.-Q. Chang, O. Karatayev, Z. Davydova, and S. F. Leibowitz Circulating Triglycerides Impact on Orexigenic Peptides and Neuronal Activity in Hypothalamus Endocrinology, August 1, 2004; 145(8): 3904 - 3912. [Abstract] [Full Text] [PDF]

				K. Morgan, S. Obici, and L. Rossetti Hypothalamic Responses to Long-chain Fatty Acids Are Nutritionally Regulated J. Biol. Chem., July 23, 2004; 279(30): 31139 - 31148. [Abstract] [Full Text] [PDF]

				M. Miyazaki, A. Dobrzyn, W. C. Man, K. Chu, H. Sampath, H.-J. Kim, and J. M. Ntambi Stearoyl-CoA Desaturase 1 Gene Expression Is Necessary for Fructose-mediated Induction of Lipogenic Gene Expression by Sterol Regulatory Element-binding Protein-1c-dependent and -independent Mechanisms J. Biol. Chem., June 11, 2004; 279(24): 25164 - 25171. [Abstract] [Full Text] [PDF]

				S. C. Woods Gastrointestinal Satiety Signals I. An overview of gastrointestinal signals that influence food intake Am J Physiol Gastrointest Liver Physiol, January 1, 2004; 286(1): G7 - G13. [Abstract] [Full Text] [PDF]

				S. Obici and L. Rossetti Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance Endocrinology, December 1, 2003; 144(12): 5172 - 5178. [Abstract] [Full Text] [PDF]

				F. Kreier, A. Yilmaz, A. Kalsbeek, J. A. Romijn, H. P. Sauerwein, E. Fliers, and R. M. Buijs Hypothesis: Shifting the Equilibrium From Activity to Food Leads to Autonomic Unbalance and the Metabolic Syndrome Diabetes, November 1, 2003; 52(11): 2652 - 2656. [Abstract] [Full Text] [PDF]

				M. Miyazaki, M. J. Jacobson, W. C. Man, P. Cohen, E. Asilmaz, J. M. Friedman, and J. M. Ntambi Identification and Characterization of Murine SCD4, a Novel Heart-specific Stearoyl-CoA Desaturase Isoform Regulated by Leptin and Dietary Factors J. Biol. Chem., September 5, 2003; 278(36): 33904 - 33911. [Abstract] [Full Text] [PDF]

				M. Gilbert, C. Magnan, S. Turban, J. Andre, and M. Guerre-Millo Leptin Receptor-Deficient Obese Zucker Rats Reduce Their Food Intake in Response to a Systemic Supply of Calories From Glucose Diabetes, February 1, 2003; 52(2): 277 - 282. [Abstract] [Full Text] [PDF]

				M. Merkel, R. H. Eckel, and I. J. Goldberg Lipoprotein lipase: genetics, lipid uptake, and regulation J. Lipid Res., December 1, 2002; 43(12): 1997 - 2006. [Abstract] [Full Text] [PDF]

				D. J. Clegg, M. D. Wortman, S. C. Benoit, C. C. McOsker, and R. J. Seeley Comparison of Central and Peripheral Administration of C75 on Food Intake, Body Weight, and Conditioned Taste Aversion Diabetes, November 1, 2002; 51(11): 3196 - 3201. [Abstract] [Full Text] [PDF]