Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jensen, C. B.
Right arrow Articles by Vaag, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jensen, C. B.
Right arrow Articles by Vaag, A. A.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Diabetes 51:1271-1280, 2002
© 2002 by the American Diabetes Association, Inc.

Early Differential Defects of Insulin Secretion and Action in 19-Year-Old Caucasian Men Who Had Low Birth Weight

Christine B. Jensen1, Heidi Storgaard1, Flemming Dela2,3, Jens Juul Holst4, Sten Madsbad1, and Allan A. Vaag1,5

1 Department of Endocrinology and Clinical Research Unit, Hvidovre University Hospital, Hvidovre, Denmark
2 Copenhagen Muscle Research Center, Rigshospitalet, Copenhagen, Denmark
3 Department of Clinical Physiology and Nuclear Medicine, Herlev Hospital, Herlev, Denmark
4 Department of Medical Physiology, the Panum Institute, Copenhagen, Denmark
5 Steno Diabetes Center, Gentofte, Denmark

Several studies have linked low birth weight (LBW) and type 2 diabetes. We investigated hepatic and peripheral insulin action including intracellular glucose metabolism in 40 19-year-old men (20 LBW, 20 matched control subjects), using the hyperinsulinemic-euglycemic clamp technique at two physiological insulin levels (10 and 40 mU/m2 per min), indirect calorimetry, and [3-3H]glucose. Insulin secretion was examined during an oral and intravenous glucose tolerance test. Fasting p-glucose was higher in the LBW group (5.6 ± 0.1 vs. 5.4 ± 0.1; P < 0.05). Basal plasma glycerol concentrations were significantly lower in the LBW group. Insulin-stimulated glycolytic flux was significantly reduced, and suppression of endogenous glucose production was enhanced in the LBW group. Nevertheless, basal and insulin-stimulated rates of whole-body peripheral glucose disposal, glucose oxidation, lipid oxidation, exogenous glucose storage, and nonoxidative glucose metabolism were similar in the two groups. Insulin secretion was reduced by 30% in the LBW group, when expressed relative to insulin sensitivity (disposition index = insulin secretion x insulin action). We propose that reduced insulin-stimulated glycolysis precedes overt insulin resistance in LBW men. A lower insulin secretion may contribute to impaired glucose tolerance and ultimately lead to diabetes.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Physiol.Home page
J. A. Owens, K. L. Gatford, M. J. De Blasio, L. J. Edwards, I. C. McMillen, and A. L. Fowden
Restriction of placental growth in sheep impairs insulin secretion but not sensitivity before birth
J. Physiol., November 1, 2007; 584(3): 935 - 949.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
J. A. Owens, P. Thavaneswaran, M. J. De Blasio, I. C. McMillen, J. S. Robinson, and K. L. Gatford
Sex-specific effects of placental restriction on components of the metabolic syndrome in young adult sheep
Am J Physiol Endocrinol Metab, June 1, 2007; 292(6): E1879 - E1889.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. B. Jensen, H. Storgaard, S. Madsbad, E. A. Richter, and A. A. Vaag
Altered Skeletal Muscle Fiber Composition and Size Precede Whole-Body Insulin Resistance in Young Men with Low Birth Weight
J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1530 - 1534.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. J. De Blasio, K. L. Gatford, I. C. McMillen, J. S. Robinson, and J. A. Owens
Placental Restriction of Fetal Growth Increases Insulin Action, Growth, and Adiposity in the Young Lamb
Endocrinology, March 1, 2007; 148(3): 1350 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
S. R. de Rooij, R. C. Painter, D. I.W. Phillips, C. Osmond, R. P.J. Michels, I. F. Godsland, P. M.M. Bossuyt, O. P. Bleker, and T. J. Roseboom
Impaired Insulin Secretion After Prenatal Exposure to the Dutch Famine
Diabetes Care, August 1, 2006; 29(8): 1897 - 1901.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. Poulsen and A. Vaag
The Intrauterine Environment as Reflected by Birth Size and Twin and Zygosity Status Influences Insulin Action and Intracellular Glucose Metabolism in an Age- or Time-Dependent Manner
Diabetes, June 1, 2006; 55(6): 1819 - 1825.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. W. Limesand, P. J. Rozance, G. O. Zerbe, J. C. Hutton, and W. W. Hay Jr.
Attenuated Insulin Release and Storage in Fetal Sheep Pancreatic Islets with Intrauterine Growth Restriction
Endocrinology, March 1, 2006; 147(3): 1488 - 1497.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. A. Simmons, I. Suponitsky-Kroyter, and M. A. Selak
Progressive Accumulation of Mitochondrial DNA Mutations and Decline in Mitochondrial Function Lead to {beta}-Cell Failure
J. Biol. Chem., August 5, 2005; 280(31): 28785 - 28791.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. H. Schou, K. Pilgaard, T. Vilsboll, C. B. Jensen, C. F. Deacon, J. J. Holst, A. Volund, S. Madsbad, and A. A. Vaag
Normal Secretion and Action of the Gut Incretin Hormones Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Polypeptide in Young Men with Low Birth Weight
J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4912 - 4919.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Verhaeghe, R. van Bree, E. van Herck, and W. Coopmans
Exogenous Corticosteroids and in Utero Oxygenation Modulate Indices of Fetal Insulin Secretion
J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3449 - 3453.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. C. Jimenez-Chillaron, M. Hernandez-Valencia, C. Reamer, S. Fisher, A. Joszi, M. Hirshman, A. Oge, S. Walrond, R. Przybyla, C. Boozer, et al.
{beta}-Cell Secretory Dysfunction in the Pathogenesis of Low Birth Weight-Associated Diabetes: A Murine Model
Diabetes, March 1, 2005; 54(3): 702 - 711.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
S. B Haugaard, O. Andersen, F. Dela, J. J. Holst, H. Storgaard, M. Fenger, J. Iversen, and S. Madsbad
Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic {beta}-cells
Eur. J. Endocrinol., January 1, 2005; 152(1): 103 - 112.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
R. Huxley, C. G. Owen, P. H. Whincup, D. G. Cook, S. Colman, and R. Collins
Birth Weight and Subsequent Cholesterol Levels: Exploration of the "Fetal Origins" Hypothesis
JAMA, December 8, 2004; 292(22): 2755 - 2764.
[Abstract] [Full Text] [PDF]

Home page
 NeoReviewsHome page
R. Simmons
Fetal Origins of Adult Disease: Concepts and Controversies
NeoReviews, December 1, 2004; 5(12): e511 - e515.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. B. Haugaard, O. Andersen, H. Storgaard, F. Dela, J. J. Holst, J. Iversen, J. O. Nielsen, and S. Madsbad
Insulin secretion in lipodystrophic HIV-infected patients is associated with high levels of nonglucose secretagogues and insulin resistance of {beta}-cells
Am J Physiol Endocrinol Metab, October 1, 2004; 287(4): E677 - E685.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. L. Gatford, M. J. De Blasio, P. Thavaneswaran, J. S. Robinson, I. C. McMillen, and J. A. Owens
Postnatal ontogeny of glucose homeostasis and insulin action in sheep
Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E1050 - E1059.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. B. Jensen, H. Storgaard, J. J. Holst, F. Dela, S. Madsbad, and A. A. Vaag
Insulin Secretion and Cellular Glucose Metabolism after Prolonged Low-Grade Intralipid Infusion in Young Men
J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2775 - 2783.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
T. S. Hermann, C. Rask-Madsen, N. Ihlemann, H. Dominguez, C. B. Jensen, H. Storgaard, A. A. Vaag, L. Kober, and C. Torp-Pedersen
Normal Insulin-Stimulated Endothelial Function and Impaired Insulin-Stimulated Muscle Glucose Uptake in Young Adults with Low Birth Weight
J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1252 - 1257.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. Freemark
Pharmacologic Approaches to the Prevention of Type 2 Diabetes in High Risk Pediatric Patients
J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 3 - 13.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. L. Kind, P. M. Clifton, P. A. Grant, P. C. Owens, A. Sohlstrom, C. T. Roberts, J. S. Robinson, and J. A. Owens
Effect of maternal feed restriction during pregnancy on glucose tolerance in the adult guinea pig
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R140 - R152.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2002 by the American Diabetes Association.