|
 |
|
|||||||
|
|||||||||
Diabetes 51:1699-1707, 2002
© 2002 by the American Diabetes Association, Inc.
Mature Adipocytes Inhibit In Vitro Differentiation of Human Preadipocytes via Angiotensin Type 1 Receptors
From the Max Delbrück Center for Molecular Medicine, HELIOS Klinikum-Berlin, Franz Volhard Clinic, Medical Faculty of the Charité, Humboldt University of Berlin, Berlin, Germany
Recent studies suggest that angiotensin II (Ang II) plays a role in the adipogenesis of murine preadipocytes. Here, we examined the role of Ang II for the differentiation of primary cultured human preadipocytes. Preadipocytes were isolated from human adipose tissue and stimulated to differentiate. Quantitation of gene expression during adipogenesis was performed for renin-angiotensin system (RAS) genes. The influence of the RAS on adipogenic differentiation was investigated by addition of either angiotensinogen (AGT), Ang II, or angiotensin receptor antagonists to the differentiation medium. We also examined the influence of adipocytes on adipogenesis by co-culture experiments. Expression of the RAS genes AGT, renin, angiotensin-converting enzyme, and Ang II type 1 receptor increased during adipogenesis. Stimulation of the Ang II type 1 receptor by Ang II reduced adipose conversion, whereas blockade of this receptor markedly enhanced adipogenesis. Adipocytes were able to inhibit preadipocyte differentiation in the co-culture, and this effect was abolished by blockade of the Ang II type 1 receptor. This finding points to a functional role of the RAS in the differentiation of human adipose tissue. Because AGT secretion and Ang II generation are characteristic features of adipogenesis, we postulate a paracrine negative-feedback loop that inhibits further recruitment of preadipocytes by maturing adipocytes.
CiteULike 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Zhang, D. C.Y. Yeung, M. Karpisek, D. Stejskal, Z.-G. Zhou, F. Liu, R. L.C. Wong, W.-S. Chow, A. W.K. Tso, K. S.L. Lam, et al. Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans Diabetes, May 1, 2008; 57(5): 1246 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. S. Santos, L. R. Fernandes, E. G. Mario, A. V. M. Ferreira, L. C. J. Porto, J. I. Alvarez-Leite, L. M. Botion, M. Bader, N. Alenina, and R. A. S. Santos Mas Deficiency in FVB/N Mice Produces Marked Changes in Lipid and Glycemic Metabolism Diabetes, February 1, 2008; 57(2): 340 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Wang, M. G. Larson, M. J. Keyes, D. Levy, E. J. Benjamin, and R. S. Vasan Association of Plasma Natriuretic Peptide Levels With Metabolic Risk Factors in Ambulatory Individuals Circulation, March 20, 2007; 115(11): 1345 - 1353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Achard, S. Boullu-Ciocca, R. Desbriere, G. Nguyen, and M. Grino Renin receptor expression in human adipose tissue Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R274 - R282. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Matsushita, Y. Wu, Y. Okamoto, R. E. Pratt, and V. J. Dzau Local Renin Angiotensin Expression Regulates Human Mesenchymal Stem Cell Differentiation to Adipocytes Hypertension, December 1, 2006; 48(6): 1095 - 1102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Esler, N. Straznicky, N. Eikelis, K. Masuo, G. Lambert, and E. Lambert Mechanisms of Sympathetic Activation in Obesity-Related Hypertension Hypertension, November 1, 2006; 48(5): 787 - 796. [Full Text] [PDF]
|
|
|
|
|
|
J. Janke, S. Engeli, M. Boschmann, F. Adams, J. Bohnke, F. C. Luft, A. M. Sharma, and J. Jordan Retinol-binding protein 4 in human obesity. Diabetes, October 1, 2006; 55(10): 2805 - 2810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tsuchiya, T. Yoshimoto, Y. Hirono, T. Tateno, T. Sugiyama, and Y. Hirata Angiotensin II induces monocyte chemoattractant protein-1 expression via a nuclear factor-{kappa}B-dependent pathway in rat preadipocytes Am J Physiol Endocrinol Metab, October 1, 2006; 291(4): E771 - E778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Sharma Telmisartan: The ACE of ARBs? Hypertension, May 1, 2006; 47(5): 822 - 823. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Patzak, J. Bontscho, E. Lai, E. Kupsch, A. Skalweit, C.-M. Richter, M. Zimmermann, C. Thone-Reineke, O. Joehren, M. Godes, et al. Angiotensin II sensitivity of afferent glomerular arterioles in endothelin-1 transgenic mice Nephrol. Dial. Transplant., December 1, 2005; 20(12): 2681 - 2689. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schupp, M. Clemenz, R. Gineste, H. Witt, J. Janke, S. Helleboid, N. Hennuyer, P. Ruiz, T. Unger, B. Staels, et al. Molecular Characterization of New Selective Peroxisome Proliferator-Activated Receptor {gamma} Modulators With Angiotensin Receptor Blocking Activity Diabetes, December 1, 2005; 54(12): 3442 - 3452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Engeli Is there a pathophysiological role for perivascular adipocytes? Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1794 - H1795. [Full Text] [PDF]
|
|
|
|
|
|
C. Barandier, J.-P. Montani, and Z. Yang Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: effects of aging and obesity Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1807 - H1813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Engeli, J. Bohnke, M. Feldpausch, K. Gorzelniak, J. Janke, S. Batkai, P. Pacher, J. Harvey-White, F. C. Luft, A. M. Sharma, et al. Activation of the Peripheral Endocannabinoid System in Human Obesity Diabetes, October 1, 2005; 54(10): 2838 - 2843. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Kouyama, T. Suganami, J. Nishida, M. Tanaka, T. Toyoda, M. Kiso, T. Chiwata, Y. Miyamoto, Y. Yoshimasa, A. Fukamizu, et al. Attenuation of Diet-Induced Weight Gain and Adiposity through Increased Energy Expenditure in Mice Lacking Angiotensin II Type 1a Receptor Endocrinology, August 1, 2005; 146(8): 3481 - 3489. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Koh, M. J. Quon, S. H. Han, J. Y. Ahn, D. K. Jin, H. S. Kim, D. S. Kim, and E. K. Shin Vascular and Metabolic Effects of Combined Therapy With Ramipril and Simvastatin in Patients With Type 2 Diabetes Hypertension, June 1, 2005; 45(6): 1088 - 1093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Juan, Y. Chien, L.-Y. Wu, W.-M. Yang, C.-L. Chang, Y.-H. Lai, P.-H. Ho, C. F. Kwok, and L.-T. Ho Angiotensin II Enhances Insulin Sensitivity in Vitro and in Vivo Endocrinology, May 1, 2005; 146(5): 2246 - 2254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Yvan-Charvet, P. Even, M. Bloch-Faure, M. Guerre-Millo, N. Moustaid-Moussa, P. Ferre, and A. Quignard-Boulange Deletion of the Angiotensin Type 2 Receptor (AT2R) Reduces Adipose Cell Size and Protects From Diet-Induced Obesity and Insulin Resistance Diabetes, April 1, 2005; 54(4): 991 - 999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Aoki, S. Toda, T. Ando, and H. Sugihara Bone Marrow Stromal Cells, Preadipocytes, and Dermal Fibroblasts Promote Epidermal Regeneration in Their Distinctive Fashions Mol. Biol. Cell, October 1, 2004; 15(10): 4647 - 4657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Engeli, J. Janke, K. Gorzelniak, J. Bohnke, N. Ghose, C. Lindschau, F. C. Luft, and A. M. Sharma Regulation of the nitric oxide system in human adipose tissue J. Lipid Res., September 1, 2004; 45(9): 1640 - 1648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Sharma Is There a Rationale for Angiotensin Blockade in the Management of Obesity Hypertension? Hypertension, July 1, 2004; 44(1): 12 - 19. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Rahmouni, A. L. Mark, W. G. Haynes, and C. D. Sigmund Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E891 - E895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schupp, J. Janke, R. Clasen, T. Unger, and U. Kintscher Angiotensin Type 1 Receptor Blockers Induce Peroxisome Proliferator-Activated Receptor-{gamma} Activity Circulation, May 4, 2004; 109(17): 2054 - 2057. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Benson, H. A. Pershadsingh, C. I. Ho, A. Chittiboyina, P. Desai, M. Pravenec, N. Qi, J. Wang, M. A. Avery, and T. W. Kurtz Identification of Telmisartan as a Unique Angiotensin II Receptor Antagonist With Selective PPAR{gamma}-Modulating Activity Hypertension, May 1, 2004; 43(5): 993 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shiuchi, M. Iwai, H.-S. Li, L. Wu, L.-J. Min, J.-M. Li, M. Okumura, T.-X. Cui, and M. Horiuchi Angiotensin II Type-1 Receptor Blocker Valsartan Enhances Insulin Sensitivity in Skeletal Muscles of Diabetic Mice Hypertension, May 1, 2004; 43(5): 1003 - 1010. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sekiya, J.-i. Osuga, H. Okazaki, N. Yahagi, K. Harada, W.-J. Shen, Y. Tamura, S. Tomita, Y. Iizuka, K. Ohashi, et al. Absence of Hormone-sensitive Lipase Inhibits Obesity and Adipogenesis in Lepob/ob Mice J. Biol. Chem., April 9, 2004; 279(15): 15084 - 15090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Serazin, M.-N. Dieudonne, M. Morot, P. de Mazancourt, and Y. Giudicelli cAMP-positive regulation of angiotensinogen gene expression and protein secretion in rat adipose tissue Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E434 - E438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Padwal and A. Laupacis Antihypertensive Therapy and Incidence of Type 2 Diabetes: A systematic review Diabetes Care, January 1, 2004; 27(1): 247 - 255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Sharma, J. Janke, K. Gorzelniak, S. Engeli, and F. C. Luft Angiotensin Blockade Prevents Type 2 Diabetes by Formation of Fat Cells Hypertension, November 1, 2002; 40(5): 609 - 611. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Diabetes | Diabetes Care | Clinical Diabetes | Diabetes Spectrum |