HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Walder, K. Articles by Collier, G. R. Search for Related Content PubMed PubMed Citation Articles by Walder, K. Articles by Collier, G. R. Social Bookmarking                What's this?

Tanis: A Link Between Type 2 Diabetes and Inflammation?

¹ Metabolic Research Unit, School of Health Sciences, Deakin University, Waurn Ponds, Victoria, Australia
² Lipha SA Research and Development, Lyon, France
³ International Diabetes Institute, Caulfield, Australia
⁴ Autogen, South Melbourne, Australia

Here we describe a novel protein, which we have named Tanis, that is implicated in type 2 diabetes and inflammation. In Psammomys obesus, a unique polygenic animal model of type 2 diabetes and the metabolic syndrome, Tanis is expressed in the liver in inverse proportion to circulating glucose (P = 0.010) and insulin levels (P = 0.004) and in direct proportion with plasma triglyceride concentrations (P = 0.007). Hepatic Tanis gene expression was markedly increased (3.1-fold) after a 24-h fast in diabetic but not in nondiabetic P. obesus. In addition, glucose inhibited Tanis gene expression in cultured hepatocytes (P = 0.006) as well as in several other cell types (P = 0.001–0.011). Thus, Tanis seems to be regulated by glucose and is dysregulated in the diabetic state. Yeast-2 hybrid screening identified serum amyloid A (SAA), an acute-phase inflammatory response protein, as an interacting protein of Tanis, and this was confirmed by Biacore experiments. SAA and other acute-phase proteins have been the focus of recent attention as risk factors for cardiovascular disease, and we contend that Tanis and its interaction with SAA may provide a mechanistic link among type 2 diabetes, inflammation, and cardiovascular disease.

CiteULike

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				Y. W. Asmann, C. S. Stump, K. R. Short, J. M. Coenen-Schimke, Z. Guo, M. L. Bigelow, and K. S. Nair Skeletal Muscle Mitochondrial Functions, Mitochondrial DNA Copy Numbers, and Gene Transcript Profiles in Type 2 Diabetic and Nondiabetic Subjects at Equal Levels of Low or High Insulin and Euglycemia Diabetes, December 1, 2006; 55(12): 3309 - 3319. [Abstract] [Full Text] [PDF]

				R. He, L. W. Shepard, J. Chen, Z. K. Pan, and R. D. Ye Serum Amyloid A Is an Endogenous Ligand That Differentially Induces IL-12 and IL-23 J. Immunol., September 15, 2006; 177(6): 4072 - 4079. [Abstract] [Full Text] [PDF]

				C. Shah, R. Hari-Dass, and J. G. Raynes Serum amyloid A is an innate immune opsonin for Gram-negative bacteria Blood, September 1, 2006; 108(5): 1751 - 1757. [Abstract] [Full Text] [PDF]

				S. Abe-Dohmae, K. H. Kato, Y. Kumon, W. Hu, H. Ishigami, N. Iwamoto, M. Okazaki, C.-A. Wu, M. Tsujita, K. Ueda, et al. Serum amyloid A generates high density lipoprotein with cellular lipid in an ABCA1- or ABCA7-dependent manner J. Lipid Res., July 1, 2006; 47(7): 1542 - 1550. [Abstract] [Full Text] [PDF]

				R. Hari-Dass, C. Shah, D. J. Meyer, and J. G. Raynes Serum Amyloid A Protein Binds to Outer Membrane Protein A of Gram-negative Bacteria J. Biol. Chem., May 13, 2005; 280(19): 18562 - 18567. [Abstract] [Full Text] [PDF]

				K. Sjoholm, J. Palming, L. E. Olofsson, A. Gummesson, P.-A. Svensson, T. C. Lystig, E. Jennische, J. Brandberg, J. S. Torgerson, B. Carlsson, et al. A Microarray Search for Genes Predominantly Expressed in Human Omental Adipocytes: Adipose Tissue as a Major Production Site of Serum Amyloid A J. Clin. Endocrinol. Metab., April 1, 2005; 90(4): 2233 - 2239. [Abstract] [Full Text] [PDF]

				H. K.R. Karlsson, H. Tsuchida, S. Lake, H. A. Koistinen, and A. Krook Relationship Between Serum Amyloid A Level and Tanis/SelS mRNA Expression in Skeletal Muscle and Adipose Tissue From Healthy and Type 2 Diabetic Subjects Diabetes, June 1, 2004; 53(6): 1424 - 1428. [Abstract] [Full Text] [PDF]

				A. Svatikova, R. Wolk, A. S. Shamsuzzaman, T. Kara, E. J. Olson, and V. K. Somers Serum Amyloid A in Obstructive Sleep Apnea Circulation, September 23, 2003; 108(12): 1451 - 1454. [Abstract] [Full Text] [PDF]

				Y. Gao, K. Walder, T. Sunderland, L. Kantham, H. C. Feng, M. Quick, N. Bishara, A. de Silva, G. Augert, J. Tenne-Brown, et al. Elevation in Tanis Expression Alters Glucose Metabolism and Insulin Sensitivity in H4IIE Cells Diabetes, April 1, 2003; 52(4): 929 - 934. [Abstract] [Full Text] [PDF]