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Diabetes 51:1986-1988, 2002
© 2002 by the American Diabetes Association, Inc.

Brief Genetics Report

Insertion/Deletion Polymorphism of the ACE Gene Is Associated With Type 2 Diabetes

Yan Feng1,2, Tianhua Niu3, Xin Xu3, Changzhong Chen3, Qiongfang Li1, Rongli Qian4, Guoying Wang1,2, and Xiping Xu2,3

1 Division of Endocrinology, the Third Affiliated Hospital of Beijing University, Beijing, China
2 Center for Ecogenetics and Reproductive Health, Beijing University, Beijing, China
3 Program for Popular Genetics, Harvard School of Public Health, Boston, Massachusetts
4 Division of Endocrinology, the First Affiliated Hospital of Beijing University, Beijing, China

In an attempt to examine the role of an ACE gene insertion/deletion (I/D) polymorphism in type 2 diabetes, we conducted a case-control association study among 132 couple-pairs from northern China. The genotype frequencies for II, ID, and DD were 39.8, 39.8, and 20.3%, respectively, in the case group and 44.8, 44.8, and 10.4% in the control group. The DD frequency was significantly higher in the case group than in the control group ({chi}21 = 4.77, P = 0.03), suggesting that the DD genotype is associated with an increased susceptibility to type 2 diabetes in our study population.


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Copyright © 2002 by the American Diabetes Association.