HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hofmann, S. M. Articles by Vlassara, H. Search for Related Content PubMed PubMed Citation Articles by Hofmann, S. M. Articles by Vlassara, H. Social Bookmarking                What's this?

Improved Insulin Sensitivity Is Associated With Restricted Intake of Dietary Glycoxidation Products in the db/db Mouse

¹ Division of Experimental Diabetes and Aging, Mount Sinai School of Medicine, New York, New York
² Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, New York
³ Department of Pathology, Mount Sinai School of Medicine, New York, New York
⁴ Laboratory of Lipoprotein Research, the Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York

Advanced glycation end products (AGEs), known promoters of diabetic complications, form abundantly in heated foods and are ingested in bioreactive forms. To test whether dietary AGEs play a role in the progression of insulin resistance, C57/BL/KsJ db/db mice were randomly placed for 20 weeks on a diet with either a low AGE content (LAD) or a 3.4-fold higher content of AGE (high AGE diet [HAD]), including N-carboxymethyllysine (CML) and methylglyoxal (MG). LAD-fed mice showed lower fasting plasma insulin levels throughout the study (P = 0.01). Body weight was reduced by 13% compared with HAD-fed mice (P = 0.04) despite equal food intake. LAD-fed mice exhibited significantly improved responses to both glucose (at 40 min, P = 0.003) and insulin (at 60 min, P = 0.007) tolerance tests, which correlated with a twofold higher glucose uptake by adipose tissue (P = 0.02). Compared with the severe hypertrophy and morphological disorganization of islets from HAD-fed mice, LAD-fed mice presented a better-preserved structure of the islets. LAD-fed mice demonstrated significantly increased plasma HDL concentrations (P < 0.0001). Consistent with these observations, LAD-fed mice exhibited twofold lower serum CML and MG concentrations compared with HAD-fed mice (P = 0.02). These results demonstrate that reduced AGE intake leads to lower levels of circulating AGE and to improved insulin sensitivity in db/db mice.

CiteULike

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				S. M. Hofmann, D. Perez-Tilve, T. M. Greer, B. A. Coburn, E. Grant, J. E. Basford, M. H. Tschop, and D. Y. Hui Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E Deficient Mice Diabetes, January 1, 2008; 57(1): 5 - 12. [Abstract] [Full Text] [PDF]

				R. Dhingra, L. Sullivan, P. F. Jacques, T. J. Wang, C. S. Fox, J. B. Meigs, R. B. D'Agostino, J. M. Gaziano, and R. S. Vasan Soft Drink Consumption and Risk of Developing Cardiometabolic Risk Factors and the Metabolic Syndrome in Middle-Aged Adults in the Community Circulation, July 31, 2007; 116(5): 480 - 488. [Abstract] [Full Text] [PDF]

				J. Montonen, R. Jarvinen, P. Knekt, M. Heliovaara, and A. Reunanen Consumption of Sweetened Beverages and Intakes of Fructose and Glucose Predict Type 2 Diabetes Occurrence J. Nutr., June 1, 2007; 137(6): 1447 - 1454. [Abstract] [Full Text] [PDF]

				W. Cai, J. C. He, L. Zhu, X. Chen, S. Wallenstein, G. E. Striker, and H. Vlassara Reduced Oxidant Stress and Extended Lifespan in Mice Exposed to a Low Glycotoxin Diet: Association with Increased AGER1 Expression Am. J. Pathol., June 1, 2007; 170(6): 1893 - 1902. [Abstract] [Full Text] [PDF]

				M. Negrean, A. Stirban, B. Stratmann, T. Gawlowski, T. Horstmann, C. Gotting, K. Kleesiek, M. Mueller-Roesel, T. Koschinsky, J. Uribarri, et al. Effects of low- and high-advanced glycation endproduct meals on macro- and microvascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus Am. J. Clinical Nutrition, May 1, 2007; 85(5): 1236 - 1243. [Abstract] [Full Text] [PDF]

				J. Uribarri, W. Cai, M. Peppa, S. Goodman, L. Ferrucci, G. Striker, and H. Vlassara Circulating Glycotoxins and Dietary Advanced Glycation Endproducts: Two Links to Inflammatory Response, Oxidative Stress, and Aging J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2007; 62(4): 427 - 433. [Abstract] [Full Text] [PDF]

				H. Koyama, T. Shoji, S. Fukumoto, K. Shinohara, T. Shoji, M. Emoto, K. Mori, H. Tahara, E. Ishimura, R. Kakiya, et al. Low Circulating Endogenous Secretory Receptor for AGEs Predicts Cardiovascular Mortality in Patients With End-Stage Renal Disease Arterioscler. Thromb. Vasc. Biol., January 1, 2007; 27(1): 147 - 153. [Abstract] [Full Text] [PDF]

				Y. Liu, C. Yan, Y. Wang, Y. Nakagawa, N. Nerio, A. Anghel, K. Lutfy, and T. C. Friedman Liver X Receptor Agonist T0901317 Inhibition of Glucocorticoid Receptor Expression in Hepatocytes May Contribute to the Amelioration of Diabetic Syndrome in db/db Mice Endocrinology, November 1, 2006; 147(11): 5061 - 5068. [Abstract] [Full Text] [PDF]

				J. Uribarri and K. R. Tuttle Advanced Glycation End Products and Nephrotoxicity of High-Protein Diets Clin. J. Am. Soc. Nephrol., November 1, 2006; 1(6): 1293 - 1299. [Abstract] [Full Text] [PDF]

				V. S Malik, M. B Schulze, and F. B Hu Intake of sugar-sweetened beverages and weight gain: a systematic review. Am. J. Clinical Nutrition, August 1, 2006; 84(2): 274 - 288. [Abstract] [Full Text] [PDF]

				A. G. Huebschmann, J. G. Regensteiner, H. Vlassara, and J. E.B. Reusch Diabetes and Advanced Glycoxidation End Products. Diabetes Care, June 1, 2006; 29(6): 1420 - 1432. [Full Text] [PDF]

				H. Liu, F. Zheng, Q. Cao, B. Ren, L. Zhu, G. Striker, and H. Vlassara Amelioration of oxidant stress by the defensin lysozyme Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E824 - E832. [Abstract] [Full Text] [PDF]

				A. G. Howarth, W. B. Wiehler, M. Pannirselvam, Y. Jiang, J. P. Berger, D. Severson, T. J. Anderson, and C. R. Triggle A Nonthiazolidinedione Peroxisome Proliferator-Activated Receptor {gamma} Agonist Reverses Endothelial Dysfunction in Diabetic (db/db-/-) Mice J. Pharmacol. Exp. Ther., January 1, 2006; 316(1): 364 - 370. [Abstract] [Full Text] [PDF]

				H. Koyama, T. Shoji, H. Yokoyama, K. Motoyama, K. Mori, S. Fukumoto, M. Emoto, T. Shoji, H. Tamei, H. Matsuki, et al. Plasma Level of Endogenous Secretory RAGE Is Associated With Components of the Metabolic Syndrome and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., December 1, 2005; 25(12): 2587 - 2593. [Abstract] [Full Text] [PDF]

				E. S. Schernhammer, F. B. Hu, E. Giovannucci, D. S. Michaud, G. A. Colditz, M. J. Stampfer, and C. S. Fuchs Sugar-Sweetened Soft Drink Consumption and Risk of Pancreatic Cancer in Two Prospective Cohorts Cancer Epidemiol. Biomarkers Prev., September 1, 2005; 14(9): 2098 - 2105. [Abstract] [Full Text] [PDF]

				O. Sandu, K. Song, W. Cai, F. Zheng, J. Uribarri, and H. Vlassara Insulin Resistance and Type 2 Diabetes in High-Fat-Fed Mice Are Linked to High Glycotoxin Intake Diabetes, August 1, 2005; 54(8): 2314 - 2319. [Abstract] [Full Text] [PDF]

				T. T. Fung, M. Schulze, J. E. Manson, W. C. Willett, and F. B. Hu Dietary Patterns, Meat Intake, and the Risk of Type 2 Diabetes in Women Arch Intern Med, November 8, 2004; 164(20): 2235 - 2240. [Abstract] [Full Text] [PDF]

				Y. Song, J. E. Manson, J. E. Buring, and S. Liu A Prospective Study of Red Meat Consumption and Type 2 Diabetes in Middle-Aged and Elderly Women: The Women's Health Study Diabetes Care, September 1, 2004; 27(9): 2108 - 2115. [Abstract] [Full Text] [PDF]

				M. B. Schulze, J. E. Manson, D. S. Ludwig, G. A. Colditz, M. J. Stampfer, W. C. Willett, and F. B. Hu Sugar-Sweetened Beverages, Weight Gain, and Incidence of Type 2 Diabetes in Young and Middle-Aged Women JAMA, August 25, 2004; 292(8): 927 - 934. [Abstract] [Full Text] [PDF]

				N. Zhang, A. Richter, J. Suriawinata, S. Harbaran, J. Altomonte, L. Cong, H. Zhang, K. Song, M. Meseck, J. Bromberg, et al. Elevated Vascular Endothelial Growth Factor Production in Islets Improves Islet Graft Vascularization Diabetes, April 1, 2004; 53(4): 963 - 970. [Abstract] [Full Text] [PDF]

				C. Miele, A. Riboulet, M. A. Maitan, F. Oriente, C. Romano, P. Formisano, J. Giudicelli, F. Beguinot, and E. Van Obberghen Human Glycated Albumin Affects Glucose Metabolism in L6 Skeletal Muscle Cells by Impairing Insulin-induced Insulin Receptor Substrate (IRS) Signaling through a Protein Kinase C{alpha}-mediated Mechanism J. Biol. Chem., November 28, 2003; 278(48): 47376 - 47387. [Abstract] [Full Text] [PDF]

				M. Peppa, H. Brem, P. Ehrlich, J.-G. Zhang, W. Cai, Z. Li, A. Croitoru, S. Thung, and H. Vlassara Adverse Effects of Dietary Glycotoxins on Wound Healing in Genetically Diabetic Mice Diabetes, November 1, 2003; 52(11): 2805 - 2813. [Abstract] [Full Text] [PDF]

				M. Peppa, C. He, M. Hattori, R. McEvoy, F. Zheng, and H. Vlassara Fetal or Neonatal Low-Glycotoxin Environment Prevents Autoimmune Diabetes in NOD Mice Diabetes, June 1, 2003; 52(6): 1441 - 1448. [Abstract] [Full Text] [PDF]