Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Eriksson, J. G.
Right arrow Articles by Barker, D. J.P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eriksson, J. G.
Right arrow Articles by Barker, D. J.P.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 51:2321-2324, 2002
© 2002 by the American Diabetes Association, Inc.

Brief Genetics Report

The Effects of the Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor-{gamma}2 Gene on Insulin Sensitivity and Insulin Metabolism Interact With Size at Birth

Johan G. Eriksson1, Virpi Lindi2, Matti Uusitupa2, Tom J. Forsén3, Markku Laakso4, Clive Osmond5, and David J.P. Barker5

1 Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Helsinki, Finland
2 Department of Clinical Nutrition, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
3 Department of Public Health, University of Helsinki, Helsinki, Finland
4 Department of Medicine, University of Kuopio, Kuopio, Finland
5 MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, U.K.

Type 2 diabetes is known to be associated with a small body size at birth. Body size at birth is an indicator of the intrauterine environment. There is also a well-established association between the peroxisome proliferator-activated receptor (PPAR)-{gamma}2 gene and type 2 diabetes. We therefore assessed whether the effects of the Pro12Ala polymorphism of the PPAR-{gamma}2 gene on insulin sensitivity and insulin concentrations in adult life are modified by size at birth. We found that the effects of the Pro12Pro and Pro12Ala polymorphisms of the PPAR-{gamma}2 gene in elderly people depended on their body size at birth. The well-known association between small body size at birth and insulin resistance was seen only in individuals with the high-risk Pro12Pro allele. In those who had low birth weight, the Pro12Pro polymorphism of the PPAR-{gamma}2 gene was associated with increased insulin resistance (P < 0.002) and elevated insulin concentrations (P < 0.003). These interactions between the effects of the Pro12Ala polymorphisms of the PPAR-{gamma}2 gene on adult traits and the effects of birth weight link two previously unknown associations together within the context of type 2 diabetes. We suggest that these findings reflect gene-environment interaction.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Physiol.Home page
B. S. Knight, C. E. Pennell, S. L. Adamson, and S. J. Lye
The impact of murine strain and sex on postnatal development after maternal dietary restriction during pregnancy
J. Physiol., June 1, 2007; 581(2): 873 - 881.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. Sedova, O. Seda, L. Kazdova, B. Chylikova, P. Hamet, J. Tremblay, V. Kren, and D. Krenova
Sucrose feeding during pregnancy and lactation elicits distinct metabolic response in offspring of an inbred genetic model of metabolic syndrome
Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1318 - E1324.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. G. Eriksson
Gene Polymorphisms, Size at Birth, and the Development of Hypertension and Type 2 Diabetes
J. Nutr., April 1, 2007; 137(4): 1063 - 1065.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. Meirhaeghe, C. A.G. Boreham, L. J. Murray, F. Richard, G. D. Smith, I. S. Young, and P. Amouyel
A Possible Role for the PPARG Pro12Ala Polymorphism in Preterm Birth
Diabetes, February 1, 2007; 56(2): 494 - 498.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
B. S. Knight, C. E. Pennell, R. Shah, and S. J. Lye
Strain Differences in the Impact of Dietary Restriction on Fetal Growth and Pregnancy in Mice
Reproductive Sciences, January 1, 2007; 14(1): 81 - 90.
[Abstract] [PDF]

Home page
 Eur J EndocrinolHome page
P D Gluckman and M A Hanson
Adult disease: echoes of the past
Eur. J. Endocrinol., November 1, 2006; 155(suppl_1): S47 - S50.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
S. R. de Rooij, R. C. Painter, D. I.W. Phillips, C. Osmond, M. W.T. Tanck, J. C. Defesche, P. M.M. Bossuyt, R. P.J. Michels, O. P. Bleker, and T. J. Roseboom
The Effects of the Pro12Ala Polymorphism of the Peroxisome Proliferator-Activated Receptor-{gamma}2 Gene on Glucose/Insulin Metabolism Interact With Prenatal Exposure to Famine
Diabetes Care, May 1, 2006; 29(5): 1052 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
D. J.P. Barker and S. P. Bagby
Developmental Antecedents of Cardiovascular Disease: A Historical Perspective
J. Am. Soc. Nephrol., September 1, 2005; 16(9): 2537 - 2544.
[Abstract] [Full Text] [PDF]

Home page
 BMJHome page
J. G Eriksson
The fetal origins hypothesis--10 years on
BMJ, May 14, 2005; 330(7500): 1096 - 1097.
[Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
D.J.P. Barker
The Developmental Origins of Adult Disease
J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 588S - 595S.
[Abstract] [Full Text] [PDF]

Home page
 J Intensive Care MedHome page
D. Brodsky and H. Christou
Current Concepts in Intrauterine Growth Restriction
J Intensive Care Med, November 1, 2004; 19(6): 307 - 319.
[Abstract] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
I. N. M. Day, X.-h. Chen, T. R. Gaunt, T. H. T. King, A. Voropanov, S. Ye, S. Rodriguez, H. E. Syddall, A. A. Sayer, E. M. Dennison, et al.
Late Life Metabolic Syndrome, Early Growth, and Common Polymorphism in the Growth Hormone and Placental Lactogen Gene Cluster
J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5569 - 5576.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. Kajantie, A. Rautanen, J. Kere, S. Andersson, H. Yliharsila, C. Osmond, D. J. P. Barker, T. Forsen, and J. Eriksson
The Effects of the ACE Gene Insertion/Deletion Polymorphism on Glucose Tolerance and Insulin Secretion in Elderly People Are Modified by Birth Weight
J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5738 - 5741.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
P. D. Gluckman and M. A. Hanson
Living with the Past: Evolution, Development, and Patterns of Disease
Science, September 17, 2004; 305(5691): 1733 - 1736.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Kubaszek, A. Markkanen, J. G. Eriksson, T. Forsen, C. Osmond, D. J. P. Barker, and M. Laakso
The Association of the K121Q Polymorphism of the Plasma Cell Glycoprotein-1 Gene with Type 2 Diabetes and Hypertension Depends on Size at Birth
J. Clin. Endocrinol. Metab., May 1, 2004; 89(5): 2044 - 2047.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
L. Lauren, M.-R. Jarvelin, P. Elliott, U. Sovio, A. Spellman, M. McCarthy, P. Emmett, I. Rogers, A.-L. Hartikainen, A. Pouta, et al.
Relationship between birthweight and blood lipid concentrations in later life: evidence from the existing literature
Int. J. Epidemiol., October 1, 2003; 32(5): 862 - 876.
[Abstract] [Full Text] [PDF]

Home page
 Int J EpidemiolHome page
D. Barker
Commentary: Developmental origins of raised serum cholesterol
Int. J. Epidemiol., October 1, 2003; 32(5): 876 - 877.
[Full Text] [PDF]

Home page
 J. Med. Genet.Home page
S Masud and S Ye
Effect of the peroxisome proliferator activated receptor-{gamma} gene Pro12Ala variant on body mass index: a meta-analysis
J. Med. Genet., October 1, 2003; 40(10): 773 - 780.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
J. G. Eriksson, C. Osmond, V. Lindi, M. Uusitupa, T. Forsen, M. Laakso, and D. Barker
Interactions Between Peroxisome Proliferator-Activated Receptor Gene Polymorphism and Birth Length Influence Risk for Type 2 Diabetes
Diabetes Care, August 1, 2003; 26(8): 2476 - 2477.
[Full Text] [PDF]

Home page
 Diabetes CareHome page
D. E. Laaksonen, H.-M. Lakka, J. Lynch, T. A. Lakka, L. Niskanen, R. Rauramaa, J. T. Salonen, and J. Kauhanen
Cardiorespiratory Fitness and Vigorous Leisure-Time Physical Activity Modify the Association of Small Size at Birth With the Metabolic Syndrome
Diabetes Care, July 1, 2003; 26(7): 2156 - 2164.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
W.H. L. Kao, J. Coresh, A. R. Shuldiner, E. Boerwinkle, M. S. Bray, and F. L. Brancati
Pro12Ala of the Peroxisome Proliferator-Activated Receptor-{gamma}2 Gene Is Associated With Lower Serum Insulin Levels in Nonobese African Americans: The Atherosclerosis Risk in Communities Study
Diabetes, June 1, 2003; 52(6): 1568 - 1572.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. Jaquet, D. A. Tregouet, T. Godefroy, V. Nicaud, D. Chevenne, L. Tiret, P. Czernichow, and C. Levy-Marchal
Combined Effects of Genetic and Environmental Factors on Insulin Resistance Associated With Reduced Fetal Growth
Diabetes, December 1, 2002; 51(12): 3473 - 3478.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2002 by the American Diabetes Association.