HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pørksen, N. Articles by Schmitz, O. Search for Related Content PubMed PubMed Citation Articles by Pørksen, N. Articles by Schmitz, O. Social Bookmarking                What's this?

Pulsatile Insulin Secretion: Detection, Regulation, and Role in Diabetes

¹ Department of Endocrinology and Metabolism M, Aarhus University Hospital, Aarhus, Denmark
² Department of Endocrinology and Diabetes, University of Southern California, Los Angeles, California
³ Department of Medicine and NSF Center for Biological Timing, Charlottesville, Virginia

Insulin concentrations oscillate at a periodicity of 5–15 min per oscillation. These oscillations are due to coordinate insulin secretory bursts, from millions of islets. The generation of common secretory bursts requires strong within-islet and within-pancreas coordination to synchronize the secretory activity from the ß-cell population. The overall contribution of this pulsatile mechanism dominates and accounts for the majority of insulin release. This review discusses the methods involved in the detection and quantification of periodicities and individual secretory bursts. The mechanism by which overall insulin secretion is regulated through changes in the pulsatile component is discussed for nerves, metabolites, hormones, and drugs. The impaired pulsatile secretion of insulin in type 2 diabetes has resulted in much focus on the impact of the insulin delivery pattern on insulin action, and improved action from oscillatory insulin exposure is demonstrated on liver, muscle, and adipose tissues. Therefore, not only is the dominant regulation of insulin through changes in secretory burst mass and amplitude, but the changes may affect insulin action. Finally, the role of impaired pulsatile release in early type 2 diabetes suggests a predictive value of studies on insulin pulsatility in the development of this disease.

CiteULike

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				D. J. Michael, W. Xiong, X. Geng, P. Drain, and R. H. Chow Human Insulin Vesicle Dynamics During Pulsatile Secretion Diabetes, May 1, 2007; 56(5): 1277 - 1288. [Abstract] [Full Text] [PDF]

				C. S. Nunemaker, D. H. Wasserman, O. P. McGuinness, I. R. Sweet, J. C. Teague, and L. S. Satin Insulin secretion in the conscious mouse is biphasic and pulsatile Am J Physiol Endocrinol Metab, March 1, 2006; 290(3): E523 - E529. [Abstract] [Full Text] [PDF]

				A. Caumo and L. Luzi First-phase insulin secretion: does it exist in real life? Considerations on shape and function Am J Physiol Endocrinol Metab, September 1, 2004; 287(3): E371 - E385. [Abstract] [Full Text] [PDF]

				F. Ashcroft and P. Rorsman Type 2 diabetes mellitus: not quite exciting enough? Hum. Mol. Genet., April 1, 2004; 13(suppl_1): R21 - R31. [Abstract] [Full Text] [PDF]