Diabetes
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Newgard, C. B.
Right arrow Articles by Sherry, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Newgard, C. B.
Right arrow Articles by Sherry, A. D.
Social Bookmarking
Add to CiteULike   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Diabetes 51:S389-S393, 2002
© 2002 by the American Diabetes Association, Inc.

Section 4: Beta-Cell Stimulus-Secretion Coupling: Metabolic Factors

Stimulus/Secretion Coupling Factors in Glucose-Stimulated Insulin Secretion

Insights Gained From a Multidisciplinary Approach

Christopher B. Newgard1, Danhong Lu1, Mette Valentin Jensen1, Jonathan Schissler1, Anne Boucher1, Shawn Burgess2, and A. Dean Sherry2

1 Sarah W. Stedman Center for Nutritional Studies, Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, North Carolina
2 Department of Radiology and Rogers NMR Center, University of Texas Southwestern Medical Center, Dallas, Texas

There is a growing appreciation for the complexity of the pathways involved in glucose-stimulated insulin secretion (GSIS) from pancreatic islet ß-cells. In our laboratory, this has stimulated the development of an interdisciplinary approach to the problem. In this study, we review recent studies combining the tools of recombinant adenovirus for gene delivery, the development of novel cell lines that exhibit either robust or weak GSIS, and nuclear magnetic resonance imaging for metabolic fingerprinting of glucose-stimulated cells. Using these tools, we demonstrate a potentially important role for pyruvate carboxylase-mediated pyruvate cycling pathways in the control of GSIS, and discuss potential coupling factors produced by such pathways.


Add to CiteULike CiteULike   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J Mol EndocrinolHome page
C. C Martin, B. P Flemming, Y. Wang, J. K Oeser, and R. M O'Brien
Foxa2 and MafA regulate islet-specific glucose-6-phosphatase catalytic subunit-related protein gene expression
J. Mol. Endocrinol., November 1, 2008; 41(5): 315 - 328.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Stiernet, M. Nenquin, P. Moulin, J.-C. Jonas, and J.-C. Henquin
Glucose-induced Cytosolic pH Changes in beta-Cells and Insulin Secretion Are Not Causally Related: STUDIES IN ISLETS LACKING THE NA+/H+ EXCHANGER NHE1
J. Biol. Chem., August 24, 2007; 282(34): 24538 - 24546.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
W. Wang, L. Upshaw, D M. Strong, R P. Robertson, and J. Reems
Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosensor system in non-human primate and human islets
J. Endocrinol., June 1, 2005; 185(3): 445 - 455.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Diabetes Diabetes Care Clinical Diabetes Diabetes Spectrum
Copyright © 2002 by the American Diabetes Association.